LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage

Brain Research, Journal Year: 2025, Volume and Issue: 1854, P. 149562 - 149562

Published: March 8, 2025

Language: Английский

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Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 18, 2025

Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical remain the most significant effective methods for relief of ischemia. Key elements these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, preserving ischemic penumbra. However, in therapeutic goals vascular secondary damage brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements understanding pathological processes associated with CIRI, interventions prevent its onset progression are still lacking. Recent research has indicated that mitophagy ferroptosis critical mechanisms development significantly contribute IS CIRI because common targets co-occurrence mechanisms. Therefore, exploring summarizing potential connections between during is crucial. In present review, we mainly focused on mitochondrial autophagy ferroptosis, their interaction, CIRI. We believe data show strong relationship interactive regulation. This information may underpin new approaches prevention treatment subsequent

Language: Английский

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Cerebroprotective action of butylphthalide in acute ischemic stroke: Potential role of Nrf2/HO-1 signaling pathway

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00461 - e00461

Published: Oct. 1, 2024

Language: Английский

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