Mild motor signs and depression: more than just medication side effects?

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. present study aims assess the association neurological symptoms medications treatment response. Neurological in 790 patients with MDD were correlated outcome. Three hundred ten (39.2%) responders 480 (60.8%) non-responders. 342 (43.3%) presented signs. In whole sample negative associations dystonia rigidity various was observed. Non-response associated dystonia, rigidity, hypokinesia independent from age medications. This highlighted an MMS specific Moreover, non-response treatment, regardless of medication use. may suggest that a subgroup respond less therapy because underlying still undetected disorder.

Language: Английский

Predicted plasma proteomics from genetic scores and treatment outcomes in major depression: a meta-analysis

European Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: 96, P. 17 - 27

Published: May 22, 2025

Language: Английский