Photovoltaic neurointerface based on aluminum antimonide nanocrystals DOI Creative Commons
Mertcan Han, Houman Bahmani Jalali, Erdost Yıldız

et al.

Communications Materials, Journal Year: 2021, Volume and Issue: 2(1)

Published: Feb. 19, 2021

Abstract Light activated modulation of neural activity is an emerging field for the basic investigation systems and development new therapeutic methods such as artificial retina. Colloidal inorganic nanocrystals have great potential interfaces due to their adjustable optoelectronic properties via high-level structural, compositional, size control. However, toxic heavy metal content (e.g., cadmium, mercury), electrochemical coupling cells low photon-to-current efficiency limit effective use. Here, we introduce use aluminum antimonide (AlSb) cell interfacing layer capacitive stimulation in blue spectrum. We demonstrate successful photostimulation primary hippocampal neurons below ocular safety limits. In addition, our device shows high biocompatibility vitro passive accelerated ageing tests indicate a functional lifetime over 3 years showing feasible chronic implants. that nanocrystal biointerfaces hold promise future bioelectronics protheses.

Language: Английский

Simultaneous perception of prosthetic and natural vision in AMD patients DOI Creative Commons
Daniel Palanker, Y. Le Mer, Saddek Mohand‐Saïd

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 26, 2022

Loss of photoreceptors in atrophic age-related macular degeneration (AMD) results severe visual impairment. Since the low-resolution peripheral vision is retained such conditions, restoration central should not jeopardize surrounding healthy retina and allow for simultaneous use natural prosthetic sight. This interim report, prespecified study protocol, presents first clinical with a photovoltaic substitute providing AMD. In this open-label single group feasibility trial (NCT03333954, recruitment completed), five patients geographic atrophy have been implanted wireless 2 x mm-wide 30 µm-thick device, having 378 pixels 100 µm size. All 5 achieved primary outcome by demonstrating perception former scotoma. The four subretinal placement chip demonstrated secondary outcome: Landolt acuity 1.17 ± 0.13 pixels, corresponding to Snellen range 20/460-20/565. With electronic magnification up factor 8, 20/63-20/98. Under room lighting could simultaneously their remaining eye fellow eye.

Language: Английский

Citations

93
Regenerative and restorative medicine for eye disease DOI
Russell N. Van Gelder, Michael F. Chiang, Michael A. Dyer

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 1149 - 1156

Published: June 1, 2022

Language: Английский

Citations

72
Metaverse Wearables for Immersive Digital Healthcare: A Review DOI Creative Commons
Kisoo Kim,

Hyosill Yang,

Ji-Hun Lee

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Sept. 22, 2023

The recent exponential growth of metaverse technology has been instrumental in reshaping a myriad sectors, not least digital healthcare. This comprehensive review critically examines the landscape and future applications wearables toward immersive key technologies advancements that have spearheaded metamorphosis are categorized, encapsulating all-encompassed extended reality, such as virtual augmented mixed other haptic feedback systems. Moreover, fundamentals their deployment assistive healthcare (especially for rehabilitation), medical nursing education, remote patient management treatment investigated. potential benefits integrating into paradigms multifold, encompassing improved prognosis, enhanced accessibility to high-quality care, high standards practitioner instruction. Nevertheless, these without inherent challenges untapped opportunities, which span privacy protection, data safeguarding, innovation artificial intelligence. In summary, research trajectories circumvent hurdles also discussed, further augmenting incorporation within infrastructures post-pandemic era.

Language: Английский

Citations

45
Frontier applications of retinal nanomedicine: progress, challenges and perspectives DOI Creative Commons

Zhimin Tang,

Fuxiang Ye, Ni Ni

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Language: Английский

Citations

2
Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas DOI Creative Commons
Naïg Aurélia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

et al.

Communications Materials, Journal Year: 2021, Volume and Issue: 2(1)

Published: March 5, 2021

Abstract Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade clinical trials highlighted quantitative limitations hampering possibility reaching this goal. A key challenge retinal stimulation is to independently activate neurons over large portion subject’s visual field. Reaching such goal would significantly improve perception accuracy implants’ users, along with their spatial cognition, attention, ambient mapping and interaction environment. Here we show wide-field, high-density high-resolution photovoltaic epiretinal prosthesis for artificial (POLYRETINA). The embeds 10,498 physically functionally independent pixels, allowing wide coverage stimulation. Single-pixel illumination reproducibly induced network-mediated responses from ganglion cells at safe irradiance levels. Furthermore, POLYRETINA allowed response discrimination high resolution equivalent pixel pitch (120 µm) thanks mechanism. This approach could allow mid-peripheral patients retinitis pigmentosa.

Language: Английский

Citations

87
Bioengineering strategies for restoring vision DOI
Jasmina Cehajic‐Kapetanovic, Mandeep S. Singh, Eberhart Zrenner

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 7(4), P. 387 - 404

Published: Jan. 31, 2022

Language: Английский

Citations

57
Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats DOI Creative Commons
Bing-Yi Wang, Zhijie Chen, Mohajeet Bhuckory

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 4, 2022

Abstract Localized stimulation of the inner retinal neurons for high-acuity prosthetic vision requires small pixels and minimal crosstalk from neighboring electrodes. Local return electrodes within each pixel limit crosstalk, but they over-constrain electric field, thus precluding efficient with subretinal smaller than 55 μm. Here we demonstrate a high-resolution based on novel design photovoltaic array, where field confinement is achieved dynamically, leveraging adjustable conductivity diodes under forward bias to turn designated into transient returns. We validated computational modeling in such an optically-controlled circuit by in-vitro in-vivo measurements. Most importantly, using this strategy, demonstrated that grating acuity 40 μm matches pitch, while 20 pixels, it reaches 28 natural visual resolution rats. This method enables customized shaping individual thickness distance implant, paving way higher atrophic macular degeneration.

Language: Английский

Citations

47
POLYRETINA restores light responses in vivo in blind Göttingen minipigs DOI Creative Commons
Paola Vagni, Marta Jole Ildelfonsa Airaghi Leccardi,

Charles-Henri Vila

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 27, 2022

Abstract Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of outer retinal layer. Available technologies provide only a small field view: significant limitation totally people. To overcome this problem, we recently proposed large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, report vivo assessment First, characterise model chemically-induced blindness Göttingen minipigs. Then, develop test minimally invasive injection procedure to insert implant into eye. Last, show that POLYRETINA restores light-evoked cortical responses animals at safe irradiance levels. These results indicate holds patients retinitis pigmentosa.

Language: Английский

Citations

40
Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems DOI
Onuralp Karatum,

Min-Jun Gwak,

Junghun Hyun

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(10), P. 3326 - 3352

Published: Jan. 1, 2023

This review summarizes optical nanomaterials, devices, and systems for neuromodulation. We describe their structures, working principles bioelectronic applications with challenges prospects.

Language: Английский

Citations

27
Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration DOI Creative Commons
Gengxi Lu, Chen Gong, Yizhe Sun

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 27, 2024

Abstract Retinal degeneration, a leading cause of irreversible low vision and blindness globally, can be partially addressed by retina prostheses which stimulate remaining neurons in the retina. However, existing electrode-based treatments are invasive, posing substantial risks to patients healthcare providers. Here, we introduce completely noninvasive ultrasonic prosthesis, featuring customized ultrasound two-dimensional array allows for simultaneous imaging stimulation. With synchronous three-dimensional guidance auto-alignment technology, prosthesis generate programmed waves dynamically precisely form arbitrary wave patterns on Neuron responses brain’s visual center mirrored these patterns, evidencing successful artificial creation, was further corroborated behavior experiments. Quantitative analysis spatial-temporal resolution field view demonstrated advanced performance elucidated biophysical mechanism retinal As could lead more effective, widely acceptable treatment blind patients. Its real-time imaging-guided stimulation strategy with single array, also benefit neurostimulation other diseases.

Language: Английский

Citations

9