The role of the advanced lung cancer inflammation index (ALI) in the risk of liver fibrosis and mortality among US adult MAFLD patients: a cross-sectional study of NHANES 1999–2018

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 20, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic globally, with inflammation and nutrition playing key roles in its progression. The Advanced Lung Cancer Inflammation Index (ALI) novel biomarker reflecting nutritional inflammatory status. This study aims to explore the association between ALI risk of fibrosis prognosis MAFLD patients. cross-sectional analyzed NHANES data from 1999–2018 on adult participants US. Weighted logistic regression assessed risk. Mortality outcomes, including all-cause, cardiovascular (CVD), cancer mortality, using weighted Kaplan-Meier Cox proportional hazards models. Restricted cubic splines (RCS) threshold effect analyses were uesd non-linear relationships. Receiver operating characteristic (ROC) curve evaluated prognostic value ALI, stratified examined subgroup differences. A total 6,858 patients (mean age 51.38 ± 17.22 years, 54% male) included. relationship was found risk, at 5.68, beyond which increased significantly (OR = 2.35, 95% CI: 1.89–2.95). Stronger associations observed subgroups central obesity prediabetes (P for interaction < 0.05). inversely associated all-cause mortality (HR 0.64, 0.56–0.72) CVD 0.57, 0.46–0.65), but not mortality. RCS analysis showed an L-shaped (threshold 5.36) linear Low HDL cholesterol excessive alcohol consumption influenced demonstrated highest predictive accuracy reduced highlighting potential assessing prognosis, particularly CVD-related

Language: Английский

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Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in metabolic dysfunction associated steatotic liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 29, 2025

Language: Английский

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Systemic inflammatory indices and the risk of depression in individuals with sleep difficulties: A cohort study based on NHANES 2005-2020

Comprehensive Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 100299 - 100299

Published: May 1, 2025

Language: Английский

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Developing and validating a predictive model for all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 20, 2025

This study aimed to construct a scientific, accurate, and readily applicable clinical all-cause mortality prediction model for patients with metabolic dysfunction-associated steatotic liver disease (MASLD) enhance the efficiency of management improve patient prognosis. was retrospective cohort based on National Health Nutrition Examination Survey database. The 17,861 participants diagnosed MASLD were randomly assigned either training (n = 12,503) or validation 5358). Potential predictors subjected LASSO regression analysis, independent risk factors subsequently identified through multivariate Cox analysis. An constructed significant predictors, nomogram generated illustrate survival probability at various time points. model's performance evaluated using receiver operating characteristic (ROC), calibration, decision curve analysis (DCA) curves. A multiple several significantly influencing in MASLD. These included gender, age, smoking status, hypertension, red blood cell count, albumin, glutamyl transpeptidase, glycosylated hemoglobin, creatinine. predictive demonstrated high accuracy cohorts, AUC values approaching 0.85 3, 5, 10 years, respectively. Calibration DCA curves employed verify stability generalizability model. We successfully validated an patients. provides powerful tool assessment treatment decision-making.

Language: Английский

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Comment on “The systemic inflammation response index as a risk factor for hepatic fibrosis and long-term mortality among individuals with metabolic dysfunction-associated steatotic liver disease”

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(12), P. 2844 - 2845

Published: Aug. 5, 2024

Language: Английский

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