Theranostics,
Journal Year:
2021,
Volume and Issue:
12(2), P. 542 - 557
Published: Dec. 15, 2021
Osteoarthritis
(OA)
is
one
of
the
rapidly
growing
disability-associated
conditions
with
population
aging
worldwide.
There
a
pressing
need
for
precise
diagnosis
and
timely
intervention
OA
in
early
stage.
Current
clinical
imaging
modalities,
including
pain
radiography,
magnetic
resonance
imaging,
ultrasound,
optical
coherent
tomography,
are
limited
to
provide
structural
changes
when
damage
has
been
established
or
advanced.
It
prompts
further
endeavors
search
novel
functional
molecular
which
potentially
enables
OA.
A
hybrid
modality
based
on
photothermal
effects,
photoacoustic
drawn
wide
attention
recent
years
seen
variety
biomedical
applications,
due
its
great
performance
yielding
high-contrast
high-resolution
images
from
structure
function,
tissue
down
levels,
animals
human
subjects.
Photoacoustic
witnessed
gratifying
potentials
preliminary
effects
diagnosis.
Regarding
treatment
OA,
photothermal-triggered
therapy
exhibited
attractions
enhanced
therapeutic
outcomes.
In
this
narrative
review,
we
will
discuss
monitoring
at
different
stages.
Structural,
functional,
parameter
associated
joints
captured
by
photoacoustics
be
summarized,
forming
perspective
review.
Photothermal
applications
related
also
discussed
herein.
Lastly,
relevant
potential
solutions
extend
deeper
situations
have
proposed.
Although
some
aspects
may
not
covered,
mini
review
provides
better
understanding
exciting
innovations
effects.
inspire
more
explorations
field
towards
earlier
theranostics
ACS Photonics,
Journal Year:
2022,
Volume and Issue:
9(8), P. 2555 - 2578
Published: July 13, 2022
Photoacoustic
imaging
(PAI)
has
made
great
advances
in
availing
the
benefits
for
theragnostics
with
noninvasive,
nonionizing
and
high-resolution
features.
However,
PAI
effectively
visualizing
tumors
clinical
practice
is
still
lacking
investigation.
This
review
describes
various
integrated
diagnostic
strategies
involving
joint
multimodel
combined
innovative
contrast
agents
five
common
cancer
types.
multifunctional
a
second
near-infrared
(NIR-II,
1000–1700
nm)
biological
window,
providing
unprecedented
sensitivity
translatability.
We
summarize
state-of-art
status
of
diagnosis
different
types
cancers
from
ex
vivo
samples
to
humans.
The
detailed
elucidation
up-to-date
advanced
material
science
NIR-II
versatile
PAI-guided
reviewed
toward
preclinical
studies.
Future
perspective
directions
establish
all-in-one
boost
translation
are
highlighted.
IEEE Photonics Technology Letters,
Journal Year:
2023,
Volume and Issue:
35(8), P. 422 - 425
Published: March 6, 2023
A
novel
fiber
optic
Fabry-Perot
acoustic
sensor
based
on
a
grooved
diaphragm
has
been
proposed,
avoiding
the
decrease
of
resonant
frequency
due
to
enhanced
sensitivity
conventional
circular
diaphragm.
The
effect
structural
parameters
and
is
investigated
by
finite
element
simulation,
designed
fabricated
digital
light
processing
3D
printer.
Experimental
results
indicate
that
an
pressure
37.44
mV/Pa
@2
kHz
2.12
kHz,
where
about
2.07
times
almost
unchanged.
It
shown
proposed
advantages
simple
fabrication
process,
high
consistency,
excellent
applicability
for
weak
signal
detection.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(34), P. 8212 - 8234
Published: Jan. 1, 2024
Aging,
marked
by
dysregulated
cellular
systems,
gives
rise
to
a
spectrum
of
age-related
disorders,
including
neurodegeneration,
atherosclerosis,
immunosenescence,
and
musculoskeletal
issues.
These
conditions
contribute
significantly
the
global
disease
burden,
posing
challenges
health
span
economic
resources.
Current
therapeutic
approaches,
although
diverse
in
mechanism,
often
fall
short
targeting
underlying
pathologies.
They
fail
address
issues
compounded
altered
pharmacokinetics
elderly.
Nanotechnology
emerges
as
transformative
solution,
offering
tissue-specific
targeted
therapies
through
nanoparticles.
Functional
nanomaterials
(FNMs)
respond
internal
or
external
stimuli,
with
light-responsive
gaining
prominence.
Harnessing
benefits
deep
tissue
penetration
ease
manipulation
particularly
near-infrared
spectrum,
FNMs
present
innovative
strategies
for
comorbidities.
This
review
comprehensively
summarizes
potential
FNM-based
approaches
environments
also
emphasizes
advantages
over
traditional
treatment
modalities.
Specifically,
it
focuses
on
development
various
classes
functional
plasmonic
nanomaterials,
carriers,
upconversion
2D
transition
metal
oxide
dichalcogenide
carbon-based
against
age
related
diseases.
We
foresee
that
such
advanced
developments
field
nanotechnology
could
provide
new
hope
clinical
diagnosis
disorders.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(4), P. 409 - 409
Published: March 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
Photoacoustics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100722 - 100722
Published: April 1, 2025
Thrombosis
is
the
major
cause
of
ischemic
stroke
and
poses
a
serious
health
burden
globally.
Current
thrombolytic
strategies,
such
as
systematic
administration
recombinant
human
tissue
plasminogen
activator
(rt-PA),
are
challenged
by
limited
thrombolysis
efficiency
due
to
low
targeting
ability
short
plasma
half-life.
Here,
we
report
rapid
synergistic
strategy
that
integrates
sonothrombolysis
rt-PA
mediated
pharmacological
achieve
accurate
efficient
treatment
stroke.
The
(PLPA@PFP)
uses
platelet-biomimetic
membrane
carrier
deliver
both
perfluoropentane
(PFP)
rt-PA,
prolonging
half-life
effectively
accumulating
at
thrombus
within
0.5
hours.
Upon
exposure
focused
ultrasound,
PFP-based
cavitation
effects
significantly
enhance
breakdown
penetration,
enabling
sono/pharmacological
in
vitro
vivo.
High-resolution
photoacoustic
(PA)
imaging
provides
direct
assessment
vascular
reperfusion
following
therapeutic
intervention
murine
model
stroke,
offering
important
guidance
for
clinical
treatment.
Sensors,
Journal Year:
2022,
Volume and Issue:
22(23), P. 9541 - 9541
Published: Dec. 6, 2022
The
photoacoustic
effect
is
an
emerging
technology
that
has
sparked
significant
interest
in
the
research
field
since
acoustic
wave
can
be
produced
simply
by
incidence
of
light
on
a
material
or
tissue.
This
phenomenon
been
extensively
investigated,
not
only
to
perform
imaging
but
also
develop
highly
miniaturized
ultrasound
probes
provide
biologically
meaningful
information.
Therefore,
this
review
aims
outline
materials
and
their
fabrication
process
employed
as
targets,
both
biological
non-biological,
report
main
components'
features
achieve
certain
performance.
When
designing
device,
it
utmost
importance
model
at
early
stage
for
deeper
understanding
ease
optimization
process.
As
such,
throughout
article,
different
methods
already
implemented
are
introduced,
well
advantages
drawbacks
inherent
each
approach.
However,
some
remaining
challenges
still
faced
when
developing
such
system
regarding
its
fabrication,
modeling,
characterization,
which
discussed.
