Bioinformatics and systems biology approaches to identify the effects of COVID-19 on neurodegenerative diseases: A review DOI Creative Commons
Fan Bu, Ruiqian Guan, Wanyu Wang

et al.

Medicine, Journal Year: 2022, Volume and Issue: 101(49), P. e32100 - e32100

Published: Dec. 9, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing disease (COVID-19), has been devastated by COVID-19 in an increasing number of countries and health care systems around the world since its announcement a global pandemic on 11 March 2020. During pandemic, emerging novel viral mutant variants have caused multiple outbreaks are prone to genetic evolution, serious damage human health. As confirmed cases spread rapidly, there is evidence that SARS-CoV-2 infection involves central nervous system (CNS) peripheral (PNS), directly or indirectly damaging neurons further leading neurodegenerative diseases (ND), but molecular mechanisms ND CVOID-19 unknown. We employed transcriptomic profiling detect several major ND: Alzheimer 's (AD), Parkinson' s (PD), sclerosis (MS) common pathways biomarkers association with COVID-19, helping understand link between COVID-19. There were 14, 30 19 differentially expressed genes (DEGs) (PD) (MS), respectively; enrichment analysis showed MAPK, IL-17, PI3K-Akt other signaling significantly expressed; hub (HGs) DEGs CRH, SST, TAC1, SLC32A1, GAD2, GAD1, VIP SYP. Analysis transcriptome data suggests co-morbid AD, PD, MS, providing new ideas therapeutic strategies for clinical prevention treatment ND.

Language: Английский

Bioinformatics and systems biology approaches to identify the effects of COVID-19 on neurodegenerative diseases: A review DOI Creative Commons
Fan Bu, Ruiqian Guan, Wanyu Wang

et al.

Medicine, Journal Year: 2022, Volume and Issue: 101(49), P. e32100 - e32100

Published: Dec. 9, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing disease (COVID-19), has been devastated by COVID-19 in an increasing number of countries and health care systems around the world since its announcement a global pandemic on 11 March 2020. During pandemic, emerging novel viral mutant variants have caused multiple outbreaks are prone to genetic evolution, serious damage human health. As confirmed cases spread rapidly, there is evidence that SARS-CoV-2 infection involves central nervous system (CNS) peripheral (PNS), directly or indirectly damaging neurons further leading neurodegenerative diseases (ND), but molecular mechanisms ND CVOID-19 unknown. We employed transcriptomic profiling detect several major ND: Alzheimer 's (AD), Parkinson' s (PD), sclerosis (MS) common pathways biomarkers association with COVID-19, helping understand link between COVID-19. There were 14, 30 19 differentially expressed genes (DEGs) (PD) (MS), respectively; enrichment analysis showed MAPK, IL-17, PI3K-Akt other signaling significantly expressed; hub (HGs) DEGs CRH, SST, TAC1, SLC32A1, GAD2, GAD1, VIP SYP. Analysis transcriptome data suggests co-morbid AD, PD, MS, providing new ideas therapeutic strategies for clinical prevention treatment ND.

Language: Английский

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