No reliable gray matter alterations in idiopathic dystonia

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background The structural brain abnormalities associated with idiopathic dystonia (ID) remain inadequately understood. Previous voxel-based morphometry (VBM) studies examining whole-brain gray matter (GM) volume alterations in patients ID have reported inconsistent and occasionally contradictory findings. Methods We performed a coordinate-based meta-analysis (CBMA) using the latest seed-based d mapping permutation of subject images (SDM-PSI) technique to identify consistent GM at level. Additionally, meta-regression analyses were conducted explore potential moderating effects age, gender, disease duration on volume. Results CBMA incorporated 27 VBM studies, comprising 32 datasets total 840 834 healthy controls. Our analysis did not or reliable ID. robustness these findings was confirmed through jackknife sensitivity analysis. Meta-regression revealed that significantly influenced right insula. Conclusion Based best practice guidelines for CBMA, we utilized most recent SDM-PSI algorithm perform new included larger group individuals However, contrast previous CBMAs, observe any suggest assessed by as an imaging marker may be reliable. This could attributed being functional disorder, inconsistency demographic clinical variations, differences protocols methods, small sample sizes. It is imperative control characteristics, employ standardized methodologies, enhance sizes future research.

Language: Английский

Cerebral‐Cerebellar Cortical Activity and Connectivity Underlying Sensory Trick in Cervical Dystonia

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(10), P. 2633 - 2644

Published: Aug. 16, 2024

Abstract Objective The objective of this study was to investigate the activity and connectivity cerebral cerebellar cortices underlying sensory trick (ST) effects in patients with cervical dystonia (CD), using electroencephalography (EEG). Methods We recruited 15 CD who exhibited clinically effective ST healthy controls (HCs) mimicked maneuver. EEG signals multiple‐channel electromyography (EMG) were recorded simultaneously during resting acting stages. source analysis functional performed. To account for processing, we calculated relative power changes as difference spectral density between maneuver execution. Results induced a decrease low gamma (30–50 Hz) primary cortices, which remained lower than HCs maintenance period. Compared HCs, consistently strengthened within sensorimotor network period, particularly sensory‐sensorimotor cerebellum connection. Interpretation application resulted altered cortical excitability regulated by oscillation patients, suggesting that effect cannot be solely attributed motor components. may play important roles mediating effects.

Language: Английский