Trends in mosquito species distribution modeling: insights for vector surveillance and disease control

Parasites & Vectors, Journal Year: 2023, Volume and Issue: 16(1)

Published: Aug. 28, 2023

Species distribution modeling (SDM) has become an increasingly common approach to explore questions about ecology, geography, outbreak risk, and global change as they relate infectious disease vectors. Here, we conducted a systematic review of the scientific literature, screening 563 abstracts identifying 204 studies that used SDMs produce estimates for mosquito species. While number employing SDM methods increased markedly over past decade, overwhelming majority single method (maximum entropy modeling; MaxEnt) focused on human vectors or their close relatives. The regional models were developed areas in Africa Asia, while more localized efforts most North America Europe. Findings from this study highlight gaps taxonomic, geographic, methodological foci current literature mosquitoes can guide future geography mosquito-borne risk.

Language: Английский

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A Systematic Review on the Viruses of Anopheles Mosquitoes: The Potential Importance for Public Health

Tropical Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 8(10), P. 459 - 459

Published: Sept. 26, 2023

Anopheles mosquitoes are the vectors of Plasmodium, etiological agent malaria. In addition, funestus and gambiae main O’nyong-nyong virus. However, research on viruses carried by is scarce; thus, possible transmission still unexplored. This systematic review was out to identify studies that report in natural populations or virus infection laboratory-reared mosquitoes. The databases reviewed were EBSCO-Host, Google Scholar, Science Direct, Scopus PubMed. After identification screening candidate articles, a total 203 original included reported variety detected populations. total, 161 54 species from 41 countries worldwide registered. laboratory studies, 28 15 evaluated for mosquito viral capacity infection. encompassed 25 families arboviruses, probable arboviruses Insect-Specific Viruses (ISVs). Insights after performing this include need (1) better understanding Anopheles-viral interactions, (2) characterizing virome—considering public health importance potentially transmitted significance finding with biological control activity—and (3) virological surveillance Anopheles, especially current context environmental modifications may potentiate expansion distribution.

Language: Английский

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Lack of abundant core virome in Culex mosquitoes from a temperate climate region despite a mosquito species-specific virome

mSystems, Journal Year: 2024, Volume and Issue: 9(6)

Published: May 14, 2024

In arthropod-associated microbial communities, insect-specific viruses (ISVs) are prevalent yet understudied due to limited infectivity outside their natural hosts. However, ISVs might play a crucial role in regulating mosquito populations and influencing arthropod-borne virus transmission. Some studies have indicated core virome mosquitoes consisting of mostly ISVs. Employing single metagenomics, we comprehensively profiled the native invasive species Belgium. This approach allowed for accurate host determination, prevalence assessment

Language: Английский

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No detectable fitness cost of infection by cell-fusing agent virus in Aedes aegypti mosquitoes

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 1, 2024

mosquitoes are well-known vectors of arthropod-borne viruses (arboviruses). Mosquitoes more frequently infected with insect-specific (ISVs) that cannot infect vertebrates. Some ISVs interfere arbovirus replication in mosquito vectors, which has gained attention for potential use against transmission. Cell-fusing agent virus (CFAV), a widespread ISV, can reduce dissemination

Language: Английский

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Highly divergent and diverse viral community infecting sylvatic mosquitoes from Northeast Brazil

Journal of Virology, Journal Year: 2024, Volume and Issue: 98(8)

Published: July 12, 2024

Mosquitoes can transmit several pathogenic viruses to humans, but their natural viral community is also composed of a myriad other such as insect-specific (ISVs) and those that infect symbiotic microorganisms. Besides growing number studies investigating the mosquito virome, majority are focused on few urban species, relatively little known about virome sylvatic mosquitoes, particularly in high biodiverse biomes Brazilian biomes. Here, we characterized RNA 10 species from Atlantic forest remains at sylvatic-urban interface Northeast Brazil employing metatranscriptomic approach. A total 16 families were detected. The phylogenetic reconstructions 14 revealed sequences putative ISVs. positioning and, most cases, association with RNA-dependent polymerase amino acid divergence suggests here represent least 34 new species. Therefore, predominantly highly divergent highlighting limited knowledge still have mosquitoes general. Moreover, found none recovered shared between investigated, only one showed identity virus detected sampled Peru, South America. These findings add further in-depth understanding interactions coevolution environments.

Language: Английский

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Sylvatic Mosquito Viromes in the Cerrado Biome of Minas Gerais, Brazil: Discovery of New Viruses and Implications for Arbovirus Transmission

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1276 - 1276

Published: Aug. 9, 2024

Studies on animal virome have mainly concentrated chordates and medically significant invertebrates, often overlooking sylvatic mosquitoes, constituting a major part of mosquito species diversity. Despite their potential role in arbovirus transmission, the viromes mosquitoes remain largely unexplored. These may also harbor insect-specific viruses (ISVs), affecting arboviral transmission dynamics. The Cerrado biome, known for rapid deforestation its status as biodiversity hotspot, offers an ideal setting investigating due to zoonotic spillover risks from land use changes. This study aimed characterize collected various locations within Minas Gerais state, Brazil. total RNA was extracted pools

Language: Английский

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Effect of chikungunya, Mayaro and Una virus coinfection on vector competence of Aedes aegypti mosquitoes

One Health, Journal Year: 2025, Volume and Issue: 20, P. 100991 - 100991

Published: Feb. 7, 2025

The mosquito-borne alphaviruses chikungunya (CHIKV), Mayaro (MAYV) and the lesser known Una (UNAV) are currently co-circulating in Latin America, sharing their geographical ecological niche with Aedes aegypti mosquito. sylvatic MAYV cycle unknown of UNAV could possibly spill over become urban transmission cycles involving Ae. aegypti. Despite potential impact on public health, we know little about arboviral coinfections humans, animals or mosquitoes. Especially effect by mosquitoes is understudied. We investigated vector competence for single, dual, triple exposures UNAV, CHIKV, provided simultaneously an infectious blood meal. Mosquitoes were incubated ten days at 28 °C 70 % humidity. After RNA extractions from mosquito bodies saliva, presence relative quantity each virus coinfected was determined. show that can infected all three viruses simultaneously, transmit least two a single bite after dual infection. Additionally, first time competent infections do not influence competence. In coinfections, however, total viral load carried decreases, lowering potential. Understanding how affect arbovirus biology essential assessing health risks. However, emerging aegypti-vectored arboviruses One Health concern, as environmental changes will increasingly drive geographic distributions viruses, vectors, hosts future.

Language: Английский

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Insect-specific virus platforms for arbovirus vaccine development

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Certain insect-specific viruses (ISVs), specifically the mosquito alphaviruses, Eilat and Yada viruses, orthoflaviviruses, Binjari, Aripo, YN15-283-02 Chaoyang have emerged as potential platforms for generation of whole virus vaccines human veterinary applications. These ISVs are remarkably tolerant substitution their structural polyproteins with those alphaviruses orthoflaviviruses that pathogenic in humans and/or animals. The resulting ISV-based chimeric been evaluated mouse models demonstrated safety efficacy non-human primates, crocodiles pigs. Targets include chikungunya, Venezuelan eastern equine encephalitis, dengue, Zika, yellow fever, Japanese encephalitis West Nile viruses. provide authentically folded tertiary quaternary virion particle structures to immune system, a key feature induction protective antibody responses. manufactured C6/36 or C7-10 cell lines, where they grow high titers, but do not replicate vertebrate vaccine recipients. This review discusses progress these emerging technologies addresses challenges related adjuvanting, safety, manufacturing.

Language: Английский

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Metagenomic analysis evidences a core virome in Anopheles darlingi from three contrasting Colombian ecoregions

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320593 - e0320593

Published: April 30, 2025

Anopheles darlingi is a main malaria vector in the neotropical region, but its viral component not well studied, especially neotropics. This work aimed to analyze virome from endemic regions of Colombia. Specimens were collected Bajo Cauca, Chocoan Pacific and northwestern Amazonas analyzed using an RNA-Seq approach. Results revealed variety RNA sequences with homology those Insect-Specific Viruses belonging Rhabdoviridae, Partitiviridae, Metaviridae, Tymoviridae, Phasmaviridae, Totiviridae, Ortervirales Riboviria. Despite geographical ecological differences among regions, An. composition remains consistent different areas, core group operational taxonomic units-vOTUs shared by populations. Furthermore, diversity analysis uncovered greater dissimilarities sequence mosquitoes geographically distant particularly evident between populations located at both sides Andes Mountain range. study provides first characterization metavirome Colombia lays foundation for future research on complex interactions viruses, hosts, microbiota; it also opens new line investigation viruses

Language: Английский

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RNA sequencing analysis of viromes of Aedes albopictus and Aedes vexans collected from NEON sites

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(20)

Published: May 12, 2025

Climate change is significantly impacting the geographic range of many animal species and their associated microorganisms, hence influencing emergence vector-borne diseases. Mosquito-borne viruses represent a potential major reservoir human pathogens, highlighting need for improved understanding ecological factors with variation in mosquito viral community (virome). Here, subtractive hybridization method coupled RNAseq individual specimens was used to profile RNA viromes co-occurring Aedes albopictus vexans mosquitoes across 2,000 km spatial scale. Samples were collected archived by National Ecological Observatory Network (NEON) from four ecologically variable sites Southeastern United States between 2018 2019. Results multivariate analysis suggest that are an important factor composition. Significantly higher diversity detected A. compared A.vexans . However, season, year, site sample collection did not show strong association virome profiles, supporting hypothesis unique host (e.g., larval habitat or vector competence) influence structure viromes.

Language: Английский

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