Multiparticulate Drug Delivery of Losartan Potassium via Extrusion-Spheronization: Formulation and Dissolution Comparisons

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Background: Losartan potassium, an antihypertensive medication, has high solubility and a short half-life that result in potential adverse effects rapid drug clearance. Multiparticulate delivery systems enhance the drug’s bioavailability, decrease patient-to-patient variability, optimize distribution. Herein, losartan potassium pellets for sustained release were developed characterized. Methods: The formulation process involved varying concentrations of Eudragit RSPO (200 mg, 400 or 600 mg) L100 across nine pellet batches, adjusting triethyl citrate accordingly. pellets’ bulk density, tapped flow properties (Carr’s index, Hausner’s ratio, angle repose), content, particle size distribution, vitro evaluated. Interactions between excipients analyzed with FTIR DSC. Results: spectra indicated physical interactions without major chemical alterations, whereas DSC thermograms revealed changes thermal behavior due to excipient interactions. In studies formulations higher achieved controlled, prolonged release. optimized batch (F7) demonstrated balanced characteristics including favorable good properties, profile. Varying polymer plasticizer significantly influenced performance, F7 was found be most promising sustained-release applications. Conclusion: This study underscores importance selection optimization developing effective systems, implications enhancing therapeutic outcomes clinical practice.

Language: Английский

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Solubility enhancement of meloxicam by phospholipid complexation

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(1), P. 91 - 95

Published: Jan. 15, 2024

The best solubility enhancement approach is phospholipids complexation. It has been effectively employed by a number of writers to enhance the permeability, oral bioavailability, and several medicinal substances. meloxicam member BCS Class II, because its poor high clinical application may have constrained. Therefore, it necessary use method that modifies biopharmaceutical features. In this work, meloxicam, an NSAID with demonstrated anticancer action, was combined phospholipid increase solubility. Utilizing solvent evaporation, complex produced. Particle size, zeta potential, SEM analysis, in vitro drug release, were assessed for produced complex. results obtained study showed smaller particle size nanometer range physical stability desired potential. Meloxicam's prolonged release from investigation. apparent analysis Pure drug's times higher than pure form. Hence conclusion we can say complexation could be ideal like meloxicam. Keyword: Meloxicam, complex, solubility,

Language: Английский

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Quality By Design in Quality Assurance

Published: Jan. 1, 2024

Juran introduced the concept of quality by design (QbD) initially, who held view that ought to be scheduled and believed majority crises issues stem form how was initially planned. New processes can explored learning about current processes, improve performance these globally competitive, experimental is a potent technique instrument for QbD. A crucial component contemporary approach design. When it comes proper vocabulary element design, professional experts from industries are often confused. The goal assurance (QA), part management, give customers certainty their needs will addressed. This chapter briefly examines procedures cycles QA in many industries, along with all tools, benefits, regulatory aspects relationship between QbD as well difficulties getting industry embrace also covered. It may concluded essential parts management system (QMS), has been discovered modern method achieving predetermined objectives.

Language: Английский

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Formulation and Evaluation of Nicotinamide Microsponges – The First Step Towards the Development of a Novel Topical Dosage Form

International Journal of Pharmaceutical Sciences and Drug Research, Journal Year: 2024, Volume and Issue: unknown, P. 546 - 556

Published: July 30, 2024

The objective of this work was to formulate and analyze microsponges nicotinamide. said formulation created using the emulsion solvent diffusion technique, a 3 level two factor-based factorial design applied optimize effect stabilizer (X1), as well drug (X2), amounts on entrapment efficiency (Y1) average particle size (Y2). Various parameters, such flow characteristics, percentage yield, concentration, in-vitro release tests, efficiency, scanning electron microscopy (SEM), were evaluated. All parameters found be within acceptable range. Design Expert 13 employed microsponges, optimal batch determined by examining desirability data. From analysis, 302.87 59.71 mg, respectively. reliability preparation evaluation optimized confirmed less than 5% discrepancy between observed predicted values parameters. SEM images revealed that prepared with uniform spherical morphology. study concluded nicotinamide successfully Further steps will involve incorporating into novel topical dosage form.

Language: Английский

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Nanotechnology based delivery of nutraceuticals

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 34

Published: Jan. 1, 2023

Language: Английский

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