Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(4), P. 404 - 404
Published: April 15, 2025
The
increase
in
multidrug-resistant
organisms
worldwide
is
a
major
public
health
threat
driven
by
antibiotic
overuse,
horizontal
gene
transfer
(HGT),
environmental
drivers,
and
deficient
infection
control
hospitals.
In
this
article,
we
discuss
these
factors
summarize
the
new
drugs
treatment
strategies
suggested
to
combat
increasing
challenges
of
(MDR)
bacteria.
New
treatments
recently
developed
involve
targeting
key
processes
involved
bacterial
growth,
such
as
riboswitches
proteolysis,
combination
therapies
improve
efficacy
minimize
adverse
effects.
It
also
tackles
Gram-negative
outer
membrane,
stressing
that
novel
are
needed
evade
permeability
barriers,
efflux
pumps,
resistance
mechanisms.
Other
approaches,
including
phage
therapy,
AMPs,
AI
drug
discovery,
discussed
potential
alternatives.
Finally,
review
points
out
urgency
for
continued
research
development
(R&D),
industry–academic
partnerships,
financial
engines
ensure
MDR
microbes
do
not
exceed
value
antibacterial
therapies.
Sustainability,
Journal Year:
2025,
Volume and Issue:
17(5), P. 2100 - 2100
Published: Feb. 28, 2025
The
extraction
of
metallic
nanoparticles
(MNPs)
from
waste
electrical
and
electronic
equipment
(WEEE)
has
gained
extensive
attention
researchers
for
eco-friendly,
reliable,
sustainable
alternative
protocol
over
the
traditional
linear
economic
approach
(make-use-dispose)
boosting
circular
economy.
A
plethora
MNPs
including
metals/metal
oxide
having
a
size
dimension
ranging
1–100
nanometers
(nm)
have
been
extracted
these
WEEE
by
using
different
chemical,
physical,
biological
methods.
Recovery
certain
precious
can
be
achieved
dismantling
recycling
items
in
form
gold
(Au),
platinum
(Pt),
zinc
(ZnO),
silver
(Ag),
copper
(CuO).
These
provide
huge
range
applications
such
as
antibacterial,
therapeutic,
target
drug
delivery,
biotechnological
applications.
This
comprehensive
review
provides
in-depth
knowledge
synthesis
techniques
delves
into
their
potential
biomedical
fields
with
mechanisms.
article
also
discussed
global
challenges
opportunities
this
area
adopting
concept
economy
to
conserve
natural
resources
future
generations
hence
create
greener
environment
protect
our
planet.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 444 - 444
Published: March 20, 2025
Nanomaterials
represent
an
innovation
in
cancer
imaging
by
offering
enhanced
contrast,
improved
targeting
capabilities,
and
multifunctional
modalities.
Recent
advancements
material
engineering
have
enabled
the
development
of
nanoparticles
tailored
for
various
techniques,
including
magnetic
resonance
(MRI),
computed
tomography
(CT),
positron
emission
(PET),
ultrasound
(US).
These
nanoscale
agents
improve
sensitivity
specificity,
enabling
early
detection
precise
tumor
characterization.
Monte
Carlo
(MC)
simulations
play
a
pivotal
role
optimizing
nanomaterial-based
modeling
their
interactions
with
biological
tissues,
predicting
contrast
enhancement,
refining
dosimetry
radiation-based
techniques.
computational
methods
provide
valuable
insights
into
nanoparticle
behavior,
aiding
design
more
effective
agents.
Moreover,
artificial
intelligence
(AI)
machine
learning
(ML)
approaches
are
transforming
enhancing
image
reconstruction,
automating
segmentation,
improving
diagnostic
accuracy.
AI-driven
models
can
also
optimize
MC-based
accelerating
data
analysis
through
predictive
modeling.
This
review
explores
latest
imaging,
highlighting
synergy
between
nanotechnology,
MC
simulations,
innovations.
By
integrating
these
interdisciplinary
approaches,
future
technologies
achieve
unprecedented
precision,
paving
way
diagnostics
personalized
treatment
strategies.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
Protein‐based
hydrogels
have
been
widely
used
in
the
biomedical
field
since
their
good
biocompatibility
and
adjustable
physical
properties,
which
are
also
similar
to
natural
extracellular
matrix.
However,
fragile
mechanical
properties
single
function
of
protein
limited
application.
Usually,
chemical
modification
proteins
combination
with
other
biological
materials
strategies
improve
performance
hydrogels.
This
review
first
focused
on
method
then
introduced
kinds
protein‐based
detail.
In
addition,
we
summarized
applications
drug
delivery,
wound
dressing,
tissue
engineering,
3D
printing,
biosensors.
Finally,
highlighted
challenges
future
prospects
hydrogels,
may
provide
a
reference
for
design
novel
multifunctional
Journal of Nanotheranostics,
Journal Year:
2025,
Volume and Issue:
6(2), P. 11 - 11
Published: April 9, 2025
Theranostic
nanoparticles
integrate
diagnostic
and
therapeutic
potential,
representing
a
promising
approach
in
precision
medicine.
Accordingly,
numerous
inventions
have
been
patented
to
protect
novel
formulations
methods.
This
review
examines
the
evolution
of
theranostic
nanoparticles,
focusing
on
organic
nanosystems,
particularly
polymeric
lipid
assess
their
development,
technological
advances,
patentability.
A
scoping
was
conducted
following
Preferred
Reporting
Items
for
Systematic
reviews
Meta-Analyses
(PRISMA)
guidelines
World
Intellectual
Property
Organization
(WIPO)
European
Patent
Office
(EPO)
database.
The
search
included
patents
filed
within
last
ten
years
(2014–2024)
that
specifically
claimed
and/or
hybrid
nanoparticles.
Data
extraction
focused
nanoparticle
composition,
synthesis
methods,
functionalization
strategies,
applications.
identified
130
patents,
which
13
met
inclusion
criteria.
These
were
primarily
by
inventors
from
United
States,
Canada,
Great
Britain,
Italy,
China.
Polymeric
frequently
engineered
targeted
drug
delivery
imaging,
utilizing
hyperbranched
polyesters,
sulfated
polymers,
or
chitosan-based
formulations.
Lipid
often
hybridized
with
inorganic
nanomaterials
magnetic
nanostructures
enhance
potential.
While
most
detailed
methods
physicochemical
characterizations,
only
few
provided
comprehensive
preclinical
validation,
limiting
demonstrated
efficacy.
analysis
recent
highlights
significant
advances
design
application
However,
notable
gap
remains
validating
these
nanosystems
clinical
translation.
Future
efforts
should
emphasize
robust
data,
including
vitro
vivo
assessments,
patent
quality
applicability
substantiate
capabilities.
