Published: Jan. 1, 2024
Language: Английский
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Language: Английский
Citations
26
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Image quality assessment (IQA) is indispensable in clinical practice to ensure high standards, as well the development stage of machine learning algorithms that operate on medical images. The popular full reference (FR) IQA measures PSNR and SSIM are known tested for working successfully many natural imaging tasks, but discrepancies scenarios have been reported literature, highlighting gap between actual application. Such inconsistencies not surprising, images very different properties than images, neither targeted nor properly This may cause unforeseen problems applications due wrong judgement novel methods. paper provides a structured comprehensive overview examples where prove be unsuitable using kinds including real-world MRI, CT, OCT, X-Ray, digital pathology photoacoustic data. Therefore, improvement urgently needed particular this era AI increase reliability explainability beyond. Lastly, we will provide ideas future research suggest guidelines usage FR-IQA applied
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101028 - 101028
Published: March 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Language: Английский
Citations
8
Journal of Biomedical Optics, Journal Year: 2024, Volume and Issue: 29(S1)
Published: Jan. 16, 2024
SignificancePhotoacoustic (PA) imaging is an modality that integrates anatomical, functional, metabolic, and histologic insights. It has been a hot topic of medical research draws extensive attention.AimThis review aims to explore the applications PA clinical in human diseases, highlighting recent advancements.ApproachA systemic survey literature concerning utility was conducted, with particular focus on its application tumors, autoimmune inflammatory conditions, endocrine disorders.ResultsPA emerging as valuable tool for disease investigation. Information provided by can be used diagnosis, grading, prognosis multiple types tumors including breast ovarian neoplasms, thyroid nodules, cutaneous malignancies. facilitates monitoring activity diseases such rheumatoid arthritis, sclerosis, arteritis, bowel capturing dynamic functional alterations. Furthermore, unique capability visualizing vascular structure oxygenation levels aids assessing diabetes mellitus comorbidities function.ConclusionsDespite extant challenges, offers promising noninvasive precision long-term evaluation, anticipation, making it potentially significant practice.
Language: Английский
Citations
7
RMD Open, Journal Year: 2024, Volume and Issue: 10(1), P. e003880 - e003880
Published: Feb. 1, 2024
It is known that metabolic shifts and tissue remodelling precede the development of visible inflammation structural organ damage in inflammatory rheumatic diseases such as arthritides. As such, visualising measuring activity could be useful to identify biomarkers disease already a very early phase. Recent advances imaging have led so-called ‘metabolic imaging’ tools can detect these changes metabolism an increasingly accurate manner non-invasively. Nuclear techniques 18 F-D-glucose fibroblast activation protein inhibitor-labelled positron emission tomography are used yielded impressing results visualisation (including whole-body staging) both established arthritis. Furthermore, optical imaging-based bedside multispectral optoacoustic fluorescence advancing our understanding arthritis by identifying intra-articular correlate with onset high precision without need ionising radiation. Metabolic holds great potential for improving management patients contributing interception diagnostic accuracy, thereby paving way more personalised approach therapy strategies including preventive strategies. In this narrative review, we discuss state-of-the-art methods assessment inflammation, advocate extensive research endeavours elucidate their full field application rheumatology.
Language: Английский
Citations
7
Photoacoustics, Journal Year: 2023, Volume and Issue: 35, P. 100578 - 100578
Published: Dec. 1, 2023
Multispectral optoacoustic tomography (MSOT) allows non-invasive molecular disease activity assessment in adults with inflammatory bowel (IBD). In this prospective pilot-study, we investigated, whether increased levels of MSOT haemoglobin parameters corresponded to paediatric IBD patients, too. 23 children suspected underwent the terminal ileum and sigmoid colon standard validation (e.g. endoscopy). Crohn`s (CD) ulcerative colitis (UC) patients endoscopically confirmed activity, total (HbT) signals were CD (72.1 ± 13.0 a.u. vs. 32.9 15.4 a.u., p = 0.0049) UC (62.9 13.8 35.1 16.3 0.0311) as compared controls, respectively. Furthermore, correlated well SES-CD HbT (rs =0.69, 0.0075). Summarizing, is a novel technology for disease.
Language: Английский
Citations
11
Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Abstract The detection and complete eradication of early‐stage small tumors during hysteroscopy remains a significant clinical challenge in preserving fertility for young women with endometrial cancer (EC). purpose this study is to verify the feasibility CD47 as an optical molecular imaging (OMI) target human EC achieve precise localization identification hysteroscopic surgery. results demonstrated that was overexpressed through bioinformatics, immunohistochemistry, qRT‐PCR. In cell lines, CD47‐targeted near‐infrared photoimmunotherapy (NIR‐PIT) induced cytotoxicity light dose‐dependent manner. Laser confocal microscopy revealed intervention significantly increased phagocytic effect macrophages on cells. mice model partial tumor resection mediated by OMI, compared group A (immune therapy alone), C (NIR‐PIT treatment) showed reduced recurrence rate after NIR‐PIT intervention. However, difference did not reach statistical significance. We then evaluated maintenance mice. indicated that, untreated animals, growth slower using CD47‐Alexa Fluor 790 (CD47‐AF790), allowing more sustained control. freshly isolated whole uterus specimens from patients were co‐incubated CD47‐AF790, enhanced contrast NIR visible images tissue observed, demonstrating high sensitivity specificity (tumor‐to‐background ratio >5.05). Finally, under fluorescence microscopy, specific fluorescent signals are observed conclusion, accurate excision can be accomplished employing agents OMI technology. This method shows potential viable promising approach diagnosis EC.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 283 - 300
Published: Feb. 18, 2025
This study explores the accreditation challenges faced by MBA programs with a focus on Marketing Management in public universities across India. Despite growing demand for quality management education, many institutions struggle to meet standards due resource constraints, curriculum alignment issues, and evolving industry expectations. The research aims identify hurdles propose actionable solutions enhance process. is based descriptive analysis where data case studies from selected are examined through qualitative methods. findings reveal common challenges, including gaps faculty expertise, inadequate infrastructure, misalignment between academic offerings market needs. highlights best practices successful that have overcome these barriers, offering roadmap others follow offer valuable insights policymakers educators aiming elevate of marketing education India's sector.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 67 - 86
Published: Feb. 18, 2025
The research addresses the critical need for robust accreditation processes in medical education. problem lies ensuring that institutions not only meet but consistently uphold international standards of quality, given complexity healthcare demands and diverse challenges faced by globally. study aims to identify analyze successful strategies implemented schools, focusing on how these contribute maintaining excellence education patient care. Using a descriptive design, reviews case studies from accredited colleges worldwide, examining frameworks, methodologies, best practices have led their success. Results indicate schools employing continuous self-assessment, strong leadership commitment, collaborative are more likely maintain high foster innovation training delivery.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Abstract With the intensification of aging issues, inflammatory orthopedic diseases almost occur in majority elderly people, which is becoming increasingly severe. Photoacoustic imaging (PAI) a non‐invasive visualization technique for clear diagnosis inflammation areas through detecting acoustic signals generated by laser irradiation. The combination “light input” and “acoustic output” provides unprecedented scalability as well high penetration depth resolution. This new technology can also present more anatomical information feedback status activity diseases. Especially imaging, this effectively supplement current clinical methods diagnosis, staging, monitoring pathophysiological processes. rapid development these technologies, goals precise predictive regulation, ultimately personalized treatment strategies are realistic. Herein, article introduces various inflammations related applications. It covers types PA nanoprobes their research progress inflammation, potential applications PAI aspects. review discusses recent researches emerging translational prospects future challenges transformation.
Language: Английский
Citations
0