Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter DOI

Mustafa Al Gburi,

Maria Antonietta Mazzola, Martina Absinta

et al.

Multiple Sclerosis Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Paramagnetic rim lesions (PRLs) are a magnetic resonance imaging (MRI) marker of compartmentalized intraparenchymal inflammation. The primary objective was to investigate clinical, demographic, and MRI factors that may be predictive the future formation PRL. This is retrospective analysis longitudinal data. Patients were included if they had ⩾1 gadolinium-enhancing lesion on any historical follow-up scan(s) ⩾6 months afterward standardized 3T using filtered phase component susceptibility-sensitive sequence ("SWAN"). Regression machine-learning models used identify ability immunological, treatment-related, predictors PRL formation. A total 64 patients having 229 contrast-enhancing (CELs) included. Among all predictors, diameter initial enhancing most influential for determining subsequent formation; every millimeter increase in increased risk by 44%. Other did not contribute additional information; administration steroids associated with effect. long-axis CEL best translational predictor at follow-up. measure holds promise as method high chronic active during acute inflammatory window.

Language: Английский

Mood Disorder and Multimorbidity Complicating a Multiple Sclerosis Diagnosis DOI
Jonathan D. Krett, Claire Riley, Scott S. Zamvil

et al.

Neurology Neuroimmunology & Neuroinflammation, Journal Year: 2025, Volume and Issue: 12(2)

Published: Feb. 11, 2025

A 28-year-old Black woman presented with both typical and atypical features of multiple sclerosis in the setting multimorbidity including psychiatric history, complicating diagnosis treatment. This case illustrates importance differential longitudinal follow-up before committing to disease-modifying therapy. Individualized treatment decision-making is highlighted.

Language: Английский

Citations

1
Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter DOI

Mustafa Al Gburi,

Maria Antonietta Mazzola, Martina Absinta

et al.

Multiple Sclerosis Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Paramagnetic rim lesions (PRLs) are a magnetic resonance imaging (MRI) marker of compartmentalized intraparenchymal inflammation. The primary objective was to investigate clinical, demographic, and MRI factors that may be predictive the future formation PRL. This is retrospective analysis longitudinal data. Patients were included if they had ⩾1 gadolinium-enhancing lesion on any historical follow-up scan(s) ⩾6 months afterward standardized 3T using filtered phase component susceptibility-sensitive sequence ("SWAN"). Regression machine-learning models used identify ability immunological, treatment-related, predictors PRL formation. A total 64 patients having 229 contrast-enhancing (CELs) included. Among all predictors, diameter initial enhancing most influential for determining subsequent formation; every millimeter increase in increased risk by 44%. Other did not contribute additional information; administration steroids associated with effect. long-axis CEL best translational predictor at follow-up. measure holds promise as method high chronic active during acute inflammatory window.

Language: Английский

Citations

0