High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1468 - 1468

Published: Nov. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Language: Английский

Prevalence and association of metabolism-associated steatotic liver disease across age groups and gender DOI
Salvatore Corrao,

Salvatore Scibetta,

Serena Scardina

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103926 - 103926

Published: Feb. 1, 2025

Language: Английский

Citations

0
The fundamental role of mitochondria–endoplasmic reticulum contacts in ageing and declining healthspan DOI Creative Commons
Richard M. Monaghan

Open Biology, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

This open question research article highlights mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), which have emerged as crucial cellular structures that challenge our traditional understanding of organelle function. review the critical importance MAMs a frontier in cell biology with far-reaching implications for health, disease and ageing. serve dynamic communication hubs between ER mitochondria, orchestrating essential processes such calcium signalling, lipid metabolism stress responses. Recent has implicated MAM dysfunction wide array conditions, including neurodegenerative diseases, metabolic disorders, cardiovascular diseases cancer. The significant lack biological knowledge behind function emphasizes need to study these enigmatic subcellular sites greater detail. Key questions include mechanisms controlling formation disassembly, full complement MAM-associated proteins how contribute decision-making ageing processes. Advancing through interdisciplinary approaches cutting-edge technologies promises reveal new insights into fundamental signalling pathways potentially lead innovative therapeutic strategies range diseases. As such, represents potential transform life human health.

Language: Английский

Citations

0
High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1468 - 1468

Published: Nov. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Language: Английский

Citations

1