Tumor-derived exosomes as promising tools for cancer diagnosis and therapy DOI Creative Commons
Xirui Wang, Yanfang Liu, Yao‐Wen Jiang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Mounting evidences indicated that cancer cell-derived exosomes (TDEs) contribute to progression and metastasis by reshaping the tumor microenvironment (TME) interfering immunity response. TDEs contain unique biomolecular cargo, consisting of protein, nucleic acid, lipids. In recent years, have been used as potential disease therapeutics diagnosis biomarkers prime candidates delivery tools for treatment. present review, we firstly summarized biogenesis characteristic. Also, role in cell invasiveness, drug resistance, immunosuppression was mentioned via cell-cell communication. Additionally, concluded current strategies TDE-based therapy, including inhibition clearance, usage therapeutic vector vaccines. Furthermore, combination therapy with engineered were summarized, such radiotherapy, photodynamic photothermal sonodynamic therapy. Consequently, above opens up novel interesting opportunities prognosis based on TDEs, which is prospective accelerate clinical translation

Language: Английский

Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology DOI Creative Commons
Shuang Ma, Ying Lü,

S.J. Sui

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides comprehensive review of methodologies for evaluating including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, single-fiber experiments to assess quality performance. Furthermore, it elucidates mechanisms, applications, limitations various modalities, immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, combined chemoimmunotherapy, while examining their effects on function systemic responses. Key findings indicate that although is effective in augmenting antitumor immunity, frequently induces muscle-related adverse such as weakness, fatigue, or damage, primarily mediated by cytokine release activation. underscores significance niches within microenvironment influencing treatment outcomes proposes strategies optimize therapy through personalized regimens combinatorial approaches. highlights need further formation interactions muscle-tumor. Our crucial advancing efficacy immunotherapy, reducing effects, ultimately improving survival rates life patients with cancer.

Language: Английский

Citations

0
Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy DOI Creative Commons
Shuang Ma, Guangyu Zhao,

S.J. Sui

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing wasting and functional decline cancer patients. In this study, we review mechanisms by influences muscle, focusing immune-related myositis, inflammation, metabolic alterations within tumor microenvironment (TME). The key methodologies, including biomechanical assessment techniques such as electrical impedance myography ultrasound imaging, are discussed provide valuable insights into process that maintain integrity function patients receiving immunotherapy. Moreover, dual of suppression damage described, revealing significance inflammatory cytokines, checkpoints, disturbances TME. Importantly, propose combination therapies integrating nutritional interventions or anti-inflammatory potential approaches for mitigating wasting. This study highlights need deeper investigations optimize improve its efficacy preserving health, thereby improving patient outcomes quality life.

Language: Английский

Citations

0
Liposome-mediated anticancer drug delivery strategies for advancing brain tumor therapy DOI
Mohsen Rahmanian, Fatemeh Oroojalian, Prashant Kesharwani

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114001 - 114001

Published: May 1, 2025

Language: Английский

Citations

0
Pancancer analysis of DNA damage repair gene mutations and their impact on immune regulatory gene expression DOI Creative Commons

Kanchana Yadav,

Trishala Das,

Andrew M. Lynn

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Abstract DNA damage is a key factor in many human disorders, including cancer, chronic inflammation, and early aging. Genes involved repair (DDR) not only maintain genomic stability but also contribute to immune responses by regulating the expression of antimicrobial peptides ligands that activate receptors. Various components response (DDR), sensors, transducer kinases, effector proteins, are capable activating diverse immunological signaling pathways. While DDR gene mutations common cancers, their effects on characteristics well understood. We investigated how genes influence regulatory genes, stimulators, inhibitors, related major histocompatibility complex (MHC) pathway. Using data from The Cancer Genome Atlas (TCGA) mutation cBioPortal, we analyzed 264 DDR-related 66 genes. These were clustered categorized using Metascape, an integrative bioinformatics tool applies enrichment-based analysis group functionally into clusters. further validated through literature review GeneCards database. scored change identify differentially expressed MHC-related Our revealed positive negative correlations between modulators. findings could help guide future cancer treatments based biomarkers immunotherapy strategies.

Language: Английский

Citations

0
Tumor-derived exosomes as promising tools for cancer diagnosis and therapy DOI Creative Commons
Xirui Wang, Yanfang Liu, Yao‐Wen Jiang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Mounting evidences indicated that cancer cell-derived exosomes (TDEs) contribute to progression and metastasis by reshaping the tumor microenvironment (TME) interfering immunity response. TDEs contain unique biomolecular cargo, consisting of protein, nucleic acid, lipids. In recent years, have been used as potential disease therapeutics diagnosis biomarkers prime candidates delivery tools for treatment. present review, we firstly summarized biogenesis characteristic. Also, role in cell invasiveness, drug resistance, immunosuppression was mentioned via cell-cell communication. Additionally, concluded current strategies TDE-based therapy, including inhibition clearance, usage therapeutic vector vaccines. Furthermore, combination therapy with engineered were summarized, such radiotherapy, photodynamic photothermal sonodynamic therapy. Consequently, above opens up novel interesting opportunities prognosis based on TDEs, which is prospective accelerate clinical translation

Language: Английский

Citations

0