ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(40)
Published: Oct. 1, 2024
Abstract
Lung
cancer
has
become
the
leading
cause
of
cancer‐related
deaths,
surpassing
all
other
forms
cancer.
Among
lung
cancers,
non‐small
cell
(NSCLC)
accounts
for
approximately
85%
cases.
The
use
tobacco,
genetic
traits,
and
radiation
exposure
are
amongst
major
reasons
ongoing
research
in
medical
field
considered
efficacy
nanocarriers
targeting
various
cells.
several
biomaterials,
lipid‐based
have
gained
special
attention
due
to
their
excellent
compatibility,
improved
efficacy,
encapsulation
ability
diverse
therapeutic
agents.
Phospholipids
naturally
occurring
amphiphilic
moieties
found
living
creatures.
presence
phospholipids
biomembrane
aids
permeability
phospholipid‐based
drug
carrier.
It
can
also
facilitate
agents
microenvironment
without
degrading
encapsulated
drug.
be
employed
develop
conjugated
vesicular
nanoformulation
that
result
prolonged
circulatory
half‐life
controlled
release
drugs.
suitable
biomaterials
attach
a
ligand
tissue‐specific
targeting.
Recent
researches
reported
effective
chemotherapeutic
agents,
genes,
vaccines
through
This
review
focuses
on
rationality
applications
therapy.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117372 - 117372
Published: Aug. 28, 2024
Polymeric
nanoparticles
have
emerged
as
promising
contenders
for
addressing
the
intricate
challenges
encountered
in
brain
tumor
therapy
due
to
their
distinctive
attributes,
including
adjustable
size,
biocompatibility,
and
controlled
drug
release
kinetics.
This
review
comprehensively
delves
into
latest
developments
synthesizing,
characterizing,
applying
polymeric
explicitly
tailored
therapy.
Various
synthesis
methodologies,
such
emulsion
polymerization,
nanoprecipitation,
template-assisted
fabrication,
are
scrutinized
within
context
of
targeting,
elucidating
advantages
limitations
concerning
traversing
blood-brain
barrier.
Furthermore,
strategies
pertaining
surface
modification
functionalization
expounded
upon
augment
stability,
targeting
prowess
amidst
milieu
microenvironment.
Characterization
techniques
encompassing
dynamic
light
scattering,
transmission
electron
microscopy,
spectroscopic
methods
evaluate
physicochemical
attributes
engineered
Moreover,
a
comprehensive
exploration
manifold
applications
delivery,
gene
therapy,
imaging,
combination
therapies
tumours
is
undertaken.
Special
emphasis
placed
on
encapsulation
diverse
therapeutics
nanoparticles,
thereby
shielding
them
from
degradation
enabling
precise
brain.
Additionally,
recent
advancements
stimuli-responsive
multifunctional
probed
potential
personalized
medicine
theranostics
tumours.
In
essence,
this
furnishes
an
all-encompassing
overview
strides
made
tailoring
illuminating
synthesis,
characterization,
multifaceted
application.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13302 - 13302
Published: Dec. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 7, 2025
Obesity
is
a
major
global
health
challenge,
contributing
to
metabolic
disorders
such
as
type
2
diabetes,
cardiovascular
diseases,
and
hypertension.
The
increasing
prevalence
of
obesity,
driven
by
sedentary
lifestyles,
poor
dietary
habits,
genetic
predisposition,
underscores
the
urgent
need
for
effective
therapeutic
strategies.
Conventional
pharmacological
treatments,
including
appetite
suppressants
modulators,
often
fail
provide
sustainable
weight
loss
due
side
effects,
adherence,
limited
long-term
efficacy.
As
result,
natural
bioactive
compounds
have
gained
attention
their
anti-obesity
potential.
However,
clinical
application
hindered
bioavailability,
rapid
metabolism,
inefficient
delivery.
Lipid-based
nano-carriers,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers,
offer
promising
solution
enhancing
solubility,
stability,
targeted
delivery
these
compounds.
These
advanced
systems
improve
retention,
enable
controlled
release,
enhance
action
on
adipose
tissue
pathways.
Additionally,
functionalized
stimulus-responsive
nanocarriers
present
innovative
approaches
precision
obesity
treatment.
Despite
advancements,
challenges
remain
in
large-scale
production,
regulatory
approval,
safety.
Overcoming
barriers
critical
ensuring
successful
translation
nano-formulated
therapies.
This
review
explores
potential
lipid-based
nano-carriers
optimizing
efficacy
highlights
role
advancing
next-generation
management
Current Gene Therapy,
Journal Year:
2024,
Volume and Issue:
25(2), P. 92 - 112
Published: May 23, 2024
Lung
cancer
is
a
significant
cause
of
cancer-related
death
worldwide.
It
can
be
broadly
categorised
into
small-cell
lung
(SCLC)
and
Non-small
cell
(NSCLC).
Surgical
intervention,
radiation
therapy,
the
administration
chemotherapeutic
medications
are
among
current
treatment
modalities.
However,
application
chemotherapy
may
limited
in
more
advanced
stages
metastasis
due
to
potential
for
adverse
effects
lack
selectivity.
Although
small-molecule
anticancer
treatments
have
demonstrated
effectiveness,
they
still
face
several
challenges.
The
challenges
at
hand
this
context
comprise
insufficient
solubility
water,
bioavailability
specific
sites,
effects,
requirement
epidermal
growth
factor
receptor
inhibitors
that
genetically
tailored.
Bio-macromolecular
drugs,
including
small
interfering
RNA
(siRNA)
messenger
(mRNA),
susceptible
degradation
when
exposed
bodily
fluids
humans,
which
reduce
stability
concentration.
In
context,
nanoscale
delivery
technologies
utilised.
These
agents
offer
encouraging
prospects
preservation
regulation
pharmaceutical
substances,
addition
improving
medications.
Nanocarrier-based
systems
possess
notable
advantage
facilitating
accurate
sustained
drug
release,
as
opposed
traditional
systemic
methodologies.
primary
focus
scientific
investigation
has
been
augment
therapeutic
efficacy
nanoparticles
composed
lipids.
Numerous
techniques
implemented
treat
various
respiratory
ailments,
such
cancer.
exhibited
mitigate
limitations
associated
with
conventional
therapy.
As
an
illustration,
applying
nanocarriers
enhance
drugs
prevent
bio-macromolecular
drugs.
Furthermore,
these
devices
administer
controlled
extended
fashion,
thereby
augmenting
intervention's
effectiveness
reducing
reactions.
despite
promising
results,
remain
must
addressed.
Multiple
factors
necessitate
consideration
contemplating
medical
interventions.
To
begin
with,
advancement
efficient
methods
imperative.
addition,
comprehensive
toxicity
required.
Finally,
additional
research
needed
comprehend
treatments'
enduring
ramifications.
Despite
challenges,
field
nanomedicine
demonstrates
considerable
promise
enhancing
therapy
other
diseases.
