Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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The association between obesity indicators and mortality among individuals with hyperlipidemia: evidence from the NHANES 2003–2018

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Obesity is linked to a variety of metabolic issues, with hyperlipidemia being crucial adjustable risk element for cardiovascular diseases (CVD). However, the connection between indicators obesity overall and CVD mortality in American adults remains unknown. This research employed an extensive cohort drawn from National Health Nutrition Examination Survey (NHANES) (2003-2018). Hyperlipidemia was identified through either elevated lipid profiles or self-reported utilization lipid-reducing medications. (weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), body mass (BMI)) were evaluated by physical measurement data. Weighted Cox regression models restricted cubic splines (RCS) assess potential links outcomes. Results further validated subgroup analyses ensure robustness reliability. The receiver operating characteristic (ROC) curve utilized evaluate prognostic capability mortality. study included data 12,785 participants hyperlipidemia. Over average follow-up period 8.4 years, total 1,454 deaths documented, 380 which related heart diseases. analysis manifested that, after adjusting covariates, increased WWI higher likelihood (both P < 0.05). RCS illustrated that BMI WHtR had U-shaped relationships Conversely, linear positive association uncovered > 0.05 nonlinearity). Age, alcohol consumption chronic kidney disease modifying effects on relationship among those area under ROC indicated more effective than predicting deaths. In US hyperlipidemia, BMI, WHtR, followed pattern, whereas correlation has superior predictive prognosis individuals compared WHtR. These findings provide new insights targets health management affected

Language: Английский

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Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management

Language: Английский

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The Perceptions of and Attitudes Toward Obesity in Bulgarian Adults with a BMI ≥ 25.0 kg/m2—An Exploratory Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 373 - 373

Published: Jan. 21, 2025

Background: Obesity affects 33.2% of the adult population in Bulgaria, and there is a scarcity information about affected individuals’ attitudes toward their weight situation. The aim this study was to explore perceptions obesity adults. Methods: present involved questionnaire-based survey that utilized home-based tablet-assisted face-to-face interviews. Interviewees comprised individuals aged 25–64 y/o with BMI > 25.0 kg/m2. Results: Overall, 704 respondents participated (344 overweight; 360 obese). Over 50% participants reported attempts reduce weight, only 6% overweight group 16% obese perceiving condition as worrisome. One-third considered state temporary. main cause for alarm overweight/obese worsening overall physical males an increase clothes size females. need urgent reduction body noted by 12% 40% respondents. reasons being were collated lack activity (noted 52% participants), sedentary lifestyle (51%), stress/depression (41%), excessive consumption carbohydrates (34%), general overconsumption food (33%), poor quality products (28%). Of note, 56% had first consulted medical professional overweight. Most selected dieting without reduction, 48% stating they would try drugs approved reduction. Conclusions: Many have unrealistic self-perception very low motivation take active measures. These discrepancies offer great opportunities better public education structured, strategies.

Language: Английский

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Comparing the association of novel Anthropometric and atherogenicity indices with all-cause, cardiovascular and non-cardiovascular mortality in a general population of Iranian adults

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 100936 - 100936

Published: Jan. 1, 2025

Language: Английский

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Associations Between Body Mass Index (BMI) and Dyslipidemia: Results From the PERSIAN Guilan Cohort Study (PGCS)

Obesity Science & Practice, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 1, 2025

ABSTRACT Background Obesity and dyslipidemia are interconnected complex conditions their prevalence differs across different geographical regions. As a major risk factor for cardiovascular diseases, is often misdiagnosed inadequately treated, highlighting the need region‐specific public health policies. Therefore, objective of this study was to examine associations between BMI in Prospective Epidemiological Research Studies Iran (PERSIAN) Guilan Cohort (PGCS) population. Methods This cross‐sectional analyzed demographic biochemical data from 10,519 participants PGCS Participants were divided into two groups with without compared based on BMI. Data analysis performed SPSS v16 significance level < 0.05. Results The average age 51.52 ± 8.90 years. all equal 75.83%. Among those dyslipidemia, 41.18% 35.39% had overweight obesity, respectively. There positive association (unadjusted OR = 1.09, 95% confidence interval (CI): 1.08–1.10) ( p 0.01), indicating that one‐unit increase participants' BMI, probability having increased by 9%, which remained statistically significant even after adjusting. Analysis components revealed elevated TG cholesterol, as well low HDL levels higher 1.04, 1.01, respectively) 0.01). However, not high LDL 1.01) 0.05). Conclusion Given our studied region its strong prioritizing obesity management decision‐making vital. Greater focus should be given accessing modifying particularly particles, potentially research target prevent mismanagement individuals obesity.

Language: Английский

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Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Background Obesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy safety of bempedoic acid in people with obesity participating CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACL‐Inhibiting Regimen) Outcomes trial. Methods randomized 13 970 patients to daily 180 mg or placebo. Exploratory outcomes including major adverse events‐4 (cardiovascular death, nonfatal myocardial infarction, stroke, coronary revascularization), low‐density lipoprotein cholesterol, hs‐CRP (high‐sensitivity C‐reactive protein), weight change, were assessed over a median 40.7 months 6177 baseline body mass index ≥30 kg/m 2 . Results In obesity, resulted placebo‐corrected reductions cholesterol −22.5% −23.2% at 6 months. treatment reduction 23% (hazard ratio [HR], 0.77 [95% CI, 0.67–0.89]) versus Nonfatal fatal MI reduced by 32% (HR, 0.68 0.53–0.86]), revascularization was 24% 0.76 0.63–0.92]), stroke 36% 0.64 0.45–0.89]) compared At month 36, mean±SD change from −2.3 (6.3) kg for −1.4 (6.1) Adverse events reported 87.4% 86.7% placebo patients. The uric 0.81 (1.26) mg/dL −0.04 (1.05) Conclusions Among events, hs‐CRP, profile consistent previous reports. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02993406.

Language: Английский

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Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 10, 2025

Abstract Obesity is a metabolic disease characterized by an imbalance between caloric intake and expenditure, leading to excess fat increasing the risk of various health conditions. This study compares anti-obesity effects gold nanoparticles (AuNPs) orlistat in experimental model induced obesity Wistar Albino rats. In addition negative positive control rats, obese rats were treated with variable daily weekly doses AuNPs for nine weeks. Bioelectric impedance analysis (BIA) dissection techniques used indirectly directly measure body-composition all rat groups. Hepatic renal function ultrastructure assessed blood biochemical histological examinations detect treatment-related alterations. High reduced body fat, increased muscle mass, improved dyslipidemia, glycemia, antioxidant restored normal TG, FBG, MDA levels reducing obesity-related oxidative damage. Histological ultrastructural showed that these high repaired liver kidney cells, accumulation weight compared standard treatment orlistat.

Language: Английский

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Obesity Management in Primary Care: A Joint Clinical Perspective and Expert Review from the Obesity Medicine Association (OMA) and the American College of Osteopathic Family Physicians (ACOFP) - 2025

Obesity Pillars, Journal Year: 2025, Volume and Issue: unknown, P. 100172 - 100172

Published: March 1, 2025

This collaboration from the Obesity Medicine Association (OMA) and American College of Osteopathic Family Physicians (ACOFP) examines obesity management a primary care perspective. joint perspective is based upon scientific evidence, clinical experience authors, peer review by OMA ACOFP leadership. The goal to identify answer sentinel questions about perspective, utilizing evidence-based publications, guided expert experience. disease that contributes both biomechanical complications most common cardiometabolic abnormalities encountered in care. Barriers impede optimal patients with include failure recognize as disease, lack accurate diagnosis, insufficient access treatment resources, inadequate training, time, adequate reimbursement adverse impact bias, stigma, discrimination. physicians are often first line healthcare setting. affords early intervention opportunities prevent and/or treat overweight obesity. Patient enhanced when clinicians risks benefits anti-obesity medications bariatric procedures, well long-term follow-up. Practical tools regarding 4 pillars nutrition therapy, physical activity, behavior modification, medical interventions (anti-obesity surgery) may assist improve health lives living

Language: Английский

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Joint Association of Remnant Cholesterol and Body Mass Index with Hypertension: A National Cohort Study in Chinese Adults.

PubMed, Journal Year: 2025, Volume and Issue: 18, P. 1813 - 1825

Published: Jan. 1, 2025

Hypertension, a major global health concern, is closely associated with obesity and lipid abnormalities. Remnant cholesterol (RC), triglyceride-rich lipoprotein component, has been linked to cardiovascular diseases, but its joint impact body mass index (BMI) on hypertension risk remains unclear. We analyzed data from 3805 participants (mean age: 57 years; 44.3% male) in the China Health Retirement Longitudinal Study (CHARLS) 2011-2020. Inclusion criteria were adults aged over 45 years complete blood lipids BMI. Participants baseline or missing covariate excluded. Cox proportional hazard models assessed associations, while mediation analysis explored RC's role BMI-hypertension linkage. Over 9-year follow-up, 590 developed hypertension. Obesity (BMI ≥28.0 kg/m²) high RC levels independently (HR: 2.18; 95% CI: 1.48-3.21 for highest tertile). mediated 7.07% of BMI's effect hypertension, BMI 29.3% effect. This study highlights intertwined roles development. Targeting both factors may enhance prevention strategies.

Language: Английский

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