Ferroptosis in Cancer Progression: Role of Noncoding RNAs

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(5), P. 1829 - 1843

Published: Jan. 1, 2022

Ferroptosis is a novel form of programmed cell death, and it characterized by iron-dependent oxidative damage, lipid peroxidation reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence abundant cells can inhibit progression. Recently, some noncoding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular been shown to be involved biological processes ferroptosis, thus affecting cancer growth. However, the definite regulatory mechanism this phenomenon still unclear. To clarify issue, increasing focused on ncRNAs initiation development role progression various cancers, such as lung, liver, breast cancers. In review, we systematically summarized relationship between ferroptosis-associated Moreover, additional evidence needed identify ferroptosis-related This review will help us understand may provide new ideas for exploring diagnostic therapeutic biomarkers future.

Language: Английский

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Long non-coding RNA mediated drug resistance in breast cancer

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 63, P. 100851 - 100851

Published: July 1, 2022

Language: Английский

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Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

Functional & Integrative Genomics, Journal Year: 2023, Volume and Issue: 23(1)

Published: Jan. 10, 2023

Language: Английский

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The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 14, 2022

Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts are known for their inability to encode proteins. NcRNAs consist a diverse range RNA species, including long non-coding (lncRNAs), have significant meaning epigenetic modification, post-transcriptional regulation target genes, molecular interference, etc. The dysregulation ncRNAs will mediate pathogenesis diseases, like cancer. Pancreatic cancer, as one most lethal malignancies in digestive system that is hard make definite diagnosis at an early clinicopathological stage with miserable prognosis. Therefore, identification potential and clinically applicable biomarker momentous improve overall survival rate positively ameliorate prognosis patients pancreatic carcinoma. LncRNAs kind exert multitudinous biological functions, act sponges, relying on microRNA response elements (MREs) competitively microRNAs (miRNAs), thereby attenuating degradation or inhibition miRNAs own downstream protein-coding also thus regulating initiation progression neoplasms. LncRNAs, emerge aforementioned function called competing endogenous (ceRNAs). Consequently, abundant research lncRNAs biomarkers critical significance diagnosis, targeted therapy, well monitoring

Language: Английский

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Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Aug. 17, 2022

Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a serious, long-term threat to patients’ health and life. Systemic chemotherapy remains first-line therapeutic approach for recurrent or metastatic cancer patients after surgery, with potential effectively extend patient survival. However, development drug resistance seriously limits clinical efficiency ultimately results in treatment failure death. A large number studies have shown that non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular are widely involved regulation resistance. Their dysregulation contributes by modulating expression specific target genes cellular apoptosis, autophagy, efflux, epithelial-to-mesenchymal transition (EMT), stem cells (CSCs). Moreover, some ncRNAs also possess great as efficient, biomarkers diagnosis prognosis well targets patients. In this review, we summarize recent findings on emerging role underlying mechanisms focus their applications treatment. This information will be benefit early prognostic assessments ncRNA-based strategies

Language: Английский

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Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 245, P. 154438 - 154438

Published: April 6, 2023

Language: Английский

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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 101(5), P. 501 - 526

Published: April 4, 2023

Language: Английский

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Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 246, P. 154512 - 154512

Published: May 9, 2023

Language: Английский

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Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 8, 2023

Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth, and early metastasis. The clinical outcomes of LC patients are generally poor due to the insufficient elucidation pathological mechanisms, low efficiency detection assessment methods, lack individualized therapeutic strategies. Non-coding RNAs (ncRNAs), including microRNA (miRNA), long non-coding RNA (lncRNA), circular (circRNA), endogenous regulators that widely involved in modulation almost all aspects life activities, from organogenesis aging immunity cancer. They commonly play vital roles various biological processes by regulating gene expression via their interactions DNA, RNA, or protein. An increasing amount studies have demonstrated ncRNAs closely correlated initiation development LC. Their dysregulation promotes progression distinct such as influencing protein activity, activating oncogenic signaling pathways, altering specific expression. Furthermore, some present certain values biomarker candidates targets for patients. A complete understanding mechanisms may be highly beneficial developing ncRNA-based therapeutics This review mainly focuses on intricate miRNA, lncRNA, circRNA discuss underlying applications treatment.

Language: Английский

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Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 28, 2022

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin (ADR), vincristine (VCR), paclitaxel (PTX), platinum drugs, remains one fundamental methods GC treatment has efficiently improved patients' prognosis. However, most patients eventually develop resistance to chemotherapeutic agents, failure clinical death. Recent studies suggest that long non-coding RNAs (lncRNAs) are involved in drug by modulating expression resistance-related genes via sponging microRNAs (miRNAs). Moreover, lncRNAs also play crucial roles a variety mechanisms, such as regulation oncogenic signaling pathways, inhibition apoptosis, induction autophagy, modulation stem cells (CSCs), promotion epithelial-to-mesenchymal transition (EMT) process. Some exhibit great potential diagnostic prognostic biomarkers, well therapeutic targets for patients. Therefore, understanding role their mechanisms may provide us novel insights developing strategies individual diagnosis therapy. In this review, we summarize recent findings on underlying regulated lncRNAs. We discuss applications biomarkers GC.

Language: Английский

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