Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Children with Obesity: An Obesity Medicine Association (OMA) and Expert Joint Perspective 2025

Obesity Pillars, Journal Year: 2025, Volume and Issue: 14, P. 100164 - 100164

Published: Feb. 1, 2025

This Obesity Medicine Association (OMA) Expert Joint Perspective examines steatotic liver disease (SLD), which is composed of metabolic dysfunction-associated (MASLD), and steatohepatitis (MASH) in children with obesity. The prevalence obesity increasing, rates have tripled since 1963 from 5 % to now 19 US affected 2018. MASLD, the most common seen children, can be a precursor development Type 2 Diabetes (T2DM) primary reason for transplant listing young adults. We must vigilant prevention treatment MASLD childhood prevent further progression. joint clinical perspective based upon scientific evidence, peer expertise. medical literature was reviewed via PubMed search appropriate articles were included this review. work formulated collaboration eight hepatologists/gastroenterologists expertise two physicians OMA. authors who are experts field, determined sentinel questions often asked by clinicians regarding They created consensus guideline on screening, diagnosis, associated children. comorbidity increasing problem that needs addressed urgently. It well known chronic continue these diseases as adults, leads reduced life expectancy, quality life, healthcare financial burden. paper recommend healthy weight reduction not only through lifestyle modification but pharmacotherapy bariatric surgery. Therefore, guidance reviews available therapies achieve reverse progressive fibrosis, disease.

Language: Английский

---

Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 834 - 834

Published: March 14, 2024

Zinc, magnesium, and vitamin K are important nutrients for humans. There various factors that contribute to the development of their deficiency, which might result in or exacerbate diseases. These can also interact with D metabolism activity. This review discusses main aspects zinc, magnesium action body, clinical significance, “crosstalk” D, as well providing general suggestions practice when supplementation these be useful, addition supplementation.

Language: Английский

---

Validation of the 2024 European Association for the Study of Obesity diagnostic criteria: A comprehensive assessment of obesity‐related mortality risks

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Aims Obesity is a global public health challenge, and the traditional WHO‐proposed diagnostic criteria based on body mass index (BMI) often fail to fully assess related risks. The European Association for Study of (EASO) has proposed new that combine BMI, waist‐to‐height ratio (WtHR) complications more accurately evaluate obesity‐related Materials Methods This study utilized data from National Health Nutrition Examination Survey database, covering years 1999–2018. validated EASO diagnosing obesity, defined as BMI ≥25 kg/m 2 , WtHR ≥0.5 presence 12 complications. associations between obesity mortality were assessed using Kaplan–Meier survival curves Cox proportional hazards regression analyses. Mediation analysis was conducted explore potential mechanisms by which impacts patient prognosis. Results A total 39 066 participants included, with mean age 43.6 years; 51.3% male. Over median follow‐up period 141 months, 3708 deaths recorded. prevalence 63.04% according criteria. rate ≥30 only 35.55%. achieved C‐index 0.5549, surpasses predictive accuracy criterion, 0.5265. indicated when criterion diagnose it associated all‐cause cardiovascular disease (CVD)‐related mortality, but did not predict cancer‐related mortality. diagnosed significantly an increased risk (hazard [HR] 95% confidence interval [CI]: 1.13 [1.02, 1.24]), CVD (HR CI: 1.48 [1.20, 1.83]) cancer 1.26 [1.03, 1.54]). When simplified any top five (diabetes mellitus, hypertension, CVD, metabolic syndrome ageing) criteria, had highest (0.612), remained independent prognostic factor poor overall CI mortality: 1.41 [1.26, 1.58], HR 2.08 [1.61, 2.68] 1.32 [1.06, 1.65]). Conclusions confirms value EASO, suggesting these offer accurate assessment

Language: Английский

---

Obesity and micronutrients deficit, when and how to suplement

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Aug. 2, 2024

Since the 1990s worldwide rate of obesity has escalated significantly. This overflow affects all demographic groups, with a notable impact on older adults and women. Obesity is associated variety serious chronic health conditions. Additionally, it linked to endocrine disorders such as hypothyroidism subclinical hypothyroidism. review analyzes connection between micronutrient levels, particularly focusing vitamin D, evaluates potential nutritional supplementation approaches for this population.

Language: Английский

---

Impact of Time-Restricted Eating and High-Intensity Exercise on Nutrient Intake in Women with Overweight/Obesity: Secondary Analysis of a Randomized Controlled Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 218 - 218

Published: Jan. 8, 2025

Inadequate micronutrient intakes are common in individuals with overweight/obesityand can exacerbate cardiovascular and metabolic disease risk. Diet exercise primary strategies for managing overweight may influence nutrient intakes. In this secondary analysis of dietary data collected a randomized controlled trial (RCT, ClinicalTrials.gov (NCT04019860), 15 June 2019) time-restricted eating (TRE), high-intensity interval training (HIIT), combination (TREHIIT), or control group (CON), we investigated intervention effects on energy women overweight/obesity. We 131 (body mass index (BMI) ≥ 27 kg/m2) to 7 weeks TRE (≤10-h daily window ad libitum intake), HIIT (3 sessions/week, performed at ≥90% maximal heart rate), TREHIIT, CON. Participants recorded all intake an online food diary during baseline week (week 0) the end study 6 7). between-group differences changes mean energy, macronutrient, had reduced potassium, magnesium, phosphorus compared CON (p < 0.01). TREHIIT non-significant thiamine, copper, (0.01< p 0.05). alone did not negatively impact induced suboptimal greater number micronutrients A ≤10-h might increase risk inadequacy Future research is needed investigate integrating nutritional guidelines interventions mitigate

Language: Английский

---

Prolonged Hospital Stay in Hypertensive Patients: Retrospective Analysis of Risk Factors and Interactions

Nursing Reports, Journal Year: 2025, Volume and Issue: 15(3), P. 110 - 110

Published: March 19, 2025

Background/Objectives: Arterial hypertension (HT) is a leading modifiable risk factor for cardiovascular diseases, often contributing to prolonged lengths of hospital stay (LOHS), which place significant strain on healthcare systems. This study aimed analyze the factors associated with in patients HT, focusing key biochemical and clinical predictors. Methods: retrospective included 356 adult hospitalized Cardiology Department University Hospital Wroclaw, Poland, between January 2017 June 2021. Data collected demographic characteristics, body mass index (BMI), comorbidities, laboratory parameters. Logistic regression models were used identify predictors LOHS, defined as four or more days, evaluate interactions variables. Results: Lower levels low-density lipoprotein cholesterol (LDL-c) elevated concentrations high-sensitivity C-reactive protein (hsCRP) identified each 1 mg/dL decrease LDL-c increasing odds LOHS by 1.21% (p < 0.001) mg/L increase hsCRP raising 3.80% = 0.004). An interaction sex heart failure (HF) was also observed. Female HF had 3.995-fold higher compared females without 0.001), while no difference found among male 0.890). Conclusions: The HT include lower LDL-c, hsCRP, (HF). Specifically, female demonstrated significantly HF, this relationship not observed patients.

Language: Английский

---

Relationship between composite dietary antioxidants index and growth indicators in children aged 3–12 years: results from two observational studies

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 20, 2025

Background The intake of nutrients with antioxidant properties is closely related to numerous health outcomes. However, the evidence regarding effects nutrient on children's growth indicators still lacking. This study aimed investigate relationship between Composite Dietary Antioxidant Index (CDAI) and child in two cohorts. Methods utilized data from 1,064 participants Children's Cohort Study Micronutrient Deficits Malnutrition (CCSMDM) 2023 database 2,404 National Health Nutrition Examination Survey (NHANES) 2003–2020 for cross-sectional analyses, aged 3–12 years. association CDAI was analyzed using multinomial logistics regression. And we also performed subgroup analyses determine whether there were differences gender explored dose-response by fitting a restricted cubic spline. Results After adjusting potential confounders, positively associated children (height: CCSMDM: OR =1.21, 1.04~1.43, p = 0.017; NHANES: 1.11, 1.04~1.18, 0.001; weight: =1.27, 1.09~1.52, 0.004; 1.12, 1.05~1.19, &lt; 0.001). Our found that significant correlation (vitamin A, vitamin E, zinc, magnesium) height. selenium, magnesium, BMI close contact. Subgroup analysis had higher positive height male children. Conclusions revealed benefits dietary indicators. These results suggested level may help promote It recommended consume combination multiple antioxidants, as their interactions offer benefits. further research needed explore underlying mechanisms synergistic antioxidants development.

Language: Английский

---

Obesity Management in Female Adolescents

Clinical Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

ABSTRACT Background Global childhood obesity continues to rise, particularly in adolescent females. The underlying cause of this change prevalence is multifactorial with a complex interplay genetic, socioeconomic and environmental influences. In review, we aim emphasize the multiple options available for assisting an female improve their overall health longevity. Design Experts from each respective fields reviewed current literature regarding management adolescents. Results Lifestyle changes, including decreases calorie consumption simple carbohydrates as well increases activity/exercise have been mainstay therapy due effects on decreasing insulin resistance associated metabolic disease, weight loss. However, combination provider encouraged loss societal stigma leads increased risk disordered eating. high mental sleep disorders youth are recent findings, importance treating these conditions improved quality life success lifestyle changes. American Academy Pediatrics' 2023 guidelines first across globe recommend early adjunctive use medications obesity. These recommendations correspond development increasing availability new combinations existing mediations glucagon like peptide‐1 receptor agonist class medications. Youth body mass index excess 35−40 kg/m 2 , can now undergo bariatric surgery many countries, very encouraging short‐ medium‐term success. Conclusion There approaches consider when or customized may be needed optimal at individual patient level.

Language: Английский

---

Nutritional Peripheral Neuropathies-Review and Practical Approach

Current Treatment Options in Neurology, Journal Year: 2025, Volume and Issue: 27(1)

Published: May 2, 2025

Language: Английский

---

Association of sociodemographic and lifestyle factors and dietary intake with overweight and obesity among U.S. children: findings from NHANES

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 12, 2024

Childhood overweight/obesity is a serious problem that has not been adequately addressed. As key factor affecting weight gain, the association between dietary intake with childhood overweight and obesity still unclear. The objective of this study was to analyze sociodemographic, lifestyle factors or obesity. We used data from large cross-sectional National Health Nutrition Examination Survey (NHANES). U.S. children aged 6–15 years both were included. For univariate analysis sociodemographic data, t tests performed for continuous variables chi-square discrete variables. Dietary intakes described by median quartile, differences in normal compared rank sum tests. A modern statistical shrinkage technique, LASSO regression examine Our confirms Hispanic ethnicity, increasing age, passive exposure smoking, higher protein intake, caffeine positively associated child Additionally, non-Hispanic White race, physical activity levels, household income, vitamin negatively

Language: Английский

---