Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2814 - 2814

Published: Dec. 14, 2024

The World Health Organization in 2021 ranked Alzheimer’s disease and other dementias as the seventh leading cause of death globally. Neurodegenerative disorders are progressive, intractable, often fatal diseases. Early diagnosis may allow patients to enjoy prolonged survival with attenuated symptomatology because early intervention. Hence, further research on finding non-invasive biomarkers neurodegenerative diseases is warranted. Apolipoprotein D (ApoD) a glycoprotein involved lipid metabolism, oxidative stress regulation, inflammation. It expressed various body fluids regions central nervous system. ApoD’s roles neuroprotection, transport, anti-inflammatory processes crucial far prevention pathologies concerned. This review aims summarize background knowledge ApoD, it covers studies indexed PubMed, Scopus, Web Science databases. discusses evidence for multifaceted ApoD mechanisms pathogenesis multiple sclerosis, disease, Parkinson’s disease. be specific, sensitive, easily obtained, cost-effective biomarker its applications diagnostic practices, treatment strategies, advancing disorders’ management.

Language: Английский