Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research, Journal Year: 2021, Volume and Issue: 16(1)

Published: Oct. 7, 2021

Abstract Background Osteosarcoma is the most prevalent malignant osseous sarcoma in children and adolescents, whose prognosis still relatively poor nowadays. Recent studies have shown critical function potential clinical applications of circular RNAs (circRNAs) osteosarcoma. Our review aimed to perform an updated meta-analysis explore their clinicopathologic significance prognostic value. Methods The structured literature was conducted via eight electronic databases four gray sources until 20 Feb 2021 identify eligible studies. data extracted directly from articles or reconstructed based on Kaplan-Meier curves. Newcastle-Ottawa Scale (NOS) tool used assess study quality. circRNAs measured through odds ratios (ORs) 95% confidence intervals (CIs), while value evaluated hazard (HRs) CIs overall survival (OS) disease-free (DFS). Heterogeneity publication bias were assessed. Sensitivity analyses conducted. Subgroup performed according characteristics. An additional analysis investigate relation between circ_0002052 Results Fifty-two identified, which 38 features 36 included quantitative analysis. quality moderate with a median NOS score 5.5 stars (range 3 8). For features, dysregulated related larger tumor size (OR 2.122, 95%CI 1.418–3.175), advanced stage 2.847, 2.059–3.935), present metastasis 2.630, 1.583–4.371). chemotherapy, suggest better response 0.443, 0.231–0.849), but higher probability resistance 9.343, 5.352–16.309). prognosis, significantly correlated OS (HR 2.437, 2.224–2.670) DFS 2.125, 1.621–2.786). results did not show differences among subgroups. Higher expression showed 3.197, 2.054–4.976). Conclusions demonstrated that abnormally expressed response, osteosarcoma patients. However, more are encouraged provide robust evidence translate into practice. Trial registration PROSPERO ID: CRD42021235031

Language: Английский

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Roles of long non-coding RNA in prostate cancer pathogenesis

Clinical Genitourinary Cancer, Journal Year: 2024, Volume and Issue: 22(6), P. 102213 - 102213

Published: Aug. 28, 2024

Language: Английский

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Mahanimbine Attenuates Ovariectomy-Induced Osteoporosis in Rats by Regulating Bone Turnover Markers and SIRT1-NF-κB Pathway

Revista Brasileira de Farmacognosia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Language: Английский

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Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis

BMC Genomics, Journal Year: 2022, Volume and Issue: 23(1)

Published: Nov. 24, 2022

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis. As a potential zoonotic pathogen, MAP also seriously threatens human health and social security. At present, long non-coding RNA (lncRNA) has attracted wide attention as an useful biomarker in various diseases. Therefore, our study analyzed lncRNA expression profiles lncRNA-mRNA regulatory network infected bovine monocytes-macrophages uninfected cells by high-throughput sequencing. A total 4641 differentially expressed lncRNAs genes were identified, including 3111 up-regulated 1530 down-regulated genes. In addition, interaction analysis was performed to predict target lncRNA. Among them, after infection, 86 targeted mRNA, which only 6 significantly different. The results Gene Ontology (GO) enrichment showed that enriched functional groups related immune regulation. Multiple signal pathways NF-κB, NOD-like receptor, Cytokine-cytokine Toll-like receptor signaling pathway, Chemokine other important biochemical, metabolic transduction Kyoto Encyclopedia Genes Genomes (KEGG). this study, macrophage transcriptomes response infection expected provide key information deeply understand role pathogen initiating inappropriate persistent susceptible hosts molecular mechanisms might underlie early phases

Language: Английский

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The genetic and epigenetic contributions to the development of nutritional rickets

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 22, 2022

Nutritional rickets is an important disease in global health. Although nutritional commonly manifests as bony deformities, there increased risk of life-threatening seizures secondary to hypocalcaemia. Dietary vitamin D deficiency associated with the development among children and infants. This especially true populations darker skinned individuals high-latitude environments due decreased ultraviolet light exposure, tropical subtropical climates cultural practices. A growing body evidence has demonstrated that genetic factors might influence likelihood developing by influencing individual’s susceptibility develop deficiencies and/or calcium. been drawn from a variety different techniques ranging traditional twin studies next generation sequencing techniques. Additionally, role epigenome rickets, although poorly understood, may be related effects DNA methylation non-coding RNAs on genes involved bone metabolism. review aims provide overview current investigates epigenetic determinants rickets.

Language: Английский

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