Amomum tsao‐ko Attenuates Hyperglycemia and Cognitive Impairment via Regulating Gut Microbiota, SCFAs, and CREB/BDNF/TrkB Signaling Pathway in T2DM Mice DOI
Caixia Wang,

Huilin Ren,

Zhen Wang

et al.

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Background As a medicine‐food fruit, Amomum tsao‐ko has been reported to be beneficial for the management of diabetes. However, its effects and mechanisms in cognitive impairment caused by diabetes remain unclear. This study aimed investigate influences A. on type 2 mellitus (T2DM) mice associated mechanisms. Methods was characterized using UHPLC‐Q‐Orbitrap‐MS/MS. T2DM induced high‐fat diet combined with streptozotocin were treated ethanol extract (EEAT) 8 weeks. The function evaluated Morris water maze (MWM) test, open field test (OFT), novel object recognition (NORT). Hippocampus colon tissues used histopathology, biochemical assays, or protein expression analysis. Additionally, fecal samples subjected 16S rRNA gene sequencing short‐chain fatty acids (SCFAs) detection. Key Results findings demonstrated that EEAT significantly reversed glucose metabolism disorders deficits mice. It promoted CREB/BDNF/TrkB pathway reduced hippocampal inflammatory responses, thereby improving neuronal damage. inhibited loss colonic tight junction proteins, decreased levels factors colon, also reshaped gut microbiota increased SCFAs. Notably, Spearman's correlation analysis indicated Lachnospiraceae NK4A136 group , Ruminococcaceae UCG‐014 Lactobacillus Blautia Lachnoclostridium obviously correlated (positive negative) homeostasis indexes, behavioral tissue factors, Conclusions regulating microbiota, SCFAs, may potential alleviating diabetes, which provides option treat diabetic impairment.

Language: Английский

Amomum tsao‐ko Attenuates Hyperglycemia and Cognitive Impairment via Regulating Gut Microbiota, SCFAs, and CREB/BDNF/TrkB Signaling Pathway in T2DM Mice DOI
Caixia Wang,

Huilin Ren,

Zhen Wang

et al.

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Background As a medicine‐food fruit, Amomum tsao‐ko has been reported to be beneficial for the management of diabetes. However, its effects and mechanisms in cognitive impairment caused by diabetes remain unclear. This study aimed investigate influences A. on type 2 mellitus (T2DM) mice associated mechanisms. Methods was characterized using UHPLC‐Q‐Orbitrap‐MS/MS. T2DM induced high‐fat diet combined with streptozotocin were treated ethanol extract (EEAT) 8 weeks. The function evaluated Morris water maze (MWM) test, open field test (OFT), novel object recognition (NORT). Hippocampus colon tissues used histopathology, biochemical assays, or protein expression analysis. Additionally, fecal samples subjected 16S rRNA gene sequencing short‐chain fatty acids (SCFAs) detection. Key Results findings demonstrated that EEAT significantly reversed glucose metabolism disorders deficits mice. It promoted CREB/BDNF/TrkB pathway reduced hippocampal inflammatory responses, thereby improving neuronal damage. inhibited loss colonic tight junction proteins, decreased levels factors colon, also reshaped gut microbiota increased SCFAs. Notably, Spearman's correlation analysis indicated Lachnospiraceae NK4A136 group , Ruminococcaceae UCG‐014 Lactobacillus Blautia Lachnoclostridium obviously correlated (positive negative) homeostasis indexes, behavioral tissue factors, Conclusions regulating microbiota, SCFAs, may potential alleviating diabetes, which provides option treat diabetic impairment.

Language: Английский

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