iScience,
Journal Year:
2023,
Volume and Issue:
26(9), P. 107556 - 107556
Published: Aug. 7, 2023
The
focus
of
the
study
is
to
examine
function
TYMSOS
in
immune
escape
breast
cancer,
which
most
frequently
diagnosed
malignancy
among
women
globally.
Our
demonstrated
that
upregulated
was
associated
with
unfavorable
prognosis
and
cancer.
promoted
malignant
phenotypes
cancer
cells,
reduced
cytotoxicity
NK92
cells
on
these
cells.
CBX3
a
downstream
effector
TYMSOS-induced
Mechanistic
studies
showed
facilitated
CBX3-mediated
transcriptional
repression
ULBP3,
it
also
SYVN1-mediated
ubiquitin-proteasomal
degradation
ULBP3.
cell
growth,
metastasis,
via
CBX3/ULBP3
or
SYVN1/ULBP3
axis.
vivo
further
silencing
repressed
tumor
growth
boosted
NK
cytotoxicity.
In
sum,
metastasis
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Abstract
Long
noncoding
RNAs
(lncRNAs)
play
critical
roles
in
the
initiation
and
progression
of
breast
cancer.
However,
specific
mechanisms
biological
functions
lncRNAs
cancer
remain
incompletely
understood.
Bioinformatics
analysis
identifies
a
novel
lncRNA,
CD2BP2‐DT,
that
is
overexpressed
correlates
with
adverse
clinicopathological
features
poor
overall
survival.
Both
vivo
vitro
experiments
demonstrate
CD2BP2‐DT
promotes
proliferation
cells.
Mechanistically,
NAT10
mediates
N4‐acetylcytidine
(ac4C)
modification
enhancing
its
RNA
stability
expression.
More
importantly,
enhances
CDK1
mRNA
by
mediating
YBX1
phase
separation,
thereby
promoting
In
conclusion,
lncRNA
identified
as
crucial
driver
cell
through
YBX1/CDK1
axis,
highlighting
potential
promising
biomarker
therapeutic
target
for
Diseases,
Journal Year:
2025,
Volume and Issue:
13(3), P. 86 - 86
Published: March 17, 2025
Background:
Breast
cancer
(BC)
is
the
most
common
among
women
worldwide,
with
incidence
and
mortality
rates
varying
across
ethnic
groups
due
to
sociodemographic,
clinicopathological,
genomic
differences.
This
study
aimed
characterize
landscape
of
BC
in
diverse
using
computational
tools
explore
these
variations.
Methodology:
cBioPortal
was
used
analyze
genomic,
sociodemographic
data
from
1084
samples.
Mutated
genes
were
classified
based
on
GeneCards
platform
data.
Enrichment
analysis
performed
CancerHallmarks,
not
found
compared
MSigDB’s
Hallmark
Gene
Sets.
Genes
absent
both
further
analyzed
NDEx
through
Cytoscape.org
their
role
cancer.
Results:
Significant
differences
(p
<
0.05)
observed
sex,
tumor
subtypes,
genetic
ancestry,
median
fraction
altered
genome,
mutation
count,
frequencies
groups.
We
identified
frequently
mutated
genes.
Some
be
associated
classic
hallmarks,
such
as
replicative
immortality,
sustained
proliferative
signaling,
evasion
growth
suppressors.
However,
exact
some
remains
unclear,
highlighting
need
for
research
better
understand
involvement
biology.
Conclusions:
significant
clinicopathological
variations
While
key
hallmarks
found,
incomplete
characterization
highlights
research,
especially
focusing
groups,
biology
improve
personalized
treatments.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(4)
Published: April 1, 2025
Abstract
Exosomes,
as
mediators
of
intercellular
communication,
can
be
released
from
different
types
cells
and
regulate
the
function
target
cell
by
transferring
cargo,
such
proteins,
DNA,
RNA.
Recent
investigations
have
revealed
a
preponderance
long
noncoding
RNAs
(lncRNAs),
subclass
RNAs,
within
exosomes,
where
they
exhibit
notable
stability
are
implicated
in
development
progression
neoplastic
processes,
tumor
angiogenesis.
Angiogenesis,
hallmark
cancer,
provides
diffusible
nutrients
oxygen
to
distant
guarantees
tumorigenesis
metastasis.
Exosomal
lncRNAs,
including
MALAT1,
OIP5‐AS1,
PART1,
SNHG
family,
FAM225A,
ATB,
RAMP2‐AS1,
UCA1,
TRPM2‐AS,
FGD5‐AS1,
LINC0016,
could
modulate
angiogenesis
activating
signaling
cascades
cells,
microRNAs
(miRNAs).
Regulation
through
modulation
exosomal
lncRNAs
reliable
strategy
for
cancer
therapy.
In
this
review,
we
discuss
characteristics
biogenesis
exosomes
how
involved
various
processes
tumorigenesis.
Our
primary
focus
is
on
their
impact
angiogenesis,
potential
novel
diagnostic
markers
therapeutic
targets
cancers.
Molecular Therapy,
Journal Year:
2023,
Volume and Issue:
31(6), P. 1577 - 1595
Published: May 10, 2023
Next-generation
sequencing
has
revealed
that
less
than
2%
of
transcribed
genes
are
translated
into
proteins,
with
a
large
portion
noncoding
RNAs
(ncRNAs).
Among
these,
long
(lncRNAs)
represent
the
largest
group
and
pervasively
throughout
genome.
Dysfunctions
in
lncRNAs
have
been
found
various
diseases,
highlighting
their
potential
as
therapeutic,
diagnostic,
prognostic
targets.
However,
challenges,
such
unknown
molecular
mechanisms
nonspecific
immune
responses,
issues
drug
specificity
delivery
present
obstacles
translating
clinical
applications.
In
this
review,
we
summarize
recent
publications
explored
lncRNA
functions
human
diseases.
We
also
discuss
challenges
future
directions
for
developing
treatments,
aiming
to
bridge
gap
between
functional
studies
inspire
further
exploration
field.
iScience,
Journal Year:
2023,
Volume and Issue:
26(9), P. 107556 - 107556
Published: Aug. 7, 2023
The
focus
of
the
study
is
to
examine
function
TYMSOS
in
immune
escape
breast
cancer,
which
most
frequently
diagnosed
malignancy
among
women
globally.
Our
demonstrated
that
upregulated
was
associated
with
unfavorable
prognosis
and
cancer.
promoted
malignant
phenotypes
cancer
cells,
reduced
cytotoxicity
NK92
cells
on
these
cells.
CBX3
a
downstream
effector
TYMSOS-induced
Mechanistic
studies
showed
facilitated
CBX3-mediated
transcriptional
repression
ULBP3,
it
also
SYVN1-mediated
ubiquitin-proteasomal
degradation
ULBP3.
cell
growth,
metastasis,
via
CBX3/ULBP3
or
SYVN1/ULBP3
axis.
vivo
further
silencing
repressed
tumor
growth
boosted
NK
cytotoxicity.
In
sum,
metastasis
