Solid Lipid Nanoparticles for Skin Delivery of Trans-Resveratrol: Impact of Preparation Methods on Formulation Stability

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 7 - 7

Published: Jan. 7, 2025

Trans-resveratrol (RES) is a natural polyphenol known for its antioxidant, anti-inflammatory, and anti-aging properties, making it highly valuable in cosmetic applications. Solid lipid nanoparticles (SLNs) offer promising solution to enhance RES’s stability cutaneous availability. This study aimed develop characterize SLNs encapsulating RES enhanced skin delivery. Multiple methodologies were evaluated determine the impact of preparation methods on formulation stability. formulated using stearic acid, soy phosphatidylcholine, polysorbate 80, cetyltrimethylammonium bromide, poloxamer 407, with variations heating temperatures homogenization techniques. Stability assessments conducted over 90 days, examining organoleptic properties hydrodynamic diameter, polydispersity index, zeta potential. Encapsulation efficiency permeation studies performed investigate efficacy delivering RES. Results demonstrated that formulations prepared Ultra Turrax at 24,000 rpm higher exhibited smaller particle sizes. The selected formulations, F1 (prepared 80 °C) F2 70 presented encapsulation efficiencies 70% 72%, respectively. Skin confirmed ability facilitate delivery through skin. concludes are suitable carriers delivery, offering improved sustained release, thus representing approach topical applications leverage therapeutic benefits.

Language: Английский

Resveratrol loaded zein nanoparticles for inhibiting proliferation of osteosarcoma cells: synthesis, characterization, release profile, and cytotoxicity

OpenNano, Journal Year: 2025, Volume and Issue: unknown, P. 100237 - 100237

Published: Feb. 1, 2025

Language: Английский