
Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101945 - 101945
Published: Dec. 1, 2024
Language: Английский
Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101945 - 101945
Published: Dec. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 176 - 176
Published: Jan. 30, 2025
Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation tumors while sparing surrounding healthy tissues. Despite its clinical success, proton faces challenges optimizing therapeutic precision and efficacy. Recent research has highlighted potential gold nanoparticles enhance outcomes. Due their high atomic number favorable biological properties, act as radiosensitizers by amplifying generation secondary electrons reactive oxygen species upon irradiation. This enhances DNA damage tumor cells preserving Additionally, functionalization with tumor-targeting ligands offers improved precision, making more effective against broader range cancers. review synthesizes current knowledge on mechanisms nanoparticle radiosensitization, preclinical evidence, technological hurdles that must be addressed integrate this promising approach into practice, aiming advance efficacy accessibility therapy.
Language: Английский
Citations
2Journal of Science Advanced Materials and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100882 - 100882
Published: March 1, 2025
Language: Английский
Citations
0Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100085 - 100085
Published: May 1, 2025
Language: Английский
Citations
0Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: May 12, 2025
Glioblastoma (GBM) poses a formidable challenge because of its high morbidity and mortality. The therapeutic efficacy GBM is significantly hampered by the intricate blood-brain barrier (BBB) tumor (BBTB). Nanomaterial-based brain-targeted delivery systems have shown great potential for effectively delivering agents treatment overcoming limitations conventional drugs, such as poor BBB penetration, short half-life, low bioavailability. This review focuses on an in-depth analysis interplay between BBB/BBTB drug transport kinetics while analyzing innovative nanoparticle-mediated strategies enhanced treatment. Moreover, nanoparticle-based are emphasized, with particular attention given to biomimetic nanoparticles (BMNPs), whose unique advantages. current challenges, translational potential, future research directions in this rapidly evolving field comprehensively discussed, highlighting advances nanomaterial applications. aims stimulate further into systems, offering promising avenues maximizing effects gene drugs or chemotherapeutic practical
Language: Английский
Citations
0Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101945 - 101945
Published: Dec. 1, 2024
Language: Английский
Citations
1