Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 DOI Creative Commons

Li-Xin Yun,

Wen-Sheng Huang,

Changjing He

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Systemic inflammation contributes to the progression of heart failure (HF). This study aims investigate association between inflammatory burden index (IBI) and HF risk. In this cross-sectional NHANES 2003-2017, data from 19,856 participants were analyzed, including 652 with 19,204 without HF. Participants categorized into quartiles based on IBI levels (Q1-Q4). The risk across these was assessed adjustment for potential confounders restricted cubic spline analyses used evaluate dose-response relationships. Our results show that have higher compared those (2.66 ± 0.27 vs. 1.05 0.03, p < 0.001). prevalence increases quartiles: Quartile 1 (1.2%), 2 (1.33%), 3 (2.60%), 4 (4.37%) (p After adjusting confounders, remained elevated (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.48-1.10), (OR 1.06, CI: 0.70-1.61), 1.46, 1.02-2.10) 1. Restricted analysis further confirmed a substantial positive-linear correlation Higher are related high HF, independent traditional factors. These suggest could be useful parameter identifying individuals at Not applicable.

Language: Английский

Low-Density Lipoprotein Subfraction Phenotype Is Associated with Epicardial Adipose Tissue Volume in Type 2 Diabetes DOI Open Access
José Rives, Pedro Gil, David Viladés-Medel

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 862 - 862

Published: Jan. 28, 2025

Background: Increased epicardial adipose tissue (EAT) volume is a common feature in type 2 diabetes (T2DM) which directly associated with heart failure and advanced atherosclerosis. We aimed to evaluate lipoprotein-related biomarkers of EAT T2DM patients before after glycemic control. Methods: This study included 36 optimization control on 14 healthy controls (HCs). was measured using computed tomography imaging indexed the body surface area (iEAT). Biochemical lipid profiles were determined commercial methods. Lipoproteins isolated by ultracentrifugation, variables lipoprotein function assessed. Multivariable regression analysis used find independently iEAT. Results: iEAT higher than decreased optimization. HDLs from had less apoA-I cholesterol more apoC-III triglycerides. LDLs triglycerides apoB smaller sizes those HCs. Significant correlations found between age, BMI, HbA1c, GGT, VLDLc, triglycerides, LDL size, HDL, HDL. In multivariable analysis, GGT associations remained statistically significant, predicted 50% variability volume. ROC these showed an AUC 0.835. Conclusions: Qualitative characteristics lipoproteins altered T2DM. that size plasma levels volume, suggesting might be useful for stratifying increased

Language: Английский

Citations

1
Eligibility for and practical implications of Semaglutide in overweight and obese patients with acute coronary syndrome DOI Creative Commons
Vincenzo De Sio, Felice Gragnano,

Antonio Capolongo

et al.

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: 423, P. 133028 - 133028

Published: Jan. 29, 2025

Language: Английский

Citations

1
A Longitudinal Cohort Assessing the Carotid Intima-Media Thickness Progression and Cardiovascular Risk Factors in a Rural Black South African Community DOI Open Access

Given Mashaba,

Wendy N. Phoswa, Sogolo Lucky Lebelo

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 1033 - 1033

Published: Feb. 6, 2025

Background: Diabetes mellitus [DM) is a fast-increasing non-communicable disease in South Africa, with prevalence of 11.3%. The present study aimed to longitudinally investigate the association carotid intima-media thickness [CIMT) progression and cardiovascular risk factors T2DM non-DM rural black population Africa. Methods: This population-based retrospective cohort was conducted Dikgale Mamabolo Mothiba Surveillance area between 2014 2023 by Africa Wits INDEPTH Partnership for Genomic Research (AWI-Gen). IBM Statistical Package Social Sciences version 27 used analyze data. paired T-test determine mean differences baseline follow-up. Longitudinal estimates CIMT CVD groups were analyzed using linear mixed models. Results: age 51.64 years. There significant increase (left CIMT), low-density lipoprotein-cholesterol (LDL-C), systolic blood pressure (SBP), diastolic (DBP), pulse rate groups. In group, there strong (2.20 mm), LDL-C (4.30 SBP (4.57 waist/hip ratio (0.24 mm) progression. group revealed (0.001 (1.41 Conclusion: associated other main CVD-related (age, LDL-C, LDL-C/HDL-C ratio, TC/HDL-C SBP). more pronounced than non-DM, suggesting higher atherosclerosis complications individuals.

Language: Английский

Citations

1
Screening for Subclinical Atherosclerosis in Patients with Familial Hypercholesterolemia: Insights and Implications DOI Open Access
Muhammed Furkan Deniz, Barış Güven, Abdullah Ömer Ebeoğlu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 656 - 656

Published: Jan. 20, 2025

Background/Objectives: Familial hypercholesterolemia (FH) is a monogenic dyslipidemia that leads to early cardiovascular events. Subclinical atherosclerosis refers the formation of atheromatous plaques in arterial beds before any clinical In our study, we investigated presence, extent, and independent predictors subclinical among patients diagnosed with FH. Methods: This was single-center, prospective, cross-sectional study. original study included 215 FH from cohort 1145 individuals assessed according Dutch Lipid Clinical Network (DLCN) criteria. Carotid femoral ultrasonography were performed, coronary artery calcium score measured screen for atherosclerosis. Apolipoprotein A-I, apolipoprotein B, lipoprotein (a) analyzed using nephelometric method. Results: The comprised 136 females (63%) mean age 54 (43–62) years. stigmata rate 18%. statin use during screening 32% only eight (4%) attained LDL-C values < 70 mg/dL. observed 148 (69%), rates 48%, 47.5%, 40.5% arteries, carotid bifurcation, respectively. Advanced age, male sex, high pretreatment low-density lipoprotein-cholesterol (LDL-C) level, diabetes, low Apo A-I/Apo B ratio identified as Lp(a) levels ≥ 30 mg/dL predicted atherosclerosis, while diabetes ratios smoking Conclusions: prevalent, medication adherence remains suboptimal patients. Screening may impact treatment strategies, via an increase physician commitment protocols improving patient compliance.

Language: Английский

Citations

0
Lipoprotein(a) molar concentrations rather than genetic variants better predict coronary artery disease risk and severity in Han Chinese population DOI Creative Commons
Jie Li,

Ben Ma,

Qin Fang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

It is well established that increased lipoprotein(a) [Lp(a)] a significant risk factor for coronary artery disease (CAD). Plasma Lp(a) levels are genetically determined and vary widely between different races, regions individuals. However, most studies on associated genetic variants have focused the Caucasian population currently. Our study aimed to test associations among LPA variants, concentrations, CAD in Han Chinese cohort. A total of 3779 patients undergoing angiography were recruited from Tongji Hospital. Kringle IV type 2 (KIV-2) copies detected using TaqMan probe real-time quantitative polymerase chain reaction (qPCR) analysis fifteen single nucleotide polymorphisms (SNPs) within gene genotyping analysis. score (GRS) was computed based seven SNPs with Lp(a). Associations evaluated linear regression analyses Logistic analyses, respectively. Compared first quartile Lp(a), fourth exhibited association [odds ratio (OR): 2.08, 95% confidence interval (CI): 1.67-2.59, p < 0.001], multivessel [OR: 2.54, CI: 2.06-3.12, high Gensini scores 2.17, 1.77-2.66, 0.001] after multivariable adjustment cardiovascular factors. Both GRS KIV-2 quartiles concentrations (both trend 0.001). false discovery rate (FDR) correction, there no CAD, or scores. findings indicate can affect levels, but do not exceed molar predict incidence severity usefully, highlighting importance detection management.

Language: Английский

Citations

0
The metabolism of big endothelin-1 axis and lipids affects carotid atherosclerotic plaque stability – the possible opposite effects of treatment with statins and aspirin DOI Creative Commons
Adam Płoński, Anna Krupa, Dariusz Pawlak

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Effects of residual inflammatory and cholesterol risks on cardiovascular events with evolocumab in patients with acute coronary syndrome undergoing percutaneous coronary intervention DOI Creative Commons
Yanyun Zhang, K. Li, Xiangwei Bo

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 31, 2025

Evolocumab has shown significant reductions in low-density lipoprotein cholesterol (LDL-C) levels and incident cardiovascular events among acute coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI). Nonetheless, the potential modification of evolocumab's effectiveness by baseline inflammatory risk remains unclear. We aimed to assess based on neutrophil-to-lymphocyte ratio (NLR) evaluate residual cholesterol-related risks across varying on-treatment NLR LDL-C levels. This multicentric, retrospective analysis enrolled consecutive with ACS PCI exhibiting elevated at First Affiliated Hospital Zhengzhou University Zhongda Southeast between March 2019 August 2021. Patients were categorized into evolocumab standard-of-care treatment groups administration. Hazard ratios for primary composite outcome—including myocardial infarction, ischemic stroke, cardiac death, unplanned revascularization, hospitalization due unstable angina—comparing quartiles computed using multivariable Cox regression. assessed impact outcome median-based dichotomization evaluated 1-month The median was 2.99 (IQR: 2.14–4.69), remaining stable following therapy. Each quartile increase heightened 29% (95% CI, 17–42%; P < 0.01). relative consistent categories (P-interaction > 0.05), but absolute higher high-NLR (2.9% vs. 6.2%). Residual risks, indicated LDL-C, independently correlated (P 0.001). Higher is associated increased ACS/PCI patients. Relative categories, while more Minimized observed lowest 1. Neutrophil-to-lymphocyte predicts post-PCI. 2. from NLR. 3. Absolute 4. On-treatment predict adverse events. 5. Cardiovascular minimized

Language: Английский

Citations

0
Age, inflammation, alkaline phosphatase, and coronary artery calcification in firefighters DOI Creative Commons
Mingyue Li, Jiali Han, Carolyn M. Muegge

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Firefighting involves exposure to hazardous conditions that may contribute adverse long term health outcomes, including cardiovascular disease. While coronary artery disease (CAD) is a leading cause of morbidity among firefighters, the specific occupational contributions Coronary Artery Calcification (CAC), reliable predictor CAD, are not well understood. We conducted cross-sectional study involving 410 aged 35-68, who underwent comprehensive assessments, CAC measurement using computed tomography. Multiple logistic regression models were built examine associations demographic, lifestyle, and clinical variables with score. Our analysis revealed statistically significant between several indicators Age (odds ratio (OR): 1.12; 95% confidence interval (95% CI): [1.05, 1.19]) percentage monocytes (OR: 1.29; CI: [1.06, 1.58]) positively correlated higher score, highlighting role inflammation in CAD firefighters. Moreover, enzyme alkaline phosphatase emerged as an independent score 1.02; [1.01, 1.04]), suggesting novel biomarker risk this population. identified factors associated increased age, inflammation, phosphatase. These findings underscore importance tailored monitoring interventions mitigate considering both general occupation-specific factors. This contributes better understanding challenges faced by firefighters provides foundation for future research preventive strategies high-risk group.

Language: Английский

Citations

0
Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 DOI Creative Commons

Li-Xin Yun,

Wen-Sheng Huang,

Changjing He

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Systemic inflammation contributes to the progression of heart failure (HF). This study aims investigate association between inflammatory burden index (IBI) and HF risk. In this cross-sectional NHANES 2003-2017, data from 19,856 participants were analyzed, including 652 with 19,204 without HF. Participants categorized into quartiles based on IBI levels (Q1-Q4). The risk across these was assessed adjustment for potential confounders restricted cubic spline analyses used evaluate dose-response relationships. Our results show that have higher compared those (2.66 ± 0.27 vs. 1.05 0.03, p < 0.001). prevalence increases quartiles: Quartile 1 (1.2%), 2 (1.33%), 3 (2.60%), 4 (4.37%) (p After adjusting confounders, remained elevated (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.48-1.10), (OR 1.06, CI: 0.70-1.61), 1.46, 1.02-2.10) 1. Restricted analysis further confirmed a substantial positive-linear correlation Higher are related high HF, independent traditional factors. These suggest could be useful parameter identifying individuals at Not applicable.

Language: Английский

Citations

0