The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: Jan. 30, 2025

There are 275,000 new cases of oral cancer (OC) per year, making it the sixth most common in world. Severe adverse effects, including loss function, deformity, and systemic toxicity, familiar with traditional therapies such as radiation, chemotherapy, surgery; due to their unique properties, nanoparticles (NPs) have emerged a superior alternative over chemo/radiotherapy surgery targeting capability, bioavailability, compatibility, high solubility. Due metallic NPs garnered significant attention OC control. In addition fact that metal may be harmful human cells, reactive chemicals used make them pose same risk, which limits use medicine. Green synthesis (GS) is novel strategy uses biological materials like yeast, bacteria, fungi, plant extracts. Compared more chemical processes, these environmentally benign manageable for living organisms. This article summarizes GS made metals oxides anticancer effects on OC. The method's potential benefits drawbacks advancing NPs' shaping therapy's future were also discussed.

Language: Английский

A novel plant-based approach for synthesis of iron oxide nanoparticles and cancer therapy

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 26, 2025

Language: Английский

Redefining cancer photodynamic therapy with gold nanoparticles

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Despite advancements made in treatment options, cancer continues to be one of the leading causes death worldwide. Photodynamic therapy (PDT) has gained attention as a minimally invasive and highly selective option for cancer. However, challenges due hydrophobicity photosensitizers their poor tumor selectivity have limited use therapy. Recent developments nanotechnology, particularly gold nanoparticles (AuNPs), help overcome these challenges. AuNPs provide stable biocompatible platform deliver photosensitizers, improving solubility, stability, ability target tumors while reducing side effects. Functionalized take advantage mechanisms like enhanced permeability retention (EPR) effect active targeting, reactive oxygen species (ROS) production overall therapeutic efficacy. This review explores innovations AuNP-based PDT systems, including ligand-functionalized nanoparticles, bioresponsive coatings, theranostic approaches that combine imaging with By delving into important aspects synthesis, characterization, functionalization, we show how improve delivery performance photosensitizers. For instance, systems functionalized prostate-specific membrane antigen (PSMA) shown increased precision efficacy vivo. These are paving way more targeted safer treatments, establishing promising approach developing effective oncological therapies greater fewer

Language: Английский