Association between the weight-adjusted waist index and age-related macular degeneration in US adults aged≥40 years: the NHANES 2005–2008

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 6, 2025

The association between the weight-adjusted waist index (WWI) and age-related macular degeneration (AMD) in US adults aged 40 years older is unknown. goal of this study was to ascertain a possible two. Data were obtained from National Health Nutrition Examination Survey (NHANES) 2005 2008. WWI calculated by dividing circumference (WC) square root body weight (kg). AMD diagnosed based on distinctive features observed fundus, using standard classification system. Weighted logistic regression analyses conducted investigate AMD. Spline smoothing threshold effects applied explore non-linear correlations. Subgroup performed identify underlying covariates affecting relationship. In addition, receiver operating characteristic (ROC) curve analysis used evaluate predictive power for A total 5,132 participants enrolled study. results showed significant positive risk (OR = 1.76 (1.52, 2.04); p < 0.0001). When categorized into tertiles, highest group exhibited stronger compared lowest tertile 2.90 (2.18, 3.86); 0.0001) model 1. subgroup interaction tests indicated that relationship stable across various populations. spline correlation incidence. Furthermore, mass (BMI), WC, weight, better predictability AMD, as shown ROC analysis. There exists older. WWI-related obesity management necessary prevention treatment

Language: Английский

Glucagon-like peptide-1 receptor agonists and the eye

Current Opinion in Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Purpose of review Glucagon-like peptide-1 receptor agonists (GLP-1RA) have gained popularity as an antidiabetic and weight loss agent with protective cardiovascular outcomes, but attention to the potential ocular side effects has grown. This aims consolidate existing evidence on GLP-1RA conditions such diabetic retinopathy (DR), nonarteritic ischemic optic neuropathy (NAION), glaucoma, age-related macular degeneration (AMD), idiopathic intracranial hypertension (IIH), dry eye disease (DED). Recent findings The effect DR is controversial likely linked rapid correction hemoglobin A1c levels. may be associated increased risk NAION, although mechanism remains elusive. Protective been shown against AMD, DED possibly due its anti-inflammatory properties, these medications decrease pressure in IIH. Summary As usage increases, further dedicated safety trials are key determining eye-related complications. Given limited prospective available proven systemic benefits medication, well certain diseases, use should generally not discouraged most patients. Regular ophthalmologic follow up important patients considered at higher adverse events.

Language: Английский

Liraglutide Attenuates FFA-Induced Retinal Pigment Epithelium Dysfunction via AMPK Activation and Lipid Homeostasis Regulation in ARPE-19 Cells

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3704 - 3704

Published: April 14, 2025

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly, and it characterized by oxidative stress, lipid dysregulation, dysfunction retinal pigment epithelium (RPE). A hallmark AMD presence drusen, extracellular deposits rich lipids, proteins, cellular debris, which are secreted RPE. These impair RPE function, promote chronic inflammation, accelerate disease progression. Despite advancements understanding pathogenesis, therapeutic strategies targeting dysregulation damage cells remain limited. This study evaluated effects liraglutide, glucagon-like peptide-1 receptor agonist (GLP-1RA), on free fatty acid (FFA)-induced ARPE-19 cells, widely used vitro model dysfunction. FFA treatment induced droplet accumulation, epithelial–mesenchymal transition (EMT), processes implicated Liraglutide significantly reduced mitigated suppressed EMT, as demonstrated high-content imaging, immunocytochemistry, molecular assays. Mechanistic analyses revealed that liraglutide activates AMP-activated protein kinase (AMPK), enhancing lipophagy restoring homeostasis. Furthermore, influenced exosome secretion, altering paracrine signaling reducing EMT markers neighboring cells. findings underscore liraglutide’s potential to address critical mechanisms underlying including EMT. provides foundational evidence supporting development GLP-1 agonists targeted therapies for AMD.

Language: Английский