Systematic Review and Meta-Analysis: The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

To examine the association between newer generation antidepressants and insomnia as an adverse event (AE) in treatment of children adolescents with major depressive disorder (MDD). A systematic search was performed databases (inception to August 31st, 2023) retrieve double-blind, placebo-controlled, randomized controlled trials (RCTs) evaluating safety 19 acute (initial 6 12 weeks) aged ≤ 18 years MDD (primary analyses). RCTs anxiety disorders obsessive-compulsive (OCD) were retrieved from a recent meta-analysis included complementary analyses. mixed-effects logistic regression model used compare frequency antidepressant relative placebo group. Risk bias evaluated using Cochrane Bias 2 tool. In total, 20 (N = 5,357) 8 OCD 1,271) selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine (SNRIs) included. MDD, associated modest increase odds compared (OR 1.65, 95% CI 1.21-2.27, p 0.002), no significant difference SSRIs SNRIs. The showed low risk minor concerns for assessment insomnia. treatment-emergent significantly lower 1.62; 1.21-2.15) 2.89; 1.83-4.57) (p 0.03). Among individual evidence ≥ 3 studies, sertraline had highest OR (3.45; 1.91-6.24), while duloxetine lowest (1.38; 0.79 - 2.43). Children are at modestly increased experiencing during first weeks Antidepressant- disorder-specific variability may be relevant consider clinical decision-making.

Language: Английский

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Early experience with the new DORA daridorexant in patients with insomnia disorder and comorbid mental disturbances: Results of a naturalistic study with 3 months follow‐up

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Summary Insomnia disorder may affect mental health, increasing suicidal risk. Targeting insomnia is crucial in the clinical practice. Sixty‐six consecutive patients with according DSM‐5‐TR criteria were treated dual orexin receptor antagonist, daridorexant 50 mg. Baseline (T0), 1 month (T1) and 3 (T2) evaluations performed. severity (Insomnia Severity Index), mood, anxiety symptoms risk (Beck Depression Inventory‐II, Young Mania Rating Scale, Self‐Reported Anxiety Suicidal Ideation Scale), dysfunctional insomnia‐cognitive factors pre‐sleep arousal (Dysfunctional Beliefs About Sleep, Pre‐Sleep Arousal Scale) evaluated. The final sample included 66 ( n = 36, 54% females, mean age 60 ± 13.6 years). Most of them, 64%, suffered from comorbid unipolar/bipolar depression, disorders substance use disorders. Repeated ANOVA analyses showed that Index, Dysfunctional Sleep Scale total score decreased across time F 68.818, p < 0.001; 47.561, 28.142, 0.001, respectively). Similarly, Beck significantly over 0.001). Predictors remission Index 8) at T1 improvement 60.205, 0.001), 4.432, 0.041). T2 was best predicted by 3.993, 0.023). Multiple‐regression models Inventory‐II T2, manic somatic T2. With caution a naturalistic design, early experience targeting it be possible to improve not only but also symptoms.

Language: Английский

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Cognitive-Behavioral Therapists’ Experience on Relevance of Sleep and Sleep Disorders in Training and Clinical Practice: A Survey Study from Italy

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 48 - 48

Published: Jan. 7, 2025

Based on previous data reporting the status of health professionals' training about sleep clinical psychophysiology, insomnia, and its treatment in US Canada, this paper aims at providing a snapshot Italian situation, considering professionals qualified to offer cognitive behavioral therapy (CBT). Adding information different countries is important, as national systems differ significantly, distinct evidence-based pathways for change may be proposed. Two hundred thirteen CBT (180 females; 33 males) answered 5 min survey their experience recognizing treating disorders practice. The questionnaire was diffused through mailing list Behavioral Cognitive Therapy Society (Società Italiana di Terapia Comportamentale e Cognitiva, SITCC) throughout December 2023 January 2024. A total 213 participants completed survey. Only minor proportion respondents (37.1%) reported having received diagnosis insomnia or other disorders. Familiarity with psychological therapeutics mainly associated knowledge hygiene rules, relaxation, mindfulness techniques, but not core strategies (i.e., restriction stimulus control) regulation. less familiar were those pediatric insomnia. results study highlight scarce consideration problems practice Italy. As prevalent, an independent mental disorder, predictor somatic comorbid conditions, these findings underscore urgency enlarge strengthen psychology, problems, treatment.

Language: Английский

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Agarwood as a neuroprotective agent: a comprehensive review of existing evidence and potential avenues for future research

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

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The Power of Lifestyle Psychiatry: A New Approach to Mental Health

American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

The field of psychiatry has evolved over the past 2500 years. Between dynamic psychotherapy and psychopharmacology, lifestyle holds a different space. This approach capitalizes on medicine movement, as it promotes change within 6 domains activity. Apart from incorporating these pillars adjunctive therapy for either psychodynamic or psychotropic medication regimens, is frontier similar to other growing fields precision psychiatry, advanced learning in psychedelics digital mental health, psychiatric genetics. Any disruption into historical practice particularly with prescription medications, can be met scrutiny. We encourage keep an open mind our continues evolve. What makes powerful unique its ability assess evaluate internal external factors that contribute individual behaviors, may impact incorporate healthy actions. Internal include: emotional regulation, internalized trauma, cognitive factors, personality traits. On hand, include environmental barriers work-related burnout.

Language: Английский

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Sleep Disturbances in Generalized Anxiety Disorder: The Central Role of Insomnia

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106545 - 106545

Published: April 1, 2025

Language: Английский

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Anxiety in times of crisis – Epidemiology, neurobiology and treatment

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104076 - 104076

Published: Jan. 1, 2024

Language: Английский

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ADHD Detection Based on Human Action Recognition

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104093 - 104093

Published: Jan. 1, 2024

Language: Английский

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Sleep Quality Mediates the Relationship Between Sleep Hygiene and Psychological Stress Among Adults With Multiple Cardiovascular Risk Factors

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Poor sleep quality and psychological stress are interrelated disproportionately affect adults with multiple cardiovascular disease (CVD) risk factors. Maintaining an optimal home environment engaging in healthy bedtime behaviors important components of hygiene practices that influence health mental well-being. However, research is scarce exploring the associations between hygiene, quality, among CVD

Language: Английский

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Police officer occupational health: a model of organizational constraints, trauma exposure, perceived resources, and agency

Journal of Occupational Medicine and Toxicology, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 18, 2024

Language: Английский

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