Cited by The impact of mGlu2 or mGlu5 receptor activators on the production of L-arginine derivatives and the expression of PMRT5 or DDAH1 enzymes in animal models of cognitive decline.

The multifaceted role of mitochondria in autism spectrum disorder DOI

Igor Khaliulin,

Wajeha Hamoudi,

Haitham Amal

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Normal brain functioning relies on high aerobic energy production provided by mitochondria. Failure to supply a sufficient amount of energy, seen in different disorders, including autism spectrum disorder (ASD), may have significant negative impact development and support functions. Mitochondrial dysfunction, manifested the abnormal activities electron transport chain impaired metabolism, greatly contributes ASD. The aberrant this organelle is such importance that ASD has been proposed as mitochondrial disease. It should be noted not only function In particular, these organelles are involved regulation Ca 2+ homeostasis, mechanisms programmed cell death, autophagy, reactive oxygen nitrogen species (ROS RNS) production. Several syndromes originated from mitochondria-related mutations display phenotype. Abnormalities handling ATP mitochondria affect synaptic transmission, plasticity, development, contributing ROS regulate activity permeability transition pore (mPTP). prolonged opening affects redox state mitochondria, impairs oxidative phosphorylation, activates apoptosis, ultimately leading death. A dysregulation between enhanced processes apoptosis inhibited autophagy leads accumulation toxic products brains individuals with Although many still investigated, whether they cause or consequence unknown, accumulating data show breakdown any functions contribute review, we discuss multifaceted role various aspects neuroscience.

Language: Английский

Citations

Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models DOI

Huda Suloh,

Shashank Kumar Ojha,

Maryam Kartawy

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 26, 2025

Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by early molecular events that influence progression. Still, mechanisms caused different mutations of AD are not understood. We have performed a multidisciplinary study to investigate and compare stages pathology in two transgenic mouse models: P301S 5xFAD. Using SNOTRAP-based mass spectrometry, we assessed changes S-nitrosylation, nitric oxide-mediated post-translational modification, proteins both models during their juvenile age. The increased levels 3-nitrotyrosine confirmed nitrosative stress mutant mice. Systems biology analysis revealed shared processes between models, particularly γ-aminobutyric acid (GABA)ergic glutamatergic neurotransmission processes. In model, identified 273 S-nitrosylated (SNOed) cortex, with 244 uniquely SNOed diseased 5xFAD 309 were identified. found altered expression glutamate/GABA-related markers cortex hippocampus models. Additionally, phosphorylation mTOR signaling components hyperactivation this pathway Conversely, mice showed no significant except for elevated ribosomal protein S6 cortex. Our findings key stages. These could serve as potential biomarkers therapeutic targets early-stage AD.

Language: Английский

Citations

The nitration of SIRT6 aggravates neuronal damage during cerebral ischemia-reperfusion in rat DOI

Bingnan Guo, Bin Ma, Min Li

et al.

Nitric Oxide, Journal Year: 2024, Volume and Issue: 153, P. 26 - 40

Published: Oct. 5, 2024

Language: Английский

Citations

The Role of Thioredoxin System in Shank3 Mouse Model of Autism DOI

Wisam Bazbaz,

Maryam Kartawy,

Wajeha Hamoudi

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(4)

Published: Sept. 30, 2024

Language: Английский

Citations

Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis DOI

Manjeet Kumar,

Sidharth Mehan, Aakash Kumar

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1846, P. 149251 - 149251

Published: Oct. 9, 2024

Language: Английский

Citations

A Novel Thioredoxin-Mediated Mechanism in Autism Spectrum Disorder DOI

Haitham Amal,

Wisam Bazbaz,

Maryam Kartawy

et al.

Published: Jan. 1, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental characterized by difficulties in social interaction and communication, repetitive behaviors, restricted interests. Over time, the prevalence of ASD increasing, reaching 2% population to date. Unfortunately, underlying molecular mechanism behind remains unknown. Therefore, there no FDA-approved drug for treatment, It has been reported that oxidative nitrosative stress are strongly linked ASD. We have recently found nitric oxide (NO•) NO•-meditated post-transitional modifications play key role One proteins affected affecting NO• thioredoxin (Trx). Here we show Trx antioxidant system may crucial pathology. hypothesize altered Shank3 KO mouse model autism, which lead decreased activity nuclear factor erythroid 2-related 2 (Nrf2), leading stress, thus, contributing ASD-related phenotypes. To test this hypothesis, conducted vivo behavioral studies used primary cortical neurons derived from mutant mice as well human SH-SY5Y with SHANK3 mutation. showed significant changes levels redox mice. A Trx1 inhibitor PX-12 Nrf2 expression wild-type mice, causing abnormal alterations synaptic neurotransmission markers, an elevation stress. The tests revealed inhibition results ASD-like phenotype, similar observed autism. Our findings confirm strong link between ASD, including increased oxidative/nitrosative impaired phenotype. study pave way developing new treatments.

Language: Английский

Citations

Inhibition of Nitric Oxide Synthesis Prevents the Effects of Intermittent Social Defeat on Cocaine-Induced Conditioned Place Preference in Male Mice DOI

M. Ángeles Martínez-Caballero,

María Pilar García-Pardo, Claudia Calpe-López

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1203 - 1203

Published: Sept. 12, 2024

We have previously observed that

Language: Английский

Citations

Childhood anesthesia and autism risk: population and murine study DOI

Mingyang Sun,

Ningning Fu,

Ting Li

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(5)

Published: Jan. 1, 2024

Abstract Early childhood exposure to general anaesthesia has been linked potential changes in infant brain morphology and behaviour preclinical studies, contributing long-term behaviours associated with autism spectrum disorder. This study investigates the association between early risk of autism, using a population-based cohort matching for baseline characteristics evaluates effect sevoflurane on autism-like mice, Taiwan Maternal Child Health Database. Children aged 0–3 who received at least one 2004 2014 were matched 1:1 children not exposed. Risk ratios confidence intervals used assess relationship occurrence autism. Additionally, mice exposed 2 h postnatal days 5–7, related evaluated. Propensity score resulted 7530 each group. The incidence rates (IRs) 11.26 6.05 per 100 000 person-years unexposed groups, respectively. ratio following was 1.86 (95% interval, 1.34–2.59). In induced led downregulation high-risk genes, including ARID1B, GABRA5, GABRB3, GRIN2B, SHANK3 SUV420H1. is an increased Repeated induces behaviours, suggesting link development

Language: Английский

Citations

Role of Nitric oxide synthase II in the cognitive impairment due to experimental cerebral malaria DOI

Tathiany Igreja da Silva,

Tamires da Cunha Fernandes,

Emílio Telles de Sá Moreira

et al.

Nitric Oxide, Journal Year: 2024, Volume and Issue: 153, P. 41 - 49

Published: Oct. 9, 2024

Language: Английский

Citations

KLF4’s Role in Regulating Nitric Oxide Production and Promoting Microvascular Formation Following Ischemic Stroke DOI

Kuo Li, Chunyan Zhang,

Ling-yun Wang

et al.

Nitric Oxide, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations