Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories DOI Open Access
Kevin J. Clancy, Quentin Devignes, Boyu Ren

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 22, 2023

ABSTRACT Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates These findings provide novel mechanistic insights development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

Gender differences in the associations of psychosocial trauma and acute medical stressors with immune system activation and dementia risk DOI
Erin Logue, Robin C. Hilsabeck, Esther Melamed

et al.

The Clinical Neuropsychologist, Journal Year: 2024, Volume and Issue: 38(6), P. 1313 - 1333

Published: April 3, 2024

Objective: The purpose of this article is to provide a narrative review synthesizing the literature on differences between women and men in relationships among certain stressors associated with immune system activation their relationship cognitive dysfunction dementia. Method: We cycle stress leading neuroinflammation via cortisol neurochemical alterations, cell-mediated activation, pro-inflammatory cytokines, how implicated development follow by discussing sex physiology function. then work early life adversity (ELA) adverse childhood experiences (ACEs), post-traumatic disorder, acute medical stressors, associations Throughout, we emphasize women's presentations issues unique (e.g. trauma disorder prevalence). Conclusions: There need for more mechanistic longitudinal studies that consider accumulation, both physical emotional, as well greater focus traumas likely occur sexual abuse), decline

Language: Английский

Citations

2
Borderline Personality Disorder and Post-traumatic stress disorder in adolescents: Protocol for a comparative study of Borderline Personality Disorder with and without comorbid Post-traumatic Stress Disorder (BORDERSTRESS- ADO) DOI Creative Commons

M.T. Riou,

Harmony Duclos,

Méline Leribillard

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Background Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress (PTSD), with substantial prevalence of trauma history among affected individuals. The clinical, cognitive, cerebral parallels shared PTSD suggest trauma-related etiology for BPD. Studies consistently demonstrate reduction in hippocampal volume individuals BPD, echoing findings PTSD. However, the interpretation this neurobiological profile remains contentious, ongoing debates regarding independence these pathologies or potential exacerbation diminished BPD due to concurrent Differential impacts on subfields across both disorders may further complicate interpretation, suggesting as discriminant biomarker. This study aims characterize multidimensional specific profiles PTSD-related alterations, particular emphasis during adolescence, crucial period development. Methods focuses female adolescents, who are more population. Participants categorized into three groups: comorbid PTSD, control group matched healthy Data collection encompasses neuroimaging domains commonly disorders, utilizing various imaging markers (including gray matter macrostructure, white microstructural integrity, regional functional connectivity). Discussion examines adolescent without neuroimaging, cognitive levels. It first use comprehensive multi-modal approach within same sample. Additionally, it uniquely explores subfield differences adolescents. Analysis relationship between investigated effects comorbidity will elucidate alteration disorders. Trial registration: IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered 21/04/2021

Language: Английский

Citations

0
Borderline personality disorder and post-traumatic stress disorder in adolescents: protocol for a comparative study of borderline personality disorder with and without comorbid post-traumatic stress disorder (BORDERSTRESS-ADO) DOI Creative Commons

M.T. Riou,

Harmony Duclos,

Méline Leribillard

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 23, 2024

Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress (PTSD), with substantial prevalence of trauma history among affected individuals. The clinical, cognitive, cerebral parallels shared PTSD suggest trauma-related etiology for BPD. Studies consistently demonstrate reduction in hippocampal volume individuals BPD, echoing findings PTSD. However, the interpretation this neurobiological profile remains contentious, ongoing debates regarding independence these pathologies or potential exacerbation diminished BPD due to concurrent Differential impacts on subfields across both disorders may further complicate interpretation, suggesting as discriminant biomarker. This study aims characterize multidimensional specific profiles PTSD-related alterations, particular emphasis during adolescence, crucial period development. focuses female adolescents, who are more population. Participants categorized into three groups: comorbid PTSD, control group matched healthy Data collection encompasses neuroimaging domains commonly disorders, utilizing various imaging markers (including gray matter macrostructure, white microstructural integrity, regional functional connectivity). examines adolescent without neuroimaging, cognitive levels. It first use comprehensive multi-modal approach within same sample. Additionally, it uniquely explores subfield differences adolescents. Analysis relationship between investigated effects comorbidity will elucidate alteration disorders. IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered 21/04/2021.

Language: Английский

Citations

0
Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior DOI
Antonio Florido, Vincent R. Curtis, Nicolas C. Pégard

et al.

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories DOI Open Access
Kevin J. Clancy, Quentin Devignes, Boyu Ren

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 22, 2023

ABSTRACT Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates These findings provide novel mechanistic insights development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

Citations

1