Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design DOI Creative Commons
Elena Koning, Cristiano Chaves, Ryan H. Kirkpatrick

et al.

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 27, 2024

Eating disorders (EDs) are a group of debilitating mental illnesses characterized by maladaptive eating behaviors and severe cognitive-emotional dysfunction, directly affecting 1–3% the population. Standard treatments not effective in approximately one third ED cases, representing need for scientific advancement. There is emerging evidence safety efficacy psilocybin-assisted psychotherapy (PAP) to improve treatment outcomes individuals with EDs. However, limited knowledge neurobiological mechanisms underlying therapeutic effects PAP restricts ability confirm its clinical utility. This narrative review presents an overview methodologies used elucidate pathophysiological EDs or psilocybin that could be employed probe correlates EDs, including magnetic resonance imaging molecular neuroimaging techniques, electrophysiological approaches, neuroplasticity markers. Finally, implications these described relation unique features psychedelic study design, challenges, limitations, future directions advance field. paper represents valuable resource scientists during conceptualization design phases stimulates advancement identification interventions serious health conditions impact behaviors, thoughts, emotions, up 3% people worldwide. Current about highlighting new approaches. Psilocybin-assisted option shows promise improving there lack understanding which may support recovery, making it difficult benefits. several research methods help uncover how influences brain approaches The challenges incorporating into also discussed. Together, this advancements development more

Language: Английский

An initiative for living evidence synthesis in clinical psychedelic research DOI
S. Parker Singleton,

Brooke. L. Sevchik,

Simon Vandekar

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: 3(1), P. 3 - 5

Published: Jan. 10, 2025

Language: Английский

Citations

0
Self‐reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities DOI Open Access
Noa Krawczyk, Megan Miller,

Emma Yuanqi Gu

et al.

Addiction, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The opioid crisis continues to exert a tremendous toll in North America, with existing interventions often falling short of addressing ongoing needs. Psychedelics are emerging as possible alternative therapy for mental health and substance use disorders. This study aimed gather insights on how people or considering using psychedelics manage disorder (OUD), these experiences perceived impact what lessons imply future research practice. We conducted qualitative the Reddit online community platform. extracted posts that contained key psychedelic terms from two most subscribed-to subreddits dedicated discussions OUD treatment (r/OpiatesRecovery r/Methadone) 2018 2021. thematically analyzed content 151 relevant their respective comments. Two prominent themes identified were perspectives effectiveness treating OUD, mechanisms through which thought desire opioids. For many, deemed have strong via multiple mechanisms, including alleviating physical symptoms dependence, shifting motivations around opioids underlying problems reasons use. Others saw potential promise exaggerated, acknowledging many eventually return use, even considered dangerous. There appear be diverse effects treat an urgent need controlled studies better understand different they may used context treatments strategies must combined ensure safety effectiveness. Integrating who drugs will help guide toward effective person-centered enhance wellness.

Language: Английский

Citations

0
A review of psychedelics trials completed in depression, informed by European regulatory perspectives DOI Creative Commons

Francisca Silva,

Florence Butlen-Ducuing, Lorenzo Guizzaro

et al.

Neuroscience Applied, Journal Year: 2025, Volume and Issue: unknown, P. 105516 - 105516

Published: Feb. 1, 2025

Language: Английский

Citations

0
Applying the EU regulatory framework for the clinical use of psychedelics DOI
Florence Butlen-Ducuing,

Francisca Silva,

Ivana Silva

et al.

The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

3
Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design DOI Creative Commons
Elena Koning, Cristiano Chaves, Ryan H. Kirkpatrick

et al.

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 27, 2024

Eating disorders (EDs) are a group of debilitating mental illnesses characterized by maladaptive eating behaviors and severe cognitive-emotional dysfunction, directly affecting 1–3% the population. Standard treatments not effective in approximately one third ED cases, representing need for scientific advancement. There is emerging evidence safety efficacy psilocybin-assisted psychotherapy (PAP) to improve treatment outcomes individuals with EDs. However, limited knowledge neurobiological mechanisms underlying therapeutic effects PAP restricts ability confirm its clinical utility. This narrative review presents an overview methodologies used elucidate pathophysiological EDs or psilocybin that could be employed probe correlates EDs, including magnetic resonance imaging molecular neuroimaging techniques, electrophysiological approaches, neuroplasticity markers. Finally, implications these described relation unique features psychedelic study design, challenges, limitations, future directions advance field. paper represents valuable resource scientists during conceptualization design phases stimulates advancement identification interventions serious health conditions impact behaviors, thoughts, emotions, up 3% people worldwide. Current about highlighting new approaches. Psilocybin-assisted option shows promise improving there lack understanding which may support recovery, making it difficult benefits. several research methods help uncover how influences brain approaches The challenges incorporating into also discussed. Together, this advancements development more

Language: Английский

Citations

0