Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1373 - 1373
Published: Nov. 9, 2024
Plant-Derived
Extracellular
Vesicles
extracellular
vesicles
(PDEVs)
from
organic
agriculture
(without
the
use
of
pesticides
and
microbicides)
contain
high
levels
antioxidants.
Organic
PDEVs
have
shown
an
increased
antioxidant
power
compared
to
single
plants,
suggesting
a
synergistic
effect
bioactives
constitutively
expressed
in
fruits.
With
this
study,
we
wanted
investigate
beneficial
effects
mix
on
human
skin
cells.
We
found
detectable
citric
acid,
ascorbic
glutathione,
catalase,
SOD
deriving
five
different
fruits
(grape,
red
orange,
papaya,
pomegranate,
tangerine).
then
treated
H
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 15, 2025
Abstract
Brain
cancer
remains
a
significant
challenge
in
the
field
of
oncology,
primarily
because
its
aggressive
nature
and
limited
treatment
options
available.
Conventional
therapies
often
fall
short
effectively
targeting
tumor
cells,
while
sparing
healthy
brain
tissue
from
collateral
damage.
However,
exosomes
are
now
recognized
as
promising
nanocarriers
for
targeted
drug
delivery.
These
naturally
occurring
extracellular
vesicles
can
cross
blood–brain
barrier
selectively
interact
with
cells.
Utilizing
delivery
vehicles
offers
novel
approach
potential
therapy.
By
encapsulating
therapeutic
agents
within
exosomes,
drugs
be
specifically
to
maximizing
their
impact
whilst
minimizing
damage
tissue.
Furthermore,
modified
display
molecules
that
recognize
bind
further
enhancing
precision
efficacy.
While
exosome-based
show
potential,
scalability,
purification,
clinical
application
challenges
remain.
The
scalability
exosome
production,
modification
techniques
hurdle
must
overcome
translation.
Additionally,
intricate
interactions
between
microenvironment
necessitate
research
optimize
outcomes.
review
explores
applications
future
perspectives
advancing
treatment.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: June 20, 2024
Exosomes,
a
category
of
extracellular
vesicle
(EV),
are
phospholipid
bilayer
structures
ranging
from
30
to
150
nm,
produced
by
various
organisms
through
the
endosomal
pathway.
Recent
studies
have
established
utilization
exosomes
as
nanocarriers
for
drug
distribution
across
therapeutic
areas
including
cancer,
acute
liver
injury,
neuroprotection,
oxidative
stress,
inflammation,
etc.
The
importance
plant-derived
and
exosome
vesicles
derived
mammalian
cells
or
milk,
loaded
with
potent
plant
bioactives
indications
discussed
along
insights
into
future
perspectives.
Moreover,
this
review
provides
detailed
understanding
biogenesis,
their
composition,
classification,
stability
different
types
exosomes,
routes
administration
standard
techniques
used
isolating,
purifying,
characterizing
exosomes.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(16), P. 1331 - 1331
Published: Aug. 8, 2024
Recent
advancements
in
nanomedicine
and
biotechnology
have
unveiled
the
remarkable
potential
of
plant-derived
extracellular
vesicles
(PDEVs)
as
a
novel
promising
approach
for
cancer
treatment.
These
naturally
occurring
nanoscale
particles
exhibit
exceptional
biocompatibility,
targeted
delivery
capabilities,
capacity
to
load
therapeutic
agents,
positioning
them
at
forefront
innovative
therapy
strategies.
PDEVs
are
distinguished
by
their
unique
properties
that
facilitate
tumor
targeting
penetration,
thereby
enhancing
efficacy
drug
systems.
Their
intrinsic
biological
composition
allows
evasion
immune
response,
enabling
efficient
transport
loaded
molecules
directly
sites.
Moreover,
possess
inherent
anti-cancer
properties,
including
ability
induce
cell
cycle
arrest
promote
apoptotic
pathways
within
cells.
also
demonstrated
antimetastatic
effects,
inhibiting
spread
growth
The
multifunctional
nature
simultaneous
multiple
further
potential.
Engineering
modification
techniques,
such
encapsulation,
loading
agents
via
electroporation,
sonication,
incubation,
enabled
customization
improve
efficiency
capacity.
This
includes
surface
modifications
increase
affinity
specific
markers
encapsulation
various
types
small
molecule
drugs,
nucleic
acids,
proteins.
origin
offers
an
abundant
renewable
source
produce
vesicles,
reducing
costs
facilitating
scalability
clinical
applications.
review
provides
in-depth
analysis
latest
research
on
emerging
therapy.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
97, P. 105719 - 105719
Published: April 26, 2024
Acne
is
a
common
inflammatory
skin
disease
caused
by
colonization
of
Propionibacterium
acnes
(P.
acnes),
which
causes
physical
and
psychological
effects
on
the
patients.
The
delivery
active
ingredients
in
ointments
for
treatment
acne
often
limited
need
to
cross
stratum
corneum
capillaries
reach
infected
surface,
resulting
poor
bactericidal
efficacy.
Here,
we
have
successfully
developed
pH-responsive
microneedle
patch
based
Schiff
base,
synergistically
combines
Sodium
houttuyfonat
(SH)
with
N,
O-carboxymethylchitosan
(NOCC).
demonstrates
exceptional
biocompatibility,
mechanical
properties
on-demand
release
performance
through
ratio
optimization.
Drug
study
vitro
demonstrated
its
controlled
drug
capability
eliminate
P.
effectively.
In
mice
model
(Balb/c),
SH-NOCC
enhanced
anti-inflammatory
elimination
capabilities
NF-κB/NLRP3
signaling
pathway.
Together,
these
results
indicated
that
SH-MN
could
be
potential
candidate
anti-acne
treatment.
Frontiers in Plant Science,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 2, 2024
,
a
notorious
phytopathogen,
is
responsible
for
causing
bacterial
wilt,
leading
to
significant
economic
losses
globally
in
many
crops
within
the
Solanaceae
family.
Despite
various
cultural
and
chemical
control
strategies,
managing
wilt
remains
substantial
challenge.
This
study
demonstrates,
first
time,
effective
use
of
plant-induced
gene
silencing
against
Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
7(11)
Published: Aug. 24, 2024
Abstract
Extracellular
vesicles
(EVs)
are
membranous
structures
secreted
by
cells
that
play
important
roles
in
intercellular
communication
and
material
transport.
Due
to
its
excellent
biocompatibility,
lipophilicity,
homing
properties,
EVs
have
been
used
as
a
new
generation
of
drug
delivery
systems
for
the
diagnosis
treatment
tumors.
Despite
potential
clinical
benefits
animal‐derived
extracellular
(AEVs),
their
large‐scale
production
remains
sluggish
due
exorbitant
cost
cell
culture,
challenging
quality
control
measures,
limited
capabilities.
This
constraint
significantly
hinders
widespread
application.
Plant‐derived
(PEVs)
share
similar
functionalities
with
AEVs,
yet
they
hold
several
advantages
including
wide
variety
source
materials,
cost‐effectiveness,
ease
preparation,
enhanced
safety,
more
stable
physicochemical
notable
efficacy.
These
merits
position
PEVs
promising
contenders
broad
biomedical
sector.
review
will
elucidate
PEVs,
delineating
therapeutic
mechanisms
cancer
treatment,
explore
prospective
applications
engineered
targeted
nano‐system
drugs,
microRNAs,
small
interfering
RNAs,
beyond.
The
aim
is
heighten
researchers’
focus
on
expedite
progression
from
fundamental
research
transformation
groundbreaking
discoveries.
Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 13, 2024
Mesenchymal
stroma
cells
derived
from
oral
tissues
are
known
as
dental
stem
(DSCs).
Owing
to
their
unique
therapeutic
niche
and
clinical
accessibility,
DSCs
serve
a
promising
treatment
option
for
bone
defects
tissue
regeneration.
exist
in
hypoxic
microenvironment
