Novel Antibacterial Approaches and Therapeutic Strategies DOI Creative Commons
Gustavo A. Niño‐Vega, Jorge A. Ortiz-Ramírez, Everardo López-Romero

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 404 - 404

Published: April 15, 2025

The increase in multidrug-resistant organisms worldwide is a major public health threat driven by antibiotic overuse, horizontal gene transfer (HGT), environmental drivers, and deficient infection control hospitals. In this article, we discuss these factors summarize the new drugs treatment strategies suggested to combat increasing challenges of (MDR) bacteria. New treatments recently developed involve targeting key processes involved bacterial growth, such as riboswitches proteolysis, combination therapies improve efficacy minimize adverse effects. It also tackles Gram-negative outer membrane, stressing that novel are needed evade permeability barriers, efflux pumps, resistance mechanisms. Other approaches, including phage therapy, AMPs, AI drug discovery, discussed potential alternatives. Finally, review points out urgency for continued research development (R&D), industry–academic partnerships, financial engines ensure MDR microbes do not exceed value antibacterial therapies.

Language: Английский

Novel Antibacterial Approaches and Therapeutic Strategies DOI Creative Commons
Gustavo A. Niño‐Vega, Jorge A. Ortiz-Ramírez, Everardo López-Romero

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 404 - 404

Published: April 15, 2025

The increase in multidrug-resistant organisms worldwide is a major public health threat driven by antibiotic overuse, horizontal gene transfer (HGT), environmental drivers, and deficient infection control hospitals. In this article, we discuss these factors summarize the new drugs treatment strategies suggested to combat increasing challenges of (MDR) bacteria. New treatments recently developed involve targeting key processes involved bacterial growth, such as riboswitches proteolysis, combination therapies improve efficacy minimize adverse effects. It also tackles Gram-negative outer membrane, stressing that novel are needed evade permeability barriers, efflux pumps, resistance mechanisms. Other approaches, including phage therapy, AMPs, AI drug discovery, discussed potential alternatives. Finally, review points out urgency for continued research development (R&D), industry–academic partnerships, financial engines ensure MDR microbes do not exceed value antibacterial therapies.

Language: Английский

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