Progress in brain research, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 104
Published: Jan. 1, 2024
Language: Английский
Science Advances, Journal Year: 2025, Volume and Issue: 11(2)
Published: Jan. 8, 2025
Repetitive transcranial magnetic stimulation (rTMS) is commonly used to study the brain or as a treatment for neurological disorders, but neural circuits and molecular mechanisms it affects remain unclear. To determine of rTMS regions they occur in, we spatial transcriptomics map changes gene expression across mouse in response two protocols. Our results revealed that alters genes related several cellular processes plasticity brain, which was both region– protocol–dependent. In cortex, effect dependent not only on cortical region also each layer. These findings uncover diverse induced by rTMS, will be useful interpreting its effects subcortical circuits.
Language: Английский
Citations
2
Journal of Psychiatric Research, Journal Year: 2022, Volume and Issue: 152, P. 384 - 396
Published: June 28, 2022
Accelerated transcranial magnetic stimulation (aTMS) is an emerging delivery schedule of repetitive TMS (rTMS). "accelerated" by applying two or more sessions within a day. This three-part review comprehensively reports the safety/tolerability, efficacy, and parameters affecting response across disorders.We used PubMed database to identify studies administering aTMS, which we defined as at least rTMS one day.Our targeted literature search identified 85 aTMS 18 diagnostic healthy control groups published from July 2001 June 2022. Excluding overlapping populations, 63 delivered 43,873 using low frequency, high theta burst in 1543 participants. Regarding safety, had similar seizure side effect incidence rates those reported for once daily rTMS. One was (0.0023% sessions, compared with 0.0075% rTMS). The most common effects were acute headache (28.4%), fatigue (8.6%), scalp discomfort (8.3%), all others under 5%. We evaluated efficacy 23 depression (the condition studies), finding average rate 42.4% remission 28.4% (range = 0-90.5% both). parameters, ranged 2 10 per day over 2-30 treatment days, 10-640 min between total 9-104 accelerated participant (including tapering sessions). Qualitatively, tends be higher increasing number day, pulses.The date suggests that safe well-tolerated conditions. Taken together, these early suggest potential effectiveness even highly refractory conditions added reduce patient burden while also expediting time. Future are warranted systematically investigate how key affect outcome durability.
Language: Английский
Citations
48
Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 10, 2024
Abstract Although neuroimaging has been widely applied in psychiatry, much of the exuberance decades past tempered by failed replications and a lack definitive evidence to support utility imaging inform clinical decisions. There are multiple promising ways forward demonstrate relevance for psychiatry at individual patient level. Ultra-high field magnetic resonance is developing as sensitive measure neurometabolic processes particular that holds promise new way characterize abnormalities well variability response treatment. Neuroimaging may also be particularly suited science brain stimulation interventions given can both targeting changes circuit communication function how effectively improve symptoms. We argue greater focus on data will pave stronger care psychiatry. stress importance using symptom-relevant experimental manipulations best demonstrated pairing with differential treatment prediction outcome measurement. The priorities shifting, which compels solidify patients over exploratory associations biomarkers ultimately fail replicate.
Language: Английский
Citations
11
Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 324, P. 660 - 669
Published: Jan. 2, 2023
Previous studies suggest that transcranial magnetic stimulation exerts antidepressant effects by altering functional connectivity (FC). However, knowledge about this mechanism is still limited. Here, we aimed to investigate the effect of bilateral sequential theta-burst (TBS) on FC in treatment-resistant depression (TRD) a sham-controlled longitudinal study. TRD patients (n = 20) underwent three-week treatment intermittent TBS left and continuous right dorsolateral prefrontal cortex (DLPFC). Upon trial's premature termination, 15 had received active five sham stimulation. Resting-state resonance imaging was performed at baseline after treatment. (left DLPFC) estimated for each participant, followed group statistics (t-tests). Furthermore, scores were analyzed (linear mixed models analysis) tested correlation with FC. Both groups exhibited reductions scores, however, there no significant main group, or time. Anticorrelations between DLPFC subgenual cingulate (sgACC) observed FC, corresponding changes severity. Treatment did not significantly change DLPFC-sgACC connectivity, but reduced target anterior insula. Our data compatible previous reports relevance anticorrelation sgACC success. insula highlight salience network. Due limited sample size, results should be interpreted caution are exploratory nature.
Language: Английский
Citations
20
Experimental Neurology, Journal Year: 2023, Volume and Issue: 373, P. 114660 - 114660
Published: Dec. 21, 2023
Language: Английский
Citations
15
Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 325, P. 713 - 720
Published: Jan. 20, 2023
Language: Английский
Citations
14
NeuroImage, Journal Year: 2024, Volume and Issue: 293, P. 120618 - 120618
Published: April 17, 2024
This systematic review investigated how prefrontal transcranial magnetic stimulation (TMS) immediately influences neuronal excitability based on oxygenation changes measured by functional resonance imaging (fMRI) or near-infrared spectroscopy (fNIRS). A thorough understanding of TMS-induced may enable clinicians to proactively adjust TMS parameters and optimize treatment plans. Five databases were searched for human studies evaluating brain using concurrent TMS/fMRI TMS/fNIRS. Thirty-seven (13 TMS/fNIRS studies, 24 studies) included in a qualitative synthesis. Despite methodological inconsistencies, distinct pattern activated nodes the frontoparietal central executive network, cingulo-opercular salience network default-mode emerged. Nodes cortex (especially dorsolateral cortex), insula cortex, striatal regions caudate, putamen), anterior cingulate thalamus. Meanwhile, high-frequency repetitive most consistently induced expected facilitatory effects these regions. However, varied (e.g., intensity, coil orientation, target sites) inter intra-individual variability state contribute observed heterogeneity co-activated Given considerable individual across limited evidence, conclusions should be drawn with caution.
Language: Английский
Citations
5
Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
This study aims to evaluate the intervention effect of intermittent Theta burst stimulation (iTBS) on bilateral dorsomedial prefrontal cortex (DMPFC) for negative symptoms in schizophrenia using functional near-infrared spectroscopy (fNIRS) confirm therapeutic significance DMPFC treating and provide new evidence treatment research. Thirty-nine patients with mild cognitive impairment were randomly divided into a group (n=20) control (n=19). The received iTBS DMPFC. sham treatment. Negative symptoms, function, emotional state, social function assessed at pre-treatment, post-treatment, 4-, 8-, 12-week follow-ups. Brain activation regions interest (ROIs) was evaluated through verbal fluency tasks. Changes scale scores analyzed by repeated measures ANOVA. After 20 sessions iTBS, Scale Assessment Symptoms (SANS) total sub-scale significantly improved group, statistically significant differences. SANS differed between pre- post-treatment both groups, markedly lower than pre-treatment better efficacy group. However, there no difference function. ROIs did not differ groups before intervention. treatment, higher controls, difference. Regarding connectivity, small-world properties Sigma Gamma enhanced. can effectively alleviate enhance schizophrenia.
Language: Английский
Citations
0
European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Transcranial direct current stimulation (tDCS) remains experimental for many psychiatric disorders in adults. Particularly childhood, there is limited research on the evidence efficacy and mechanisms of action tDCS developing brain. The objective this review to identify published studies examine children with or developmental early (prepubertal) childhood (aged under 10 years). Included Studies should meet following criteria: (1) (no reviews, no case reports), (2) international peer-reviewed journals, (3) written English, (4) conducted years age, (5) at enrolment a disorder.Eight were identified that fulfilled specified criteria. All investigated effect autism-spectrum-disorder (ASD). Anodal tDCS, mainly targeting left dorsolateral prefrontal cortex (dlPFC), showed positive effects reduction ASD symptoms. There has also been these stimulations are feasible, have good tolerability safe. was found be safe partially effective, but long-term changes connectivity during autism not proven. Other diseases investigated. This results lack knowledge regarding reactivity brain prepubertal period, which critical phase pathogenesis neurodevelopmental such as attention deficit hyperactivity disorder (ADHD), ASD, Tourette’s syndrome dyslexia.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 12, 2025
To investigate the hemodynamic differences in various brain regions between alcohol dependence (AlcD) patients and healthy controls during a verbal fluency task (VFT) using functional near-infrared spectroscopy (fNIRS), to further explore clinical predictive value of fNIRS before therapy for outcome relapse AlcD after 3 months. A retrospective survey was conducted on 123 149 same period. Baseline assessment performed analyze two groups different regions. During hospitalization, underwent 3-week benzodiazepine substitution therapy, gradually tapering off medication achieve withdrawal treatment goals. Three months discharge, we follow-up phone calls assess status patients. Compared control group, group had significantly lower integral values frontal bilateral temporal lobes, as well β-values all channels lobe except Ch13, lobes (p < 0.005), with no significant difference parietal channel(p > 0.05). ROC (Receiver Operating Characteristic Curve) analysis predicting within showed that area under curve highest (0.951, sensitivity 0.924, specificity 0.886). Patients exhibit impairments lobes. based VFT have good pharmacotherapy can be applied practice.
Language: Английский
Citations
0