The Future Landscape and Framework of Precision Nutrition DOI Creative Commons
Tianshu Han, Wei Wei, Wenbo Jiang

et al.

Engineering, Journal Year: 2024, Volume and Issue: 42, P. 15 - 25

Published: Feb. 29, 2024

The concept of precision nutrition was first proposed almost a decade ago. Current research in primarily focuses on comprehending individualized variations response to dietary intake, with little attention being given other crucial aspects nutrition. Moreover, there is dearth comprehensive review studies that portray the landscape and framework This commences by tracing historical trajectory nutritional science, aim dissecting challenges encountered science within new era disease profiles. also deconstructs field into four key components: proposal theory for requirement phenotypes; establishment precise methods measuring intake evaluating status; creation multidimensional intervention strategies address what, how, when eat; construction pathway translation integration scientific healthcare practices, utilizing artificial intelligence information platforms. Incorporating these components, this further discusses prospective avenues warrant exploration achieve objective enhancing health through

Language: Английский

Burden of cardiovascular disease among elderly: based on the Global Burden of Disease Study 2019 DOI Creative Commons
Chunrun Qu,

Sheng Liao,

Jingdan Zhang

et al.

European Heart Journal - Quality of Care and Clinical Outcomes, Journal Year: 2023, Volume and Issue: 10(2), P. 143 - 153

Published: June 8, 2023

Abstract Background The burden of elderly cardiovascular disease (CVD) has received increasing attention with population ageing worldwide. Aims We reported on the global CVD in individuals over 70, 1990–2019. Methods and results Based Global Burden Disease Study 2019, data were analysed. Temporal trends analysed joinpoint model. slope index concentration used to evaluate health inequality. From 1990 incidence, prevalence, death, disability-adjusted life year rates generally decreased. However, current remains high. rapid growth parts sub-Saharan Africa Asia is a cause for concern. Countries higher socio-demographic (SDI) have seen greater decrease burden, while countries lower SDI experienced increases or smaller declines burden. Health inequality analysis confirmed that was gradually concentrating towards low SDI. Among different CVDs, ischaemic heart causes greatest individuals. Most burdens increase age, but stroke peripheral vascular show markedly distributional characteristics. In addition, hypertensive shows an unusual shift high-SDI countries. High systolic blood pressure consistently leading risk factor among Conclusion older people severe tends lower-SDI Policymakers need take targeted measures reduce its harm.

Language: Английский

Citations

29
Inclisiran: a new generation of lipid-lowering siRNA therapeutic DOI Creative Commons
Yanzhen Zhang,

Huaigang Chen,

Lang Hong

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 13, 2023

Atherosclerotic heart disease (AHD) is a major cause of morbidity and mortality worldwide. Lowering low-density lipoprotein cholesterol (LDL-C) levels key strategy to prevent treat AHD. Inclisiran novel siRNA drug that targets proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression reduces LDL-C with only two or three injections per year. This review summarizes the mechanism, efficacy, safety, applications in various populations settings, based on recent literature. It also compares other lipid-lowering drugs, especially PCSK9 inhibitors. We conclude promising agent can provide convenience effectiveness for patients high cardiovascular risk. However, some challenges limitations remain Inclisiran, such as its long-term safety cost-effectiveness accessibility, interactions synergies drugs. These issues need further investigation evaluation future studies.

Language: Английский

Citations

27
Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years DOI Open Access
Yuxing Liang, Nan Zhang, Miao Wang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 132 - 132

Published: Dec. 30, 2023

Dietary risk has always been a major factor for colorectal cancer (CRC). However, the contribution of dietary factors to CRC at level region, gender, and age not fully characterized. Based on Global Burden Disease (GBD) 2019 study, death rates, age-standardized mortality rates (ASDRs), estimated annual percentage changes (EAPCs) were calculated assess trends attributable over past 30 years. Globally, cases increased 1,085,797 in 2019, number deaths attributed 365,752 representing approximately one-third all CRC-related fatalities. Overall, ASDR risks was 4.61 per 100,000 with slight downward trend (EAPC = -0.29). Notably, there is rising early-onset associated factors. To alleviate burdens, it recommended elevate intake whole grains, milk, calcium, fiber while reducing consumption red processed meats. The results will improve understanding, provide guidance diet different regions, groups worldwide.

Language: Английский

Citations

25
Global burden and cross-country inequalities in stroke and subtypes attributable to diet from 1990 to 2019 DOI Creative Commons
Xian Chen, Jia Zheng, Jianying Wang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 8, 2024

Abstract Data sources The Global Burden of Diseases, Injuries, and Risk Factors study (GBD) 2019. Background To describe burden, to explore cross-country inequalities according socio-demographic index (SDI) for stroke subtypes attributable diet. Methods Death years lived with disability (YLDs) data corresponding estimated annual percentage changes (EAPCs) were by year, age, gender, location SDI. Pearson correlation analysis was performed evaluate the connections between age-standardized rates (ASRs) death, YLDs, their EAPCs We used ARIMA model predict trend. Slope inequality (SII) relative concentration (RCI) utilized quantify distributive in burden stroke. Results A total 1.74 million deaths (56.17% male) 5.52 YLDs (55.27% female) diet included 2019.Between 1990 2019, number global related poor increased 25.96% 74.76% while ASRs death decreased 42.29% 11.34% respectively. disease generally age. trends varied among subtypes, ischemic (IS) being primary cause intracerebral hemorrhage (ICH) leading death. Mortality is inversely proportional SDI ( R = -0.45, p < 0.001). In terms countries different SDIs exhibited no significant difference 0.15), but SII changed from 38.35 45.18 2019 RCI showed 18.27 24.98 highest appeared Mongolia Vanuatu lowest them Israel Belize, High sodium diets, high red meat consumption, low fruit diets top three contributors Discussion diet-related significantly concerning Countries higher a disproportionately greater its these disparities found intensify over time. reduce it critical enforce improved dietary practices, special emphasis on mortality drop lower incidence decline countries.

Language: Английский

Citations

14
Global burden of cardiovascular disease attributable to metabolic risk factors, 1990–2019: an analysis of observational data from a 2019 Global Burden of Disease study DOI Creative Commons

Shuyi Wu,

Wenlin Xu,

Chengfu Guan

et al.

BMJ Open, Journal Year: 2023, Volume and Issue: 13(5), P. e069397 - e069397

Published: May 1, 2023

Objectives An up-to-date, detailed global analysis of the current status metabolic-attributed cardiovascular disease (CVD) burden has not been reported. Therefore, we investigated CVD and its association with socioeconomic development over past 30 years. Methods Data on were taken from 2019 Global Burden Disease (GBD) study. Metabolic risk factors included high fasting plasma glucose, low-density lipoprotein cholesterol (LDL-c), systolic blood pressure (SBP), body mass index (BMI) kidney dysfunction. Numbers age-standardised rates (ASR) disability-adjusted life-years (DALYs) deaths extracted stratified by sex, age, Socio-demographic Index (SDI) level, country region. Results The ASR DALYs decreased 28.0% (95% UI 23.8% to 32.5%) 30.4% 26.6% 34.5%), respectively, 1990 2019. highest total intracerebral haemorrhage was mainly in low SDI locations, while ischaemic heart IS locations. higher men than women. In addition, number those 80 years old. Conclusion Metabolic-attributed threatens public health, especially low-SDI locations among elderly. Low location should strengthen control metabolic such as SBP, BMI, LDL-c increase knowledge for CVD. Countries regions enhance screening prevention Policy-makers use GBD data guide cost-effective interventions resource allocation.

Language: Английский

Citations

23
The burden of cardiovascular disease attributable to dietary risk factors in the provinces of China, 2002–2018: a nationwide population-based study DOI Creative Commons

Yuehui Fang,

Juan Xia,

Yiyao Lian

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 37, P. 100784 - 100784

Published: May 8, 2023

BackgroundThe burden of cardiovascular diseases (CVDs) is on the rise in China, yet a comprehensive and systematic understanding temporal trends distribution CVD attributable to dietary factors across provinces remains elusive. This study endeavors provide depiction CVDs risk China's geographical regions from 2002 2018.MethodsData China National Nutrition Surveys, Chronic Disease Risk Factor Surveillance, Hypertension Survey, Chinese Centre for Control Prevention cause-of-death reporting system were used estimate intake factor, number deaths, disability-adjusted life years (DALYs), mortality rate, ischemic heart disease (IHD), stroke (IS), hemorrhage other (HOS) at national provincial levels 2018. Using comparative assessment approach, we estimated proportion suboptimal seven factors, both individually collectively, among citizens aged 20 or older.FindingThe mean consumption whole grains, soybeans, nuts, vegetables, fruits, red meat, sugar-sweetened beverages (SSBs) exhibited an upward trend However, with exception meat SSBs, average remained below recommended outlined guidelines. Inadequate fruit, grain, vegetables leading IHD, IS, HOS while soybean, SSB only associated IHD mortality. From 2018, deaths rate diet males greater than that females. With increasing age, diet-related increased substantially. In nationwide was found be 84.5 (95% UI, 84.2–84.9) per 100,000 population 37.3 37.0–37.5) 35.9 35.8–36.2) HOS. Suboptimal responsible 16.0 million 13.8–18.4) DALYs 1137.1 980.4–1312.3) stroke, 13.9 11.8–16.3) 990.2 841.2–1158.6) IHD. Across highest age-standardized rates all observed Shandong (141.1 [95% 140.8–145.2]) Heilongjiang (54.4 52.7–55.9]) Tibet (84.8 80.9–86.5]) The Henan (1.4 1.2–1.6] 1.3 1.1–1.5] IHD).InterpretationThis provides picture geographic variation 2018 highlighting need geographically targeted intervention strategies improve quality reduce CVDs.FundingNational Key Research Development Program (2018YFC1315303), Natural Science Foundation (82103966).

Language: Английский

Citations

19
A Systematic Review of Herbal Interventions for the Management of Cardiovascular Diseases DOI
Ankita Wal, Neha Verma,

Senthil Kumar Balakrishnan

et al.

Current Cardiology Reviews, Journal Year: 2024, Volume and Issue: 20(5)

Published: May 6, 2024

Cardiovascular diseases represent a significant global health burden, necessitating diverse approaches for effective management. Herbal interventions have gained attention as potential adjuncts or alternatives to conventional therapies due their perceived safety and therapeutic potential. This structured abstract provides comprehensive review of herbal the management CVDs, summarising key findings, mechanisms action, clinical implications.

Language: Английский

Citations

5
Metabolic risks remain a serious threat to cardiovascular disease: findings from the Global Burden of Disease Study 2019 DOI

Runhong Li,

Jinang Shao,

Chengxiang Hu

et al.

Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: 19(5), P. 1299 - 1312

Published: April 20, 2024

Language: Английский

Citations

5
The burden of cardiovascular disease attributable to dietary risk factors in Australia between 1990 and 2019 DOI Creative Commons

Sebastian V. Moreno,

Riaz Uddin, Sarah A. McNaughton

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0295231 - e0295231

Published: Jan. 17, 2024

Unhealthy diet is associated with increased risk of cardiovascular diseases (CVD). However, there are no studies reporting the impact and trends dietary factors on CVD in Australia. This study aimed to determine burden CVDs attributable Australia between 1990 2019. We used data from Global Burden Diseases (GBD) quantified rate (per 100,000) deaths, disability-adjusted life years (DALYs), lived a disability (YLDs), lost (YLLs) for 21 13 (eight food groups five nutrients) by sex age (≥25 over). In 2019, age-standardised rates YLDs, YLLs, DALYs Australian population were 26.5, 60.8, 349.9, 410.8 per 100,000 women 46.1, 62.6, 807.0, 869.6 men. Between YLLs consistently contributed more towards than YLDs. Over 30-year period, declined both The leading deaths high red meat (6.1 [3.6, 8.7] 115.6 [79.7, 151.6]) low wholegrains (11.3 [4.4, 15.1] 220.3 [86.4, 291.8]) Sex differences observed contribution over time such that lowest decrease occurred diets sodium processed Although diet-related has decreased significantly past 30 years, continue contribute overall burden. Future nutrition programs policies should target these factors.

Language: Английский

Citations

4
Chronic lead exposure and burden of cardiovascular disease during 1990–2019: a systematic analysis of the global burden of disease study DOI Creative Commons

Pingping Dang,

Manyun Tang,

Heze Fan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 9, 2024

Background Cardiovascular diseases (CVD) are the leading causes of death and disability worldwide. Lead exposure is an important risk factor for CVD. In our study, we aimed to estimate spatial temporal trends in burden cardiovascular disease associated with chronic lead exposure. Methods The data collected study were obtained from Global Burden Disease (GBD) 2019 analyzed by age, sex, cause, location. To assess CVD attributable over 30 years, used Joinpoint regression analysis. Results 2019, number exposure-attributable deaths disability-adjusted life-years (DALYs) 0.85 17.73 million, 1.7 1.4 times more than those observed 1990, respectively. However, corresponding age-standardized rates (ASR) DALY gradually decreased 1990 especially 2013 2019. Over last among 21 GBD regions 204 countries territories, High-income Asia Pacific Republic Korea experienced largest reductions rates, while Central Afghanistan increases. Males elderly population suffered higher burdens females young population. Furthermore, that socio-demographic index (SDI) demonstrated lower ASR rates. low low-middle SDI regions, South Asia, exhibited highest Conclusion Our provides a thorough understanding findings confirm significance implementing mitigation strategies increasing investment prevention treatment. These measures crucial reducing promoting public health on global scale.

Language: Английский

Citations

4