Light on osteoarthritic joint: from bench to bed DOI Creative Commons
Yingying Zhou, Junguo Ni, Chunyi Wen

et al.

Theranostics, Journal Year: 2021, Volume and Issue: 12(2), P. 542 - 557

Published: Dec. 15, 2021

Osteoarthritis (OA) is one of the rapidly growing disability-associated conditions with population aging worldwide. There a pressing need for precise diagnosis and timely intervention OA in early stage. Current clinical imaging modalities, including pain radiography, magnetic resonance imaging, ultrasound, optical coherent tomography, are limited to provide structural changes when damage has been established or advanced. It prompts further endeavors search novel functional molecular which potentially enables OA. A hybrid modality based on photothermal effects, photoacoustic drawn wide attention recent years seen variety biomedical applications, due its great performance yielding high-contrast high-resolution images from structure function, tissue down levels, animals human subjects. Photoacoustic witnessed gratifying potentials preliminary effects diagnosis. Regarding treatment OA, photothermal-triggered therapy exhibited attractions enhanced therapeutic outcomes. In this narrative review, we will discuss monitoring at different stages. Structural, functional, parameter associated joints captured by photoacoustics be summarized, forming perspective review. Photothermal applications related also discussed herein. Lastly, relevant potential solutions extend deeper situations have proposed. Although some aspects may not covered, mini review provides better understanding exciting innovations effects. inspire more explorations field towards earlier theranostics

Language: Английский

Functional photoacoustic imaging: from nano- and micro- to macro-scale DOI Creative Commons
Byullee Park,

Donghyeon Oh,

Jeesu Kim

et al.

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: June 19, 2023

Functional photoacoustic imaging is a promising biological technique that offers such unique benefits as scalable resolution and depth, well the ability to provide functional information. At nanoscale, has provided super-resolution images of surface light absorption characteristics materials single organelles in cells. microscopic macroscopic scales. techniques have precisely measured quantified various physiological parameters, oxygen saturation, vessel morphology, blood flow, metabolic rate oxygen, both human animal subjects. This comprehensive review provides an overview across multiple scales, from nano macro, highlights recent advances technology developments applications. Finally, surveys future prospects biomedical field.

Language: Английский

Citations

67
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo DOI
Qinrui Fu, Xiao Yang, Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

Citations

31
Practical review on photoacoustic computed tomography using curved ultrasound array transducer DOI
Jinge Yang, Seongwook Choi, Chulhong Kim

et al.

Biomedical Engineering Letters, Journal Year: 2021, Volume and Issue: 12(1), P. 19 - 35

Published: Dec. 19, 2021

Language: Английский

Citations

58
Photoacoustic Imaging in Biomedicine and Life Sciences DOI Creative Commons
Alexey Neprokin, Christian Broadway, Teemu Myllylä

et al.

Life, Journal Year: 2022, Volume and Issue: 12(4), P. 588 - 588

Published: April 14, 2022

Photo-acoustic imaging, also known as opto-acoustic has become a widely popular modality for biomedical applications. This hybrid technique possesses the advantages of high optical contrast and ultrasonic resolution. Due to distinct absorption properties tissue compartments main chromophores, photo-acoustics is able non-invasively observe structural functional variations within biological tissues including oxygenation deoxygenation, blood vessels spatial melanin distribution. The detection acoustic waves produced by pulsed laser source yields scaling range, from organ level photo-acoustic tomography sub-cellular or even molecular imaging. review discusses significant novel technical solutions utilising their applications in fields biomedicine life sciences.

Language: Английский

Citations

39
Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation DOI Creative Commons
Shumao Xu,

Marzia Momin,

Salahuddin Ahmed

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(42)

Published: Sept. 19, 2023

Abstract Optogenetic modulation of brain neural activity that combines optical and electrical modes in a unitary system has recently gained robust momentum. Controlling illumination spatial coverage, designing light‐activated modulators, developing wireless light delivery data transmission are crucial for maximizing the use neuromodulation. To this end, biocompatible electrodes with enhanced optoelectrical performance, device integration multiplexed addressing, transmission, multimodal operation soft systems have been developed. This review provides an outlook uniformly illuminating large areas while spatiotemporally imaging responses upon stimulation little artifacts. Representative concepts important breakthroughs, such as head‐mounted illumination, multiple implanted fibers, micro‐light‐delivery devices, discussed. Examples techniques incorporate electrophysiological monitoring presented. Challenges perspectives posed further research efforts toward high‐density interface modulation, potential nonpharmacological neurological disease treatments stimulation.

Language: Английский

Citations

27
Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review DOI Creative Commons

Joseph W. Fakhoury,

Juliana Benavides, Rayyan Manwar

et al.

Journal of Biomedical Optics, Journal Year: 2024, Volume and Issue: 29(S1)

Published: Jan. 12, 2024

SignificanceCutaneous melanoma (CM) has a high morbidity and mortality rate, but it can be cured if the primary lesion is detected treated at an early stage. Imaging techniques such as photoacoustic (PA) imaging (PAI) have been studied implemented to aid in detection diagnosis of CM.AimProvide overview different PAI systems applications for study CM, including determination tumor depth/thickness, cancer-related angiogenesis, metastases lymph nodes, circulating cells (CTCs), virtual histology, studies using exogenous contrast agents.ApproachA systematic review classification configurations was conducted based on their specific detection. This encompasses animal preclinical studies, offering insights into future potential clinic.ResultsPAI holds great clinical noninvasive technique disease management. PA microscopy predominantly used image angiogenesis surrounding tumors provide information characteristics. Additionally, tomography, with its increased penetration depth, demonstrated ability assess thickness. Both modalities shown promise detecting nodes CTCs, all-optical implementation developed perform histology analyses. Animal human successfully capability detect, visualize, classify, stage CM.ConclusionsPAI promising assessing status skin without surgical procedure. The modality microvasculature, visualize boundaries, detect fast label-free identify CTCs could metastatic status. In addition, useful monitoring treatment efficacy noninvasively.

Language: Английский

Citations

12
Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation DOI Creative Commons
Xi Yang, Chengpeng Chai, Yun-Hsuan Chen

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 40 - 40

Published: Jan. 7, 2025

Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging human beings. To explore improve generation propagation, we conducted the simulation image reconstruction of multi-layer brain model an embedded blood vessel under different source types. Based on results types sources, explored characteristics reconstructed images obtained from simulations without skull conditions. Specifically, focused detection vessels evaluated features, morphological characteristics, intensity variations in target using simulations. The showed that initial PA signals, corresponding to strongest weakest signals at positions within region were consistent, while images. This study revealed signal transmission conditions its impact reconstruction. It further provides theoretical basis selection sources.

Language: Английский

Citations

1
Monte Carlo-Based Optical Simulation of Optical Distribution in Deep Brain Tissues Using Sixteen Optical Sources DOI Creative Commons
Xi Yang, Chengpeng Chai, Hongzhi Zuo

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 260 - 260

Published: March 7, 2024

Optical-based imaging has improved from early single-location research to further sophisticated in 2D topography and 3D tomography. These techniques have the benefit of high specificity non-radiative safety for brain detection therapy. However, their performance is limited by complex tissue structures. To overcome difficulty successful applications, we conducted a simulation using 16 optical source types within model that based on Monte Carlo method. In addition, propose an evaluation method propagating depth resolution, specifically one distribution applications. Based results, best were determined each layer. The maximum corresponding extracted. field width was acquired different depths. minimum widths, as well source, determined. This paper provides reference evaluating resolution aspect, it potential optimize optical-based techniques.

Language: Английский

Citations

6
Deep Transfer Learning-Based Breast Cancer Detection and Classification Model Using Photoacoustic Multimodal Images DOI Creative Commons
Maha M. Althobaiti, Amal Adnan Ashour, Nada A. Alhindi

et al.

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: May 5, 2022

The rapid development of technologies in biomedical research has enriched and broadened the range medical equipment. Magnetic resonance imaging, ultrasonic optical imaging have been discovered by diverse communities to design multimodal systems, which is essential for applications. One important tools photoacoustic (PAMI) combines concepts optics systems. At same time, earlier detection breast cancer becomes reduce mortality. recent advancements deep learning (DL) models enable classification using images. This article introduces a novel social engineering optimization with transfer learning-based (SEODTL-BDC) model PAI. intention SEODTL-BDC technique detect categorize presence ultrasound Primarily, bilateral filtering (BF) applied as an image preprocessing remove noise. Besides, lightweight LEDNet employed segmentation In addition, residual network (ResNet-18) can be utilized feature extractor. Finally, SEO recurrent neural (RNN) model, named SEO-RNN classifier, allot proper class labels performance validation carried out benchmark dataset experimental outcomes pointed supremacy approach over existing methods.

Language: Английский

Citations

24
Advances in Injectable Hydrogels Based on Diverse Gelation Methods for Biomedical Imaging DOI

Chunxiang Mo,

Weiyao Zhang,

Kang Zhu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract The injectable hydrogels can deliver the loads directly to predetermined sites and form reservoirs increase enrichment retention of in target areas. preparation injection involve sol–gel transformation hydrogels, which is affected by factors such as temperature, ions, enzymes, light, mechanics (self‐healing property), pH. However, tracing injection, degradation, drug release from based on different ways gelation a major concern. To solve this problem, contrast agents are introduced into enabling be imaged under techniques fluorescence imaging, photoacoustic magnetic resonance radionuclide imaging. This review details methods for causing imageable hydrogels; discusses application containing various imaging techniques, finally explores potential challenges modes gelation.

Language: Английский

Citations

5