β-Glucan from Lyophyllum decastes regulates gut microbiota and plasma metabolites in high-fat diet-induced obese mice

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106166 - 106166

Published: April 10, 2024

This study aimed to investigate the effects of Lyophyllum decastes β-glucan (LDBG) in preventing high-fat diet (HFD)-induced obesity male C57BL/6 mice, focusing on fecal gut microbiota (GM) and plasma metabolomics. LDBG treatment led a reduction body weight an improvement dyslipidemia HFD-fed mice. Additionally, decreased pro-inflammatory factors (TNF-α, IL-1β, IL-6) liver abdominal adipose tissue lowered lipopolysaccharide leptin levels plasma. also up-regulated mRNA intestinal epithelial tight junction proteins, such as Occludin, Claudin-1, zonula occludens-1 colon tissue. Furthermore, 16S rRNA gene sequencing data suggested that reduced relative abundance Faecalibaculum Ileibacterium while increasing Bifidobacterium Oscillospiraceae. Untargeted metabolomics showed significantly promoted Tryptophan metabolism, Glycerophospholipid Citrate cycle, closely correlating with GM changes, particularly Oscillospiraceae genera. demonstrates potential prebiotic prevention by regulating metabolite pathways.

Language: Английский

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Lacticaseibacillus paracasei CCFM1222 Ameliorated the Intestinal Barrier and Regulated Gut Microbiota in Mice with Dextran Sulfate Sodium-Induced Colitis

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Language: Английский

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Impact of Lactobacillaceae supplementation on the multi-organ axis during MASLD

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122948 - 122948

Published: Aug. 6, 2024

The gut-liver axis plays a pivotal role in maintaining body homeostasis. Disruption of the is linked to multitude diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Probiotic strains from Lactobacillaceae family are commonly used mitigate experimental MASLD. Over years, numerous studies have demonstrated efficacy these probiotics, often focusing on outcome disease. This review aims further understand MASLD as systemic dysfunction and highlight effects probiotics multi-organ axis, organs such gastrointestinal tract, pancreas, muscle, adipose tissue, immune system. We specifically discuss evidence how supplementation with may alleviate by not only restoring health but also modulating physiology other organ systems.

Language: Английский

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Effects of Lacticaseibacillus paracasei SNB-derived postbiotic components on intestinal barrier dysfunction and composition of gut microbiota

Food Research International, Journal Year: 2023, Volume and Issue: 175, P. 113773 - 113773

Published: Nov. 25, 2023

Language: Английский

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The Role of Diet, Additives, and Antibiotics in Metabolic Endotoxemia and Chronic Diseases

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 704 - 704

Published: Dec. 13, 2024

Background/Objectives: Dietary patterns, including high-fat and high-carbohydrate diets (HFDs HCDs), as well non-dietary factors such food additives antibiotics, are strongly linked to metabolic endotoxemia, a critical driver of low-grade chronic inflammation. This review explores the mechanisms through which these impair intestinal permeability, disrupt gut microbial balance, facilitate lipopolysaccharide (LPS) translocation into bloodstream, contributing disorders obesity, type 2 diabetes mellitus, inflammatory bowel disease. Methods: The analysis integrates findings from recent studies on effects dietary components microbiota interactions barrier function systemic Focus is given experimental designs assessing permeability using biochemical histological methods, alongside profiling in both human animal models. Results: HFDs HCDs were shown increase LPS levels, inducing dysbiosis compromising integrity. resulting endotoxemia promoted state inflammation, disrupting regulation pathogenesis various diseases. Food antibiotics further exacerbated by altering composition increasing permeability. Conclusions: Diet-induced alterations dysfunction emerge key mediators related disorders. Addressing patterns their impact health crucial for developing targeted interventions. Further research warranted standardize methodologies elucidate translating clinical applications.

Language: Английский

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Beneficial Effect of Lactiplantibacillus pentosus on Oxidative Stress and Histopathology in High-Fat-Induced Mice

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 94 - 102

Published: Jan. 27, 2025

Probiotics have been widely used to treat lipid metabolism disorders associated with obesity by modifying the microbiota balance. play a role in health maintaining intestinal homeostasis, alienating pathogens, increasing nutrient bioavailability, and stimulating modulating immune system. Various local probiotics also developed as source of assist issues. One is probiotic Lactoplantibacilus pentosus, which comes from dadih (traditional fermented buffalo milk West Sumatera ). This research aimed assess impact pentosus on oxidative stress, adipose tissue, liver histopathology mice fed high-fat diet (HFD). Methods: The experimental setup involved dividing into four groups, each consisting seven animals. These groups were randomly assigned one dietary regimens: ND (Normal Diet), HFD (High Fat HFDL Diet supplemented L. at 109 CFU/ml), HDLFL containing CFU/ml). In was delivered orally once day for six weeks 1 x CFU/mL dosage. Result: Following 6-week diet, group had 24.30% higher body weight than group. exhibited lower (23.78±0.84g) compared (26.59 ± 1.17g), statistically significant difference (p<0.05). Animals given antioxidant SOD levels MDA Adipocyte hypertrophy, observed animals mitigated administration Lactobacillus pentosus. steatosis, inflammation, fibrosis, necrosis normal Steatosis, necrosis, fibrotic scores decreased Lactiplantibacillus milk. Conclusion: derived has shown reduce obesity, hepatic stress people who regularly consume diets.

Language: Английский

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Supplementation of mixed Lactobacillus alleviates metabolic impairment, inflammation, and dysbiosis of the gut microbiota in an obese mouse model

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Introduction Obesity is a complex metabolic disease, which often accompanied with impaired glucose and lipid metabolism chronic inflammation. Probiotics have been considered as strategy for treating obesity, while the genus of Lactobacillus most commonly tested approved probiotics. Some multi-strain probiotics were proven to produce synergistic effects on obesity compared mono-strain ones. Methods The purpose this study was investigate anti-obesity effect new probiotic formation contained plantarum L14, paracasei L9, rhamnosus GG, sakei X-MRS-2, designated L-PPRS. Multi-strain L-PPRS shown better antiadipogenic than in 3T3-L1 cell. Subsequently, orally supplemented high-fat diet (HFD) induced obese mouse model two kinds treatment course, short-term (8 weeks) one long-term (12 one. Results We found that intervention not only significantly inhibited weight gain HFD-fed mice, but also improved tolerance, insulin sensitivity reduced serum levels. Furthermore, fat accumulation adipose tissue liver, ameliorated antioxidant capacity liver mice. modulated expression lipid-metabolic genes, exhibited excellent anti-inflammatory effect. In addition, restored dysbiosis gut microbiota via reducing Firmicutes/ Bacteroidetes ratio, increasing abundance beneficial intestinal bacteria. conclusion, proved could effectively prevent development its associated abnormalities, supplementation provided more profound benefit short-term. Discussion This highlights potential an effective strategy.

Language: Английский

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Effects of a Sorghum Beverage with Lacticaseibacillus paracasei on Body Composition, Lipid Profiles, and Intestinal Health in Overweight and Obese Adults: A Randomized Single-Blind Pilot Study

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3128 - 3128

Published: Sept. 30, 2024

(1) Background: This study aimed to evaluate the effect of an extruded whole-grain sorghum beverage containing

Language: Английский

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Obesity theranostics using nanoemulsions of probiotics and local herbs

Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 30(10), P. 103790 - 103790

Published: Aug. 23, 2023

Obesity is a polygenic disorder which has become global epidemic in recent years. Aim of the present study was to assess theranostic potential probiotics (Lactobacillus bulgaricus, Bifidobacterium) and local herbs (fenugreek seeds, aloe vera) on body weight, biochemical (liver kidney functions) histology some internal organs (liver, kidney, ovary, small intestine) obese rats. In study, nanoemulsions were formulated by high energy method characterized FTIR UV analysis. One hundred sixty (1 6 0) female wistar rats divided into sixteen groups. A high-fat diet given induce obesity them. Obese treated with different doses probiotics, their combination. Weekly weight monitored. Rats dissected after fifteen weeks; blood harvested for analysis histology. Results demonstrated protective effect nanoemulsion central vein, glomerulus, villi normal ovulatory function combination exhibited improved levels bilirubin (4 mg/dl to15 mg/dl), AST from (110 U/L 18 U/L) ALT (52 10U/L). Similar renoprotective effects recorded overall renal tests (RFT). post treatment urea (63 22 mg/dl) creatinine (0.2 0.8 levels. It therefore evident that reverse parameters histological architecture liver, intestine ovary. The results indicated have positive own, but when combined herbs, they produced highly effective can be used as complementary option individuals.

Language: Английский

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Effect of probiotics on the obese patient. A review study

Salud Ciencia y Tecnología - Serie de Conferencias, Journal Year: 2023, Volume and Issue: 2, P. 549 - 549

Published: Dec. 20, 2023

Introduction: the gut microbiota is a potential determining factor in development of obesity, resulting dysbiosis, which related to lower number members Bacteroidetes division and an increase Firmicutes leading decrease energy expenditure, it also associated with inflammatory process, insulin resistance type 2 diabetes mellitus. Objective: conduct literature review effects probiotics on improvement intestinal obese patient its disorders. Methods: search articles PubMed, Google Scholar Elsevier from last five years was conducted using terms "obesity probiotics", "effect "gut probiotics". A total 23 were included selection criteria. Results: supplementation specifically certain strains such as Lactobacillus plantarum Bifidobacterium could lead significant weight reductions, combination restriction physical activity. However, important develop clinical trials that are properly designed, including all aspects lifestyle, microbiota, metabolites, genetic background. Conclusions: despite beneficial effects, they not yet considered alternative strategy treatment obesity due lack research this field, since currently available data come studies animals may present humans. It more large-scale longitudinal longer follow-up.

Language: Английский

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