Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101773 - 101773

Published: April 17, 2025

Bone and joint diseases are debilitating conditions that can result in significant functional impairment or even permanent disability. Multiscale metal-based nanocomposites, which integrate hierarchical structures ranging from the nanoscale to macroscale, have emerged as a promising solution this challenge. These materials combine unique properties of nanoparticles (MNPs), such enzyme-like activities, stimuli responsiveness, photothermal conversion, with advanced manufacturing techniques, 3D printing biohybrid systems. The integration MNPs within polymer ceramic matrices offers degree control over mechanical strength, antimicrobial efficacy, manner drug delivery, whilst concomitantly promoting processes osteogenesis chondrogenesis. This review highlights breakthroughs stimulus-responsive (e.g., photo-, magnetically-, pH-activated systems) for on-demand therapy their biocomposite hybrids containing cells extracellular vesicles mimic native tissue microenvironment. applications these composites extensive, bone defects, infections, tumors, degenerative diseases. emphasizes enhanced load-bearing capacity, bioactivity, be achieved through designs. Notwithstanding potential applications, barriers progress persist, including challenges related long-term biocompatibility, regulatory hurdles, scalable manufacturing. Finally, we propose future directions, machine learning-guided design patient-specific biomanufacturing accelerate clinical translation. bridge innovations macroscale functionality, revolutionary force field biomedical engineering, providing personalized regenerative solutions

Language: Английский