Pregnancy and Infant Outcomes Following SARS-CoV-2 Infection in Pregnancy during Delta Variant Predominance – Surveillance for Emerging Threats to Pregnant People and Infants

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 28, 2023

Abstract Background : SARS-CoV-2 infection in pregnancy is associated with an increased risk of adverse birth outcomes, such as preterm birth, stillbirth, and maternal infant complications. Prior research suggests severe COVID-19 illness stillbirth pregnant people during the Delta variant predominance 2021; however, those studies did not assess timing pregnancy, few described vaccination status. Objective Using a large population-based cohort, this study compared outcomes demographic clinical characteristics prior to period. Study Design This retrospective cohort analysis included persons confirmed from six U.S. jurisdictions reporting Surveillance for Emerging Threats Pregnant People Infants Network (SET-NET). Data were collected through case reports polymerase chain reaction (PCR) positive linkages certificates, fetal death records, immunization records obtain We frequency spontaneous abortion (<20 weeksgestation), (≥20 weeks), (<37 small gestational age, term NICU admission between time periods pre-Delta predominance. determined by when variants constituted more than 50% sequences isolated according regional genomic surveillance data, defined (March 3, 2020-June 25, 2021) (June 26-December 2021). Adjusted prevalence ratios (aPR) estimated each outcome measure using Poisson regression adjusted continuous race/ethnicity, insurance status at delivery. Results Among 57,529 57,171 (99.4%) liveborn infants, 56 (0.1%) abortions, 302 (0.5%) stillbirths. Most unvaccinated infection, highest proportion (78.5%). Of infections who previously vaccinated, last was median 183 days. Compared pre-Delta, higher stillbirths (0.7% versus 0.4%, aPR 1.57, 95% CI: 1.15, 2.14) births (12.8%versus 11.9%, 1.14, 1.07, 1.21). The period lower (aPR 0.72 95%, 0.64, 0.79) pre-Delta. During period, third trimester first andsecond combined 1.42, 1.29,1.57). Conclusion In U.S.-based majority unvaccinated, frequencies among occurring earlier pregnancy. These findings confirm risks on specifically presence presentation.

Language: Английский

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mRNA-Covid-vaccins en borstvoeding: twijfel over de veiligheid is ongegrond

Tijdschrift voor Geneeskunde, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 30, 2023

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