Association Between Serum Triglyceride Levels and the Severity of Acute Pancreatitis: A Retrospective Study

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Background Acute pancreatitis (AP) is a potentially fatal condition with poor prognosis if it escalates to its severe form. The pathophysiology of AP has been associated serum triglyceride (TG) levels. However, the relationship between levels and severity remains poorly understood. Therefore, this study aimed investigate correlation TG AP. Methods This retrospective was conducted at Benazir Bhutto Hospital (BBH) in Rawalpindi, Pakistan, from January 2023 2024, among 210 patients Data gathered on self-devised proforma medical records. Ranson criteria score utilized assess Patients were divided into two groups: non-severe basis their score. analysis done Statistical Package for Social Sciences (SPSS) version 25 (IBM Corp., Armonk, NY) through chi-squared test, independent t-test, Pearson's correlation, simple linear regression analysis. p-value less than 0.05 set as significant. Results Of patients, 135 (64.28%) had AP, while 75 (35.72%) Values variables including gender, age, white blood cell (WBC) count, aspartate transaminase (AST) levels, glucose lactate dehydrogenase (LDH) score, amylase lipase body mass index, length hospital stay significantly (p < 0.05) higher indicated that positively scores (coefficient {r} = 0.80; p 0.003). Moreover, confirmed level significant predictor severity, beta coefficient (β) 3.21 95% confidence interval (CI) 1.82-4.72 0.002). frequency clinical outcomes such pancreatic necrosis, intensive care unit (ICU) admission, mortality elevated Conclusions In current study, found be an increased suggested by adverse raised supports use reliable tool prompt identification high-risk facilitating timely interventions improved outcomes.

Language: Английский

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Association between pan-immune-inflammation value and dyslipidemia in the United States population

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

To investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia. This cross-sectional study used data obtained from National Health Nutrition Examination Survey (NHANES). The independent variable logarithmic form of PIV-log2 (PIV). definition dyslipidemia was based on Cholesterol Education Program standards. Weighted multivariate logistic regression analyses, restricted cubic spline (RCS) threshold effect analysis were explore PIV Stratified analyses to identify potential associations with other covariates. receiver operating characteristic (ROC) curve constructed compared systemic immune-inflammation index (SII). 6,821 participants included, whom 47% male 77% had After adjusting for all confounders, an significantly positive (OR (95%CI): 1.13 (1.01-1.25); P = 0.03). Compared lowest quartile (Q1) PIV, highest (Q4) a higher risk 1.37 (1.05-1.80); 0.022). RCS showed inverted J-shaped relationship (P-nonlinear 0.0415, P-overall < 0.001). revealed that inflection point 9.192. age BMI modified PIV-dyslipidemia (P interaction 0.05). ROC found SII, similar predictive (area under (AUC): 0.566 vs 0.558; 0.073). discovered dyslipidemia, especially in young overweight individuals.

Language: Английский

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Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis

The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes

Published: March 5, 2024

Elevated circulating triglyceride levels have been linked to an increased risk of diabetes, although the precise mechanisms remain unclear. This study aimed investigate whether low-density lipoprotein (LDL) cholesterol, homeostatic model assessment (HOMA) for insulin resistance, and C-reactive protein served as mediators in this association across a sample 18,435 US adults. Mediation analysis was conducted using PROCESS Version 4.3 Macro SPSS. Simple medi-ation revealed that all three potential played role mediating associa-tion. However, parallel mediation analysis, where were simultaneously included, HOMA resistance remained significant mediator (indirect effect coefficient, 0.47; 95% confidence interval [CI], 0.43—0.52; p &lt; 0.05) after adjusting tested confounding factors. Conversely, LDL cholesterol -0.13; CI, -0.31—0.05; &gt; 0.01; -0.003—0.02; ceased be mediators. accounted 49% between triglycerides diabetes. In conclusion, dominant underlying Therefore, reducing may hold promise improving sensitivity diabetic patients.

Language: Английский

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Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes

Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 733 - 733

Published: March 29, 2024

Elevated circulating triglyceride levels have been linked to an increased risk of diabetes, although the precise mechanisms remain unclear. This study aimed investigate whether low-density lipoprotein (LDL) cholesterol, homeostatic model assessment (HOMA) for insulin resistance, and C-reactive protein (CRP) served as mediators in this association across a sample 18,435 US adults. Mediation analysis was conducted using PROCESS Version 4.3 Macro SPSS. Simple mediation revealed that all three potential played role mediating association. However, parallel analysis, where were simultaneously included, HOMA resistance remained significant mediator (indirect effect coefficient, 0.47; 95% confidence interval [CI], 0.43–0.52; p < 0.05) after adjusting tested confounding factors. Conversely, LDL cholesterol −0.13; CI, −0.31–0.05; > 0.01; −0.003–0.02; ceased be mediators. accounted 49% between triglycerides diabetes. In conclusion, dominant underlying Therefore, reducing may hold promise improving sensitivity diabetic patients.

Language: Английский

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Impact of Serum Triglyceride Levels on Severity and Outcomes in Acute Biliary Pancreatitis: A Retrospective Cohort Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Background Acute biliary pancreatitis (ABP), a major inflammatory illness, is primarily caused by gallstone blockage of the common bile duct. The pathophysiology ABP has been linked to serum triglyceride (TG) levels, suggesting potential role for TG in predicting disease severity. Objective research objective was investigate association between levels and severity ABP. Methodology This retrospective cohort study sought determine relationship blood It conducted at Lady Reading Hospital Peshawar, Pakistan, from September 2023 March 2024. A total 530 patients were divided into two groups based on their levels: normal (<150 mg/dl) elevated (≥150 mg/dl). Clinical data gathered, including demographics, comorbidities, laboratory results, ratings (APACHE II Ranson's criteria), clinical outcomes. Descriptive statistics, Chi-square tests, multivariate logistic regression used statistical analysis. Results Patients with (n=130) demonstrated higher median criteria (3.24 vs. 2.53, p<0.001) APACHE scores (10.53 8.73, compared those (n=400). Elevated associated increased ABP, ORs 2.41 (95% CI: 1.23-4.74) mild severe outcomes such as ICU admission (21.54% 3.25%, p<0.001), mortality (6.15% 0.50%, pancreatic necrosis (10.77% 1.25%, significantly worse group. Conclusion are independently indicated poorer

Language: Английский

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Metabolites and Lipoproteins May Predict the Severity of Early Acute Pancreatitis in a South African Cohort

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2431 - 2431

Published: Oct. 23, 2024

Acute pancreatitis (AP) can be life-threatening with unpredictable severity. Despite advances in management, its pathogenesis remains unclear. This study investigated metabolites and lipoprotein profiles AP patients of African descent to understand the underlying pathophysiological conditions so as inform prognosis management.

Language: Английский

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A Mendelian randomization study on associations between plasma lipidome, circulating inflammatory proteins, and erectile dysfunction

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(12), P. 2724 - 2734

Published: Dec. 1, 2024

Some studies suggest a potential association between plasma lipidome and erectile dysfunction (ED), but the underlying mechanism whether circulating inflammatory proteins act as mediators remain unclear. The purpose of this study was to investigate causal relationships lipidome, proteins, ED. Plasma ED cases were identified based on summary data from several large-scale genome-wide (GWAS). with explored by bidirectional two-sample, two-sample Mendelian randomization (MR) method. inverse variance weighted (IVW) method used primary analytical MR-Egger median methods utilized supplementary techniques. Sensitivity analyses including MR-Pleiotropy RESidual Sum Outlier (PRESSO), Cochran's Q test, intercept test conducted address heterogeneity horizontal pleiotropy. Ceramide (d42:2) triacylglycerol (56:3) found be associated an increased risk ED, while phosphatidylethanolamine (O-18:1_18:2) phosphatidylinositol (18:1_18:1) linked decreased Interleukin-1α (IL-1α), IL-7, IL-17C, tumor necrosis factor (TNF) receptor superfamily member 9 (TNFRSF9) positively affected Conversely, leukemia inhibitory urokinase-type plasminogen activator (uPA) showed negative impact. Mediation analysis indicated that uPA mediated Triacylglycerol accounting for mediation proportion -14.71%. There relationship Circulating appeared mediate levels

Language: Английский

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