Brazilian Journal of Medical and Biological Research,
Journal Year:
2024,
Volume and Issue:
57
Published: Jan. 1, 2024
Research
suggests
that
physical
exercise
is
associated
with
prevention
and
management
of
chronic
diseases.
The
influence
on
brain
function
metabolism
the
mechanisms
involved
are
well
documented
in
literature.
This
review
provides
a
comprehensive
overview
potential
implications
molecular
benefits
Parkinson's
disease,
Alzheimer's
epilepsy.
Here,
we
present
an
effects
various
aspects
function.
To
this
end,
conducted
extensive
literature
search
PubMed,
Web
Science,
Google
Scholar
databases
to
identify
articles
published
past
two
decades.
delves
into
key
including
modulation
neuroinflammation,
neurotrophic
factors,
synaptic
plasticity.
Moreover,
explored
role
advancing
therapeutic
strategies
for
these
In
conclusion,
highlights
importance
regular
as
complementary
non-pharmacological
treatment
individuals
neurological
disorders
such
Alzheimer's,
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 26, 2024
Abstract
Type
2
diabetes
(T2D)
can
cause
severe
cardiac
complications
at
functional,
histologic
and
molecular
levels.
These
pathological
could
be
mediated
by
ATP-releasing
channels
such
as
Panx1
ATP
receptors,
in
particular
P2X7.
The
aim
of
our
study
was
to
investigate
the
effect
high-intensity
interval
training
(HIIT)
on
T2D-induced
histopathological
levels,
with
a
focus
channels.
48
male
Wistar
rats
age
8
weeks
were
randomly
allocated
into
four
groups:
control
(Con),
Diabetes
(T2D),
Training
(TR),
+
(T2D
TR).
T2D
induced
high-fat
diet
plus
low
dose
(35
mg/kg)
STZ
administration.
Rats
TR
groups
underwent
an
8-weeks
program
involving
intervals
ranging
from
80
100%
their
maximum
running
speed
(Vmax),
4–10
per
session.
Protein
expression
Interleukin
1β
(IL1β),
10
(IL-10),
Pannexin
1
(Panx1),
P2X7R
(purinergic
P2X
receptor
7),
NLRP1
(NLR
Family
Pyrin
Domain
Containing
1),
BAX,
Bcl2
measured
heart
tissue.
Additionally,
we
assessed
function,
changes,
well
insulin
resistance
using
homeostasis
model
assessment
(HOMA-IR).
In
contrast
group,
HIIT
led
increased
protein
IL-10
heart.
It
also
resulted
improvements
systolic
diastolic
blood
pressures,
rate,
±
dp/dt
(maximum
minimum
changes
left
ventricular
pressure),
while
reducing
IL-1β,
Panx1,
P2X7R,
NLRP1,
BAX
levels
Furthermore,
pressure
(LVDP)
reduced
(
P
≤
0.05).
Moreover,
lesion
scores
but
decreased
HIIT,
along
reduction
fibrosis
percentage
results
this
suggest
that
cardioprotective
effects
diabetic
may
modulation
This
lead
inflammation
apoptosis,
improve
attenuate
injury
fibrosis.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Introduction:
High‐intensity
interval
training
(HIIT)
is
a
form
of
exercise
that
enhances
capacity
and
benefits
well‐being.
Resveratrol
naturally
occurring
polyphenol
prevalent
in
grapes
red
wine,
demonstrating
significant
health
effects
on
the
body.
This
study
sought
to
evaluate
synergistic
swimming
HIIT
resveratrol
intake
expression
SIRTs
4,
5,
superoxide
dismutases
(SOD1
SOD2)
frontal
lobe
elderly
rats.
Materials
Methods:
Forty‐five
male
Wistar
rats,
aged
22
months,
were
categorized
into
five
groups:
control
group
(CTL),
(Ex:
Exercise),
with
(R
+
Ex),
(R),
solvent
(vehicle).
The
R
Ex
engaged
high‐intensity
ingested
(10
mg/kg/day
via
gavage)
for
6
weeks.
During
initial
final
sessions
each
week,
blood
samples
from
rats
groups
collected
lactate
analysis.
proteins
4
as
well
SODs
1
2,
quantified
using
western
blot
approach.
Results:
Integrating
markedly
enhanced
SIRT4,
SIRT5,
antioxidant
enzymes
Conclusion:
HIIT,
particularly
their
effects,
provide
antiaging
Brain and Behavior,
Journal Year:
2025,
Volume and Issue:
15(3)
Published: March 1, 2025
ABSTRACT
Objective
Evidence
suggests
that
exercise
timing
is
crucial
in
reducing
the
impact
of
traumatic
brain
injury
(TBI).
The
present
study
explores
effects
delayed
and
early
on
damage,
cognitive
dysfunction,
anxiety
behavior
using
an
experimental
TBI
model.
Methods
We
randomly
assigned
36
male
rats
to
six
groups:
control
(sham,
TBI),
treadmill
(24hA,
1‐month
24
h
after
1WA
(1‐month
1
week
1MB
before
1MBA
TBI).
Results
caused
significant
impairments
behaviors,
as
well
increased
edema
(
p
<
0.05).
groups
showed
improvement
following
order
for
impairments:
>
24hA
1MB.
Compared
group,
starting
(24hA)
significantly
improved
all
variables
except
behavior.
Exercise
was
more
effective
than
other
0.05)
problems,
anxious
behavior,
damage.
Conclusion
Regular
or
a
consistent
routine
TBI,
such
athletes,
may
provide
most
benefits
from
intervention
TBI.
Starting
soon
(within
h)
help
protect
against
improve
learning
memory
by
cell
death
specific
regions
(CA1
CA3)
also
decreasing
TNF‐α
MDA
compared
later
(1
after).
npj Parkinson s Disease,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 23, 2025
Microglia
are
more
susceptible
to
ferroptosis
compared
neurons
and
astrocytes,
which
may
compromise
their
phagocytic
clearance
capabilities
of
α-synuclein
(α-syn)
in
Parkinson's
disease
(PD).
While
the
beneficial
effects
physical
exercise
(PE)
on
reducing
α-syn
deposition
PD
have
been
highlighted,
role
PE
modulating
microglial
remains
unclear.
This
study
focuses
impact
inhibiting
mitigating
accumulation.
We
demonstrate
that
voluntary
effectively
inhibits
ferroptosis.
Mechanistically,
PE-induced
upregulation
SLC7A11
by
suppressing
ALOX12,
thereby
enhancing
phagocytosis
α-syn,
is
paralleled
improvements
neurological
function
mice.
Collectively,
these
findings
not
only
underscore
critical
pathological
progression
but
also
elucidate
molecular
mechanism
attenuates
via
SLC7A11/ALOX12
axis.
Metabolic Brain Disease,
Journal Year:
2025,
Volume and Issue:
40(4)
Published: April 10, 2025
Abstract
The
neurodegenerative
condition
known
as
Parkinson’s
disease
(PD)
is
a
long-term
that
causes
both
motor
and
non-motor
symptoms.
It
curcumin
has
strong
neuroprotective
potential.
This
experimental
study
was
designed
to
examine
the
anti-inflammatory,
anti-apoptotic
effects
of
administered
alone
in
combination
with
L-DOPA
hippocampus
well
behavioral
symptoms
rotenone-induced
PD
model.
Forty-two
4-month-old
adult
male
Wistar
rats
were
randomly
divided
into
six
groups
follows:
Control,
Curcumin,
Rotenone,
Rotenone
plus
curcumin,
L-DOPA.
Control
group
received
vehicles,
(200
mg
kg
−1
,
daily
for
35
days),
rotenone
(2
test
or
(10
last
15
days)
their
addition
rotenone.
Pole,
sucrose
preference,
open
field,
elevated
maze,
Morris
water
maze
tests
performed
after
treatment.
Molecular
biochemical
analyses
tissue
serum
samples.
injection
caused
impairments
activity,
depressive-like
behavior,
learning
memory
functions.
also
increased
expressions
α-synuclein,
caspase
3,
NF-κB,
decreased
parkin
BDNF
hippocampus.
However,
especially
combined
treatment
normalized
all
these
impaired
molecular
variables.
In
conclusion,
may
exert
beneficial
strategies
PD-related
hippocampal
effects,
when
added
therapy.
