Published: Dec. 6, 2024
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 2030 - 2030
Published: May 27, 2024
Immunotherapy is a rapidly advancing field of research in the treatment conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, inorganic NPs, discuss their detailed design intricacies, mechanisms, applications, current regulatory issues. This type nanomaterial targeting specific cells or tissues controlling release kinetics could push technological frontiers provide new innovative solutions immune-related disorders diseases without off-target effects. These materials enable interactions cells, thereby enhancing effectiveness checkpoint inhibitors, vaccines, adoptive cell therapies. Moreover, they allow fine-tuning responses while minimizing side At intersection nanotechnology immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy reshape disease management. By prioritizing safety, customization, compliance standards, these systems make significant contributions precision medicine, significantly impacting healthcare landscape.
Language: Английский
Citations
5
Semiconductors, Journal Year: 2025, Volume and Issue: 59(1), P. 77 - 90
Published: Jan. 1, 2025
Language: Английский
Citations
0
Published: March 10, 2025
Review Quantification of Nanomaterial Surfaces Harshit Kumar and Mingdi Yan * Department Chemistry, University Massachusetts Lowell, 1 Avenue, MA 01854, USA Correspondence: [email protected] Received: 24 February 2025; Revised: 3 March Accepted: 5 Published: 10 2025 Abstract: nanomaterial surfaces is critical in the design nanomaterials with predictable tailored functions. Nanomaterials exhibit unique surface properties, such as high surface-to-volume ratios tunable chemistry, which govern their stability, reactivity, functions a wide range applications including catalysis, drug delivery, bioimaging, environmental remediation. However, quantitative analysis challenging due to inherent heterogeneity, affects structure, ligand density presentation. This mini review discusses several important aspects quantification, density, functional groups, reactions. Traditional analytical methods, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), UV-vis well emerging techniques that offer higher spatial resolution sensitivity are discussed, examples given.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.
Language: Английский
Citations
0
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: March 13, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1316 - 1316
Published: March 14, 2025
The effectiveness of iron oxide nanoparticles in enhancing crop plant development depends on their stabilization. In this study, the effect hyaluronic acid (HA), used both as a stabilizer for (HA-MNP) and independently, was evaluated maize seedlings. Different concentrations HA-MNP (0.625–7.5 mg/L) were tested alongside 0.01% HA solution. Growth parameters, antioxidant enzyme activities (peroxidase polyphenol oxidase), photosynthetic pigments (chlorophyll carotenoids), phenolic content, genotoxicity analyzed. While alone led to slight decreases seedling length, pigment levels compared control, it increased peroxidase activity mitotic index. Lower (below 2.5 enhanced growth, likely due improved uptake, whereas higher reduced content. All induced genotoxic effects, which proven by an index chromosomal aberrations, indicating positive defensive responses oxidative stress. These findings suggest complex interaction between HA, HA-MNP, seedlings, where play significant role modulating growth stress response, while may induce toxicity.
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 108 - 108
Published: March 19, 2025
Loss of implant function is a common complication in orthopaedic and dental surgery. Among the primary causes failure are peri-implant infections which often result removal. This study demonstrates development new antimicrobial titanium coating with ZnO nanoparticles various sizes morphologies immobilised poly(allylamine hydrochloride) alginate multilayers, combined epitaxially grown vaterite crystals. The coated samples were characterised methods (FTIR, XRD, SEM) surface properties evaluated via water contact angle charge measurements. Zinc ion release was quantified using ICP-MS. efficacy coatings tested against Staphylococcus aureus, epidermidis, Candida albicans while biocompatibility preosteoblast cells (MC3T3-E1). Results demonstrated successful preparation calcium carbonate/ZnO composite on surfaces. Zn ions released from dramatically influenced morphology where flower-like observed. surfaces exhibited robust activity, achieving over 90% microbial viability reduction for albicans. Importantly, Zn2+ concentrations remained below cytotoxicity limit MC3T3-E1 cells, showing potential safe effective applications.
Language: Английский
Citations
0
Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Despite advancements made in treatment options, cancer continues to be one of the leading causes death worldwide. Photodynamic therapy (PDT) has gained attention as a minimally invasive and highly selective option for cancer. However, challenges due hydrophobicity photosensitizers their poor tumor selectivity have limited use therapy. Recent developments nanotechnology, particularly gold nanoparticles (AuNPs), help overcome these challenges. AuNPs provide stable biocompatible platform deliver photosensitizers, improving solubility, stability, ability target tumors while reducing side effects. Functionalized take advantage mechanisms like enhanced permeability retention (EPR) effect active targeting, reactive oxygen species (ROS) production overall therapeutic efficacy. This review explores innovations AuNP-based PDT systems, including ligand-functionalized nanoparticles, bioresponsive coatings, theranostic approaches that combine imaging with By delving into important aspects synthesis, characterization, functionalization, we show how improve delivery performance photosensitizers. For instance, systems functionalized prostate-specific membrane antigen (PSMA) shown increased precision efficacy vivo. These are paving way more targeted safer treatments, establishing promising approach developing effective oncological therapies greater fewer
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100658 - 100658
Published: April 18, 2025
Language: Английский
Citations
0