mSphere, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
ABSTRACT Recent advancements in synthetic biology and sequencing technologies have revolutionized the ability to manipulate viral genomes with unparalleled precision. This review focuses on two powerful methodologies: deep mutational scanning CRISPR-based genome editing, that enable comprehensive mutagenesis detailed functional characterization of proteins. These approaches significantly deepened our understanding molecular determinants driving evolution adaptation. Furthermore, we discuss how these advances provide transformative insights for future vaccine development therapeutic strategies.
Language: Английский