Pediatric tonsillectomy: A short-term and long-term comparison of intracapsular versus extracapsular techniques

International Journal of Pediatric Otorhinolaryngology, Journal Year: 2020, Volume and Issue: 133, P. 109970 - 109970

Published: Feb. 25, 2020

Language: Английский

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A Proteomic Study Based on Home Quarantine Model Identifies NQO1 and Inflammation Pathways Involved in Adenoid Hypertrophy

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 723 - 735

Published: Jan. 1, 2025

Adenoid hypertrophy is a common disorder of childhood, and has an unclear pathogenesis. At the beginning COVID-19 pandemic, there was significant reduction in incidence adenoid children under long-term home quarantine, providing rare research model to explore pathogenesis treatment targets adenoidal children. Before during quarantine period, adenoids that underwent surgery were detected using label-free proteomics. Differences protein expression analyzed Gene Ontology, Kyoto Encyclopedia Genes Genomes, Set Enrichment Analysis, Protein-protein interaction, immunohistochemistry analysis. Long-term had profound impact on proteomics pediatric adenoids, with up-regulated down-regulated proteins 28 92 downregulated proteins, respectively. Functional enrichment analysis showed differentially expressed mainly enriched pathways such as leukocyte activation, inflammatory response, IL-1 production, Th17 cell differentiation, IL-17 signaling. In group, inflammation-related (TNF-α, IL-6), CD36, S100A2, considerably reduced, whereas NQO1 levels increased significantly, potentially alleviating hypertrophy. NQO1, NDUFS8, NDUFAF2 exhibited strong interactions. This study identified some candidate differential inflammation involved preschool

Language: Английский

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Impact of Adenotonsillectomy on Weight Gain in Children: A Systematic Review

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 270 - 270

Published: Feb. 23, 2025

Background: Adenotonsillectomy (AT) is a common surgical procedure among pediatrics, usually performed to treat obstructive sleep apnea (OSA), recurrent tonsillitis, and chronic adenoid hypertrophy. The aim of our systematic review evaluate the relationship between AT postoperative weight gain in children guide clinicians optimizing outcomes. Methods: A search was conducted following PRISMA guidelines PubMed, MEDLINE, Web Science databases. Studies evaluating weight, BMI, growth parameters before after were included. Data collaboratively extracted, including patient demographics, baseline status, comorbidities, long-term Results: Underweight (less than 3rd percentile on chart) who underwent often experienced “catch-up growth” while obese (above 95th had that exacerbated pre-existing obesity. These outcomes affected by factors such as age, comorbid conditions. Conclusions: can improve quality life underweight children, overweight or need careful monitoring nutrition counseling postoperatively mitigate excessive gain. More randomized trials are needed better understand metabolic implications refine clinical guidelines.

Language: Английский

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Surgical Management of Pediatric Obstructive Sleep Apnea: Efficacy, Outcomes, and Alternatives—A Systematic Review

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1652 - 1652

Published: Dec. 12, 2024

Aim: Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder. OSA affects approximately 2 million Italians, although only 3% receive a diagnosis and correct treatment. This review aims to provide an overview guide clinical decision making, ensuring that patients appropriate treatment for their specific condition. Material Methods: systematic was conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines registered at PROSPERO under ID CRD42024593760. A search on PubMed, Scopus, Web of Science performed find papers matched topic, using following Boolean keywords: (“obstructive apnea” OR “OSA” “sleep apnea, obstructive”) AND (“surgery” “surgical” “surgical techniques” treatment” “operative” procedures”) (“treatment” “therapy” “management”). Result: The electronic database found 20337 publications. After screening eligibility phase, 15 were chosen qualitative analysis. Conclusions: Adenotonsillectomy (AT) significantly improves secondary outcomes like behavioral issues quality life, compared watchful waiting with supportive care (WWSC). Alternative approaches such as tonsillotomy adenopharyngoplasty (APP) offer promising results, less postoperative discomfort lower complication rates. However, further large-scale studies are needed refine surgical techniques, assess long-term outcomes, optimize individualized strategies OSA.

Language: Английский

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Postoperative respiratory complications (PORC) in children with obstructive sleep apnea syndrome (OSAS) undergoing tonsillectomy: a narrative review

Acta Anaesthesiologica Belgica, Journal Year: 2024, Volume and Issue: 75(4), P. 375 - 383

Published: Nov. 1, 2024

Background: Obstructive sleep apnea syndrome (OSAS) in children often necessitates adenotonsillectomy as a primary intervention. However, postoperative respiratory complications (PORC) pose significant concerns this population, warranting careful management and monitoring. Objective: This narrative review aims to explore the prevalence, types, risk factors associated with PORC undergoing for OSAS. Additionally, current practices guidelines monitoring vulnerable population were investigated. Methods: A comprehensive search of PubMed Cochrane Library was conducted from January till March 2024 identify relevant studies. In addition, most recent American Academy Otolaryngology–Head Neck Surgery (AAO-HNS), Pediatrics (AAP), European Respiratory Society (ERS), French Oto-Rhino-Laryngology – Head (SFORL) German regarding pediatric included. Results: Twenty-nine studies addressing 12 focusing on prevalence ranged 1.4% 30%, desaturation being common. Identified included young age, presence severity OSAS, polysomnographic parameters, comorbidities, race, timing surgery, red cell width distribution. Guidelines varied recommendations inpatient admission post-adenotonsillectomy. Notably, evidence suggests potential high-care wards or post-anesthesia care units, selective use intensive units. Conclusion: Various have been identified predicting following (adeno)tonsillectomy OSAS such age < 3 years, PSG parameters. Recent suggest specific factors. High-care Post Anesthetic Care Units (PACUs) may suffice, avoiding unnecessary (PICU) admissions. “grey zone” approach before deciding further is promising, but its optimal duration needs more research. Prospective are needed refine validate guidelines, safely increasing number ambulatory (adeno)tonsillectomies.

Language: Английский

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Investigating the effect of a nasal decongestant on post-adenotonsillectomy respiratory complications in 25 paediatric patients with obstructive sleep apnoea: a pilot study

The Journal of Laryngology & Otology, Journal Year: 2019, Volume and Issue: 133(2), P. 110 - 114

Published: Feb. 1, 2019

Abstract Objective Adenotonsillectomy is frequently performed for obstructive sleep apnoea, but associated with post-operative respiratory morbidity. This study assessed the effect of paediatric Otrivine (0.05 per cent xylometazoline hydrochloride) on compromise. Methods Paediatric patients undergoing adenotonsillectomy apnoea were included. The control group ( n = 24) received no intervention and 25) intra-operative during induction using a nasal patty. Post-operative outcomes included pain, distress signs medical level required (simple, intermediate major). Results exhibited by 4 21 group. Sixty-eight simple interventions post-operatively, compared to 42 In group, interventions; none major interventions. 12.5 both Fifty reported pain 40 in Conclusion Intra-operative may reduce compromise apnoea. A randomised controlled trial required.

Language: Английский

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Tonsillar hypertrophy in a young infant

Pediatric Anesthesia, Journal Year: 2008, Volume and Issue: 18(12), P. 1242 - 1243

Published: Oct. 30, 2008

Language: Английский

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Correction: An Inconvenient Truth

Journal of Dental Sleep Medicine, Journal Year: 2023, Volume and Issue: 10(1)

Published: Jan. 10, 2023

Objectives/Introduction: To assess the dentofacial characteristics in children referred to a tertiary pediatric sleep center.Methods: A prospective cross-sectional study was conducted among (8 18 years old) who were undergoing evaluation at center.The data obtained included polysomnography results, profile photo, intraoral examination, and dental history questionnaire.Comparisons made between groups based on severity of obstructive apnea (OSA) (no, mild, or moderatesevere OSA), separately by surgical status (surgically naïve vs postadenotonsillectomy). Results: total 95 patients enrolled this study.Facial convexity moderate-severe OSA group showed statistically significant difference (P=0.02) when compared no group.Sixty-nine surgically 26 subjects postadenotonsillectomy group.No differences found groups.Conclusions: Facial varied different groups.There had prior adenotonsillectomy those naïve.Although these findings are limited due small sample size confounding variables, further is warranted better incorporate role assessments care treatment.Clinical Implication: The presence not be determined morphology alone, though there plausible quantifying advancing for evaluation.

Language: Английский

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