Angiotensin-(1-7) protective effects in neurocognitive disorders: molecular mechanisms to therapeutic implications DOI Creative Commons

Lillia Lucas,

Katherine Kimbark,

Victoria Vernail

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Cognition broadly refers to the ability perform mental processes such as learning and memory, attention, emotional awareness, higher-order thinking. Cognitive deficits can result from normal aging process or other factors disease progression injury. While exact etiology is not fully understood, emerging evidence suggests that enhanced inflammatory oxidative stress during dramatically decrease cognitive function in older adults, well contribute onset of neurocognitive disorders. Current treatments for disorders have limited efficacy typically focus on symptom attenuation rather than targeting intrinsic pathophysiology. With rising population, there a critical need identify novel treatment approaches target underlying mechanisms contributing In this regard, renin-angiotensin system (RAS) may provide an ideal target, hormonal has been implicated regulation responses impact functions. most research date focused deleterious role angiotensin (Ang) II pathways age-related decline disorders, more recent examined potential Ang-(1-7), protective hormone RAS, counteract these effects. This review highlights showing activation Ang-(1-7) reduces inflammation improve elicit neuroprotection, context both

Language: Английский

Angiotensin-(1-7) protective effects in neurocognitive disorders: molecular mechanisms to therapeutic implications DOI Creative Commons

Lillia Lucas,

Katherine Kimbark,

Victoria Vernail

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Cognition broadly refers to the ability perform mental processes such as learning and memory, attention, emotional awareness, higher-order thinking. Cognitive deficits can result from normal aging process or other factors disease progression injury. While exact etiology is not fully understood, emerging evidence suggests that enhanced inflammatory oxidative stress during dramatically decrease cognitive function in older adults, well contribute onset of neurocognitive disorders. Current treatments for disorders have limited efficacy typically focus on symptom attenuation rather than targeting intrinsic pathophysiology. With rising population, there a critical need identify novel treatment approaches target underlying mechanisms contributing In this regard, renin-angiotensin system (RAS) may provide an ideal target, hormonal has been implicated regulation responses impact functions. most research date focused deleterious role angiotensin (Ang) II pathways age-related decline disorders, more recent examined potential Ang-(1-7), protective hormone RAS, counteract these effects. This review highlights showing activation Ang-(1-7) reduces inflammation improve elicit neuroprotection, context both

Language: Английский

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