Fructose Intake and Unhealthy Eating Habits Are Associated with MASLD in Pediatric Obesity: A Cross-Sectional Pilot Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 631 - 631

Published: Feb. 10, 2025

Background/Objectives: Fructose consumption in children is increasing, as the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Despite evidence linking added sugars to syndrome, fructose's impact on youth remains unclear, especially pediatrics. Our study aimed evaluate role fructose intake and dysfunction a cohort pre-school adolescents with obesity. Methods: We recruited 41 obesity (age range: 2.5-16 years, BMI SDS 2.6 ± 0.5 kg/m2). Clinical biochemical parameters were assessed. Through ultrasound (US), MASLD, hepatorenal index (HRI), subcutaneous adipose tissue (scAT), visceral (vAT) Dietary was evaluated using IDEFICS FFQ fructose-specific questionnaire. Results: Pubertal subjects had more scAT vAT, higher insulin resistance, fibrosis than those prepubertal. MASLD detected 12 subjects, associated vAT. lower weekly prepubertal (p < 0.02). However, they consumed less from fruits 0.04) other younger children. Patients reported 0.01), primarily 0.003), likely due misreporting, alongside unhealthy food, mainly rich saturated fats. Conclusions: dietary habits Advice pay attention foods fats mandatory decrease both MASLD. Further high-powered studies any pediatric age different geographical areas are needed better history.

Language: Английский

The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 663 - 663

Published: Feb. 13, 2025

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in the liver and, to lesser extent, adipose tissue. While hepatic DNL highly responsive dietary carbohydrate intake and regulated by insulin via transcription factors like SREBP-1c, more modest less sensitive overfeeding. Dysregulated contributes disorders, including dysfunction-associated steatotic disease (MASLD). Lifestyle interventions, such as physical exercise, ketogenic diets, time-restricted eating (TRE) offer promising strategies regulate improve health. Physical exercise enhances glucose uptake muscles, reduces levels, promotes lipid oxidation, thereby suppressing DNL. Endurance resistance training also mitochondrial function, further mitigating triglyceride accumulation. Ketogenic diets shift energy metabolism toward acid oxidation ketogenesis, lower insulin, directly downregulate lipogenic enzyme activity liver. TRE aligns feeding with circadian rhythms optimizing AMP-activated protein kinase (AMPK) activation during fasting periods, which suppresses metabolism. The combined effects of these interventions demonstrate significant potential for improving profiles, reducing triglycerides, preventing lipotoxicity. By addressing distinct roles DNL, target systemic localized dysregulation. Although research needed fully understand their long-term impact, findings highlight transformative integrating approaches clinical practice manage disorders associated complications.

Language: Английский

Fermented Gold Kiwifruit Protects Mice Against Non-Alcoholic Fatty Liver Disease in a High-Fat Diet Model

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(24), P. 11503 - 11503

Published: Dec. 10, 2024

Gold kiwifruit is known for its high vitamin C content and various benefits. This study investigated the effects molecular mechanisms of fermented gold (FGK) in a mouse model high-fat diet (HFD)-induced obesity hepatic steatosis. FGK powder was prepared using five strains lactic acid bacteria: L. paracasei, Lc. lactis, acidophilus, casei, helveticus. ICR mice were fed an HFD 8 weeks to induce steatosis, supplementation evaluated therapeutic potential. administration significantly reduced serum levels alanine aminotransferase (ALT), aspartate (AST), total cholesterol, triglyceride, glucose compared HFD-only group. Histopathological analysis showed that lipid accumulation lesions, as confirmed by hematoxylin eosin (H&E) staining. Furthermore, activated sirtuin 1(SIRT1)/adenosine monophosphate-activated protein kinase (AMPK) pathway inhibited expression pro-inflammatory cytokines such IL-1β, IL-6, TNF-α liver tissue. These findings suggest could reduce severity non-alcoholic fatty disease (NAFLD) inhibiting fat synthesis, promoting breakdown, suppressing inflammation HFD-induced obese mice.

Language: Английский