The blood-brain barrier as a treatment target for neurodegenerative disorders DOI
Ruslan Rust, Abhay P. Sagare, Mingzi Zhang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Introduction The blood-brain barrier (BBB) is a vascular endothelial membrane which restricts entry of toxins, cells and microorganisms into the brain. At same time, BBB supplies brain with nutrients, key substrates for DNA RNA synthesis, regulatory molecules, removes metabolic waste products from to blood. breakdown and/or dysfunction have been shown in neurogenerative disorders including Alzheimer's disease (AD). Current data suggests that these changes may initiate contribute neuronal, synaptic cognitive dysfunction, possibly other aspects neurodegenerative processes.

Language: Английский

The blood-brain barrier as a treatment target for neurodegenerative disorders DOI
Ruslan Rust, Abhay P. Sagare, Mingzi Zhang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Introduction The blood-brain barrier (BBB) is a vascular endothelial membrane which restricts entry of toxins, cells and microorganisms into the brain. At same time, BBB supplies brain with nutrients, key substrates for DNA RNA synthesis, regulatory molecules, removes metabolic waste products from to blood. breakdown and/or dysfunction have been shown in neurogenerative disorders including Alzheimer's disease (AD). Current data suggests that these changes may initiate contribute neuronal, synaptic cognitive dysfunction, possibly other aspects neurodegenerative processes.

Language: Английский

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