Drug and Chemical Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Nov. 28, 2024
Diphenyl
ether
(DE)
is
a
chemical
compound
being
used
in
number
of
industries
such
as
soap,
detergents,
perfumes,
adhesive,
dyes,
herbicides
and
flame
retardant
plastics,
rubbers
textiles,
etc.
DE
the
final
debromination
product
polybrominated
diphenyl
ethers
(PBDEs)
under
anaerobic
conditions.
The
present
investigation
evaluated
genotoxic,
biochemical,
histopathological,
ultrastructural
(SEM)
biomolecular
(ATR-FTIR)
changes
zebrafish
larvae
after
exposure.
After
determination
96
h
LC
Environmental Sciences Europe,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Feb. 6, 2024
Abstract
Glyphosate
(GLY),
the
most
widely
used
herbicide
active
ingredient
(AI)
in
world,
is
frequently
detected
aquatic
environments
where
it
can
affect
non-target
organisms.
Globally,
more
than
2000
commercial
GLY-based
herbicides
(GBHs)
are
to
control
weeds.
Non-target
organisms
exposed
complex
pesticide
formulations
under
real
environmental
conditions,
but
co-formulants
contained
GBHs
classified
as
so-called
inert
and
inactive
ingredients
terms
of
their
biological
effects.
The
main
objective
this
comprehensive
review
compile
results
ecotoxicological
studies
on
side-effects
GLY,
GBHs,
formulating
agents.
Based
demonstrated
for
a
variety
plant
animal
organisms,
oxidative
stress
appears
be
major
trigger
these
adverse
effects,
affecting
integrity
DNA
other
biochemical
functions.
Furthermore,
there
evidence
impairment
various
physiological
behavioral
Adverse
effects
GLY
have
been
observed
even
at
very
low
concentrations.
There
also
differences
sensitivity
tested,
with
similar
lifestyles,
habitats
or
identical
taxa.
typically
investigate
short-term
single
exposure
GLY/GBH
species,
whilst
reality
multiple
applications
together
pesticides
common
during
cropping
cycle.
Moreover,
interactions
between
GLY/GBHs
contaminants
rarely
studied.
Higher
toxicity
compared
alone
has
often
observed,
demonstrating
that
highly
toxic
own
markedly
increase
GBH
formulation.
possible
impurities
such
heavy
metals,
cause
additional
problems
environment
food
safety.
widespread
massive
use
leads
increased
hazards.
In
addition,
need
revision
risk
assessment
system
emphasized.
According
studies,
current
pollution
by
problematic
cannot
considered
environmentally
sustainable.
It
is,
therefore,
necessary
least
tighten
permitted
forms
use.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 28, 2025
Glyphosate
(GLY)
is
a
well-known
herbicide
with
significant
applications
in
both
agriculture
and
non-agriculture.
However,
GLY
overuse
recent
years
has
resulted
detection
of
residues
many
crops,
endangering
human
health
food
safety.
Our
aim
to
investigate
the
relationship
between
urinary
mortality,
as
well
its
influencing
factors.
The
National
Health
Nutrition
Examination
Survey
(NHANES)
data
from
4740
American
adults
were
examined.
Fitted
smooth
curves,
generalized
summation
models,
multiple
logistic
regression
models
used
mortality.
To
potential
regulatory
elements
two
effects,
perform
subgroup
analysis.
During
median
follow-up
4.03
years,
there
total
238
all-cause
deaths,
75
cardiovascular
disease
(CVD)
deaths
52
cancer
deaths.
positively
correlated
Each
1
ng/ml
increase
was
associated
40%
increased
risk
mortality
(Hazard
ratio
(HR)
1.40,
95%
confidence
interval
(CI)
1.09-1.80),
an
50%
High
group
compared
Low
(HR
1.50,
CI
1.05-2.14).
In
analysis,
association
significantly
modified
by
gender
(P
for
interaction
=
0.03),
hypertension
0.022).
Higher
seems
be
more
death,
may
affect
this
association.
Furthermore,
urine
have
higher
effect
on
people
without
hypertension.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
275, P. 116244 - 116244
Published: March 26, 2024
A
risk
assessment
on
the
aquatic
toxicity
of
plant
biostimulant
strigolactone
mimic
(2-(4-methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-benzo[de]isoquinoline-1,3-dione
(SL-6)
was
performed
using
a
suite
standardised
bioassays
representing
different
trophic
groups
and
acute
chronic
endpoints.
In
freshwater,
three
algae,
crustacea
fish
were
used.
Whilst
in
seawater,
algae
(unicellular
macroalgae),
Crustacea
Mollusca
employed.
addition,
genotoxicity
SL-6
determined
with
comet
unicellular
marine
oysters,
embryos.
This
first
time
ecotoxicity
tests
have
been
SL-6.
lowest
LOEC
measured
at
0.31
mg/L
Although,
similar
values
found
for
embryo
malformations
impacts
hatching
rate
zebrafish
(LOEC
0.31-0.33
mg/L).
Consistent
pericardial
yolk
sac
oedemas
identified
embryos
mg/L.
species,
both
Tisbe
battagliai
mortality
microalgae
growth
an
concentration
1.0
Significant
observed
above
control
levels
0.0031
0.001
oyster
larvae.
When
applying
simple
assessment,
based
NOECs
appropriate
factors,
calculated
predicted
no
effect
(PNEC),
µg/L
0.01
respectively.
