High-dose radiation induces dendritic cells maturation by promoting immunogenic cell death in nasopharyngeal carcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

Due to the radiosensitivity and deep anatomical location of nasopharyngeal carcinoma (NPC), radiotherapy serves as cornerstone standardized treatment for this malignancy. Beyond its cytotoxic effects, can serve an immunological adjuvant by inducing immunogenic cell death (ICD). Dendritic cells (DCs), potent antigen-presenting cells, play a critical role in tumor immunotherapy, but their exact ICD process NPC remains unclear. The effects high-dose radiation (≥2 Gy) on DCs type immune response it elicits have not been fully elucidated. An vitro study was conducted assess whether 5-8F induced could regulate DCs. Specifically, maturation capacity were evaluated following co-culture with exposed radiation. High-dose found induce evidenced increased pro-inflammatory factor levels reduced anti-inflammatory culture supernatant. Co-culture 15 minutes significantly enhanced expression surface molecules DCs, promoting sensitization. radiation-induced apoptosis is form ICD, which plays important regulating DC function. These findings provide insight into immunomodulatory potential enhance immunotherapy through activation.

Language: Английский

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Nanosheets anchored ultrasmall nanoimmunosensitizers-triggered collaborative multienzyme-mimicking cascade reactions disrupt spatiotemporal heterogeneous metabolism to sensitize mastocarcinoma immunotherapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154500 - 154500

Published: Aug. 3, 2024

Language: Английский

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Radiolabelled Nanomaterials for Diagnostic and Therapeutic Applications in Hepatocellular Carcinoma and Other Liver Diseases

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100018 - 100018

Published: Feb. 1, 2025

Language: Английский

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Gold Nanorods (GNRs): A Golden Nano Compass to Navigate Breast Cancer by Multimodal Imaging Approaches

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(2)

Published: Feb. 1, 2025

The ongoing rise in the incidences of breast cancer cases has concerned medical and scientific personnel around world. Adequate treatment predominantly relies on pertinent diagnosis type as well other molecular cellular details at initial stage only. Surprisingly, up till now, there is no single, self-reliant imaging modality that helps to systematically find out anatomical functional events taking place inside body. This resulted advent multimodal concept, which encompasses integration complementary modalities by designing probes. Gold nanorods (GNRs) are extremely popular effective nanoparticles for bioimaging due their unique properties. Researchers have designed varieties stable biocompatible GNR-based probes targeted nontargeted cancer. However, a lack investigations vivo fate toxicity GNRs. Thus, preclinical clinical translation can be attained comprehensively determining review provides about GNRs-based nanoprobes fabricated so far imaging, which, consequent studies, taken usage.

Language: Английский

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Bimetallic MnZnS_X Nanotheranostics for Self‐Activatable Chemo‐Immunotherapy of Hepatocellular Carcinoma via H₂S‐Triggered Arsenic Prodrug Activation and Binary cGAS‐STING Pathway Modulation

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Arsenic trioxide (As2O3) has long been utilized in traditional Chinese medicine due to its therapeutic properties. While it exhibits potent anticancer activity, clinical application is hindered by systemic toxicity and limited tissue specificity. In this study, an advanced approach developed using arsenic prodrug-loaded bimetallic sulfide MnZnSX nanorods (As-MnZnSX NRs) enhance both the efficacy safety of As2O3 hepatocellular carcinoma treatment. These are engineered release Mn2+ H2S within tumor microenvironment, facilitating binary-cooperative activation cGAS-STING pathway. This dual mechanism enhances immune responses while converting prodrug into cytotoxic form, AsIII. The results demonstrate that amplifies pathway inducing TBK1 phosphorylation IRF3 activation, leading dendritic cell maturation improved antigen cross-presentation. Simultaneously, promotes conversion collectively driving binary stimulation strategy significantly augments antitumor integrating modulation with targeted effects. Furthermore, enable vivo MRI, allowing real-time monitoring treatment progression. study represents a substantial advancement liver cancer therapy chemoimmunotherapy diagnostic imaging, thereby improving precision minimizing toxicity.

Language: Английский

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Supramolecular self-assembly of multifunctional carrageenan-based Nanomicelles for effective tumor therapy via apoptosis and immunogenic cell death

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141518 - 141518

Published: Feb. 26, 2025

Language: Английский

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Harnessing the power of nanoagents in acute kidney injury: A versatile platform for imaging and treatment

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216570 - 216570

Published: Feb. 27, 2025

Language: Английский

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Tumor microenvironment-activated and near-infrared light-driven free radicals amplifier for tetra-modal cancer imaging and synergistic treatment

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137208 - 137208

Published: March 1, 2025

Language: Английский

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Surface-modified neodymium selenide nanoparticles for 5-fluorouracil delivery

Journal of Rare Earths, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

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Stimuli-Responsive Prodrugs with Self-Immolative Linker for Improved Cancer Therapy

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116928 - 116928

Published: Sept. 30, 2024

Language: Английский

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