Survey of Ophthalmology, Journal Year: 2024, Volume and Issue: 70(3), P. 563 - 582
Published: Dec. 18, 2024
Language: Английский
Survey of Ophthalmology, Journal Year: 2024, Volume and Issue: 69(6), P. 882 - 892
Published: July 3, 2024
The science of diabetes care has progressed to provide a better understanding the oxidative and inflammatory lesions pathophysiology neurovascular unit within retina (and brain) that occur early in diabetes, even prediabetes. Screening for retinal structural abnormalities, traditionally been performed by fundus examination or color photography; however, these imaging techniques detect disease only when there are sufficient lesions, predominantly hemorrhagic, recognized late process after significant neuronal apoptosis atrophy, as well microvascular occlusion with alterations vision. Thus, interventions have primarily oriented toward later-detected stages, clinical trials, while demonstrating slowing progression, demonstrate minimal visual improvement modest reduction continued loss over prolonged periods. Similarly, vision measurement utilizing charts detects problems function late, begins most often parafoveally increasing number progressive expansion, including into fovea. While acuity long used define endpoints such current methods reviewed herein found be imprecise. We review improved testing newer recommendation must utilized discover evaluate injury earlier process, prediabetic state. This would allow therapy ocular systemic pharmacologic treatments lower neuro-inflammatory processes eye brain. also may include newer, micropulsed laser that, if applied during cascade, should result normalized without adverse treatment effects standard photocoagulation therapy.
Language: Английский
Citations
7
Survey of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
6
Clinical and Experimental Ophthalmology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
To compare the performance of high-resolution microperimetry testing against standard automated perimetry (SAP) for detecting glaucomatous damage seen on optical coherence tomography (OCT) scans. 250 eyes from 200 individuals underwent a hemifield using stimulus pattern optimised to sample typical arcuate patterns visual field loss in glaucoma. SAP was performed 24-2 pattern. The presence each subsequently independently assessed by two graders based circumpapillary OCT circle scan, 6×6 mm optic disc-centred volume and 15×15 widefield scan. hemifield-based mean total deviation (MTD) pointwise sensitivity (PSD) were both associated with multivariable logistic regression analyses (p ≤ 0.046). Prediction models developed these parameters showed significantly higher compared (partial area under receiver operating characteristic curve [pAUC] = 0.86 0.75 respectively; p 0.007). decreased decreasing resolution when MTD PSD values derived every second, third, sixth test locations (pAUC 0.85 [p 0.16], 0.044] 0.84 < 0.001] respectively), but they all better than 0.028 all). High-resolution enabled improved SAP, highlighting potential value fundus-tracking higher-resolution sampling detection loss.
Language: Английский
Citations
0
Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(12), P. 17 - 17
Published: Oct. 9, 2024
To compare the diagnostic accuracy of thickness measurements individual and combined macular retinal layers to discriminate 188 glaucomatous 148 glaucoma suspect eyes from 362 healthy control (HC) on a pixel-by-pixel basis.
Language: Английский
Citations
0
Published: June 14, 2024
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 25, 2024
The Rapid Campimetry (RC), a kinetic visual field test proved to reliably detect defects within the central 10° degrees, most crucial part for acuity and quality of life, affected even at very early stages glaucoma, short measurement epoch, ~ 1 min. This study aims further investigate RC correspondence with standard tests in namely automated perimetry (SAP) optical coherence tomography (OCT) (VF). For this purpose, we included 41 participants, [21 glaucoma (GLA, mean age: 65.9 ± 12.4; 12 preperimetric eyes 11 VF defects) 20 healthy controls (HC; 65.0 10.3); eyes]. At first, compared rate detection/exclusion vs. SAP. Then, those (11 eyes), investigated 68-pointwise 10 - 2 layout functional structural (SF) correspondence, pointwise RC, SAP OCT
Language: Английский
Citations
0
Survey of Ophthalmology, Journal Year: 2024, Volume and Issue: 70(3), P. 563 - 582
Published: Dec. 18, 2024
Language: Английский
Citations
0